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Modeling dna ＆ rna mutation using mset and topology

International Journal of Biomathematics 2018年第4期11卷 257-270页

作者： M. M. El-Sharkasy M. S. Badr Department of Mathematics Faculty of Science Tanta University Tanta Egypt Department of Mathematics Faculty of Science Assuit University New Valley Egypt

Mathematical equations are now found not only in the books, but also they help in finding solutions for the biological problems by explaining the technicality of the current biological models and providing predictions that can be validated and complemented to experimental and clinical studies. In this research paper, we use the mset theory to study dna ＆： rna mutations to discover the mutation occurrence. Also, we use the link between the concept of the meet and topology to determine the compatibility or similarity between ＂types＂, which may be the strings of bits, vectors, dna or rna sequences, etc.

关键词： Mutation dna and rna similarity mset topology.

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Separation axioms under crossover operator and its generalized

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International Journal of Biomathematics 2016年第4期9卷 169-191页

作者： M. M. El-Sharkasy M. Shokry Department of Mathematics Faculty of Science Tanta University Tanta Egypt Department of Physics and Engineering MathematicsFaculty of Engineering Tanta University Tanta Egypt

The purpose of this work is to construct a new crossover operator using the properties of dna and rna by using topological concepts in constructing flexible mathematical models in the field of biomathematics. Also, we investigate and study topological prop- erties of the constructed operators and the associated topological spaces of dna and rna. Finally we use the process of exchange for sequence of genotypes structures to construct new types of topological concepts to investigate and discuss several examples and some of their properties.

关键词： dna and rna genotypes topology (To, T1, T2)-crossover space.

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Chemical and structural biology of nucleic acids and protein-nucleic acid complexes for novel drug discovery

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Science China Chemistry 2011年第1期54卷 3-23页

作者： GAN JianHua SHENG Jia HUANG Zhen Department of Chemistry Georgia State UniversityAtlantaGA 30303USA

Since nucleic acids(dna and rna) play very important roles in cells,they are molecular targets of many clinically used drugs,such as anticancer drugs and *** of clinical demands for treating various deadly cancers and drug-resistant strains of pathogens,there are urgent needs to develop novel therapeutic *** nucleic acids hasn’t been the mainstream of drug discovery in the past,and the lack of 3D structural information for designing and developing drug specificity is one of the main ***,many important structures of nucleic acids and their protein complexes have been determined over the past decade,which provide novel platforms for future drug design and *** this review,we describe some useful nucleic acid structures,particularly their interactions with the ligands and therapeutic candidates or even *** summarize important information for designing novel potent drugs and for targeting nucleic acids and protein-nucleic acid complexes to treat cancers and overcome the drug-resistant problems.

关键词： nucleic acid targets dna and rna protein-nucleic acid complexes dna duplex and junction G-quadruplex ribozyme riboswitch ribosome topoisomerase inhibitors antibiotics structure-based drug design therapeutic agents

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