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Recent advances in dna glycosylase assays

Chinese Chemical Letters 2022年第8期33卷 3603-3612页

作者： Lili Wang Huige Zhang Wei Chen Hongli Chen Jianxi Xiao Xingguo Chen State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China

Genomic deoxyribonucleic acid(dna)is selected as the ideal carrier for preserving and transmitting the genetic information over the course of ***,the genomic dna is constantly exposed to various endogenous and environmental threats,causing a diversity of damaged bases,lesions,mismatches and base-pair modifications in the genome,eventually leading to genomic instability and *** excision repair(BER)is the most important repair mechanism,repairing a variety of dna damages arising from oxidation,alkylation,methylation,deamination,and hydrolysis *** glycosylases are responsible for initiating the first step of the BER pathway through cleaving the N-glycosidic bond between the damaged base and the dna ***,abnormal dna glycosylases are associated with a variety of diseases such as cancer,cardiovascular disease,neurological disease and inflammation,suggesting the important role of dna glycosylases in cancer diagnosis and ***,it is highly desirable to monitor the activity of dna glycosylases,gaining a deep understanding of the restoration process of damaged dna and clinical ***,a series of novel dna glycosylases detection methods with excellent performance have been *** this minireview,we summarize the recent advances in dna glycosylase assays including amplification-free assay and amplification-assisted ***,a brief introduction of amplification-free assay for dna glycosylase is ***,amplification-assisted assays for dna glycosylases are discussed in ***,the conclusion and prospects of the directions of dna glycosylase assays are provided.

关键词： dna glycosylases Base excision repair Polymerase chain reaction Isothermal signal amplification Nanomaterial-based biosensors

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