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LIPASE－CATAL　YZED　DOUBLE　KINETIC　RESOLUTION　OF　dl－2，4－DIMETHYL－1，5－PENTANEDIOL：A　USEFUL　SYNTHON　IN　NATURAL　PRODUCT　SYNTHESIS

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Chinese Chemical Letters 1996年第2期7卷 129-130页

作者： Jian Wen FANG Zu Yi LI(Shanghai Institute of Organic of Organic Chemistry,Academ Sinica 354 Fenglin Lu, Shanghai 200032) Shanghai of Organic Chemistry Academia Sinica 354 Fenglin Lu Shanghai 200052 China

An importment chiral synthon (-)-2,4-dimethyl-1,5-pentanediol and its diester and monoester were obtained by lipase-catalyzed double kinetic resolution.

关键词： dl OF RESOLUTION KINETIC DOUBLE CATAL DIMETHYL

Multi Criteria Decision Making System for Parking System

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Computer Systems Science & Engineering 2021年第1期36卷 101-116页

作者： Manjur Kolhar Abdalla Alameen College of Arts and Science Prince Sattam bin Abdulaziz University11990Saudi Arabia

System supported smart parking can reduce traffic by making it stress free to locate empty parking spaces,hence lowering the risk of unfocussed driving.In this study,we propose a smart parking system using deep learning and an application-based approach.This system has two modules,one module detects and recognizes a license plate(LP),and the other selects a parking space;both modules use deep learning techniques.We used two modules that work independently to detect and recognize an LP by using an image of the vehicle.To detect parking space,only deep learning techniques were used.The two modules were compared with other state-of-the-art solutions.We utilized the You Only Look Once(YOLO)architecture to detect and recognize an LP because its performance in the context of Saudi Arabian LP numbers was superior to that of other solutions.Compared with existing state-of-the-art solutions,the performance of the proposed solution was more effective.The solution can be further improved for use in the city and large organizations that have priority parking spaces.A dataset of LP-annotated images of vehicles was used.The results of this study have considerable implications for smart parking,particularly in universities;in addition,they can be utilized for smart cities.

关键词： Parking LBP dl CNN license plate

Preparation and Properties of Self-reinforced L-and D,L-lactide Copolymer Rods

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Chinese Chemical Letters 2000年第11期11卷 1023-1026页

作者： Hu Y.S. Zhang Z.P. Song D. Wang Y.M. Bai D.R. Institute of Polymer Chemistry State Key Lab. Funct. Polymeric M. Nankai University Tianjin 300071 China

Since highly crystalline poly (L-lactide) (PLLA) degrades rather slowly in a biological environment and the crystalline domains remaining after partial degradation of the implant material give rise to an inflammatory response of the surrounding tissue, L- and D,L-lactide copolymer [P(L-dl)LA] having a low crystallinity is preferred in surgical applications. The thermal transitions and the mechanical properties of P(L-dl)LA rods were discussed in this paper. It was found that the self-reinforced P(L-dl)LA [SR-P(L-dl)LA] was strong enough in terms of mechanical properties compared with the self-reinforced PLLA [SR-PLLA].

关键词： dl Preparation and Properties of Self-reinforced L-and D,L-lactide Copolymer Rods PLLA

Artificial Intelligence Driven Nuclear Power Reactors(A Technical Memorandum)

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Journal of Energy and Power Engineering 2022年第2期16卷 71-80页

作者： Seyed Kamal Mousavi Balgehshiri Ali Zamani Paydar Bahman Zohuri Physics and Energy Engineering Department Amirkabir University of TechnologyTehranIran Galaxy Advanced Engineering AlbuquerqueNew Mexico 87111USA Golden Gate University San FranciscoCalifornia 94105USA

The 21st Century era and new modern technologies surrounding us day-in and day-out have opened a new door to“Pandora Box”,that we do know it as AI(artificial intelligence)and its two essential integrated components namely ML(machine learning)and dl(deep learning).However,the strive and progress in AI,ML,and dl pretty much has taken over any industry that we can think of,when it comes to dealing with cloud of structured data in form of BD(big data).A NPP(nuclear power plant)has multiple complicated dynamic system-of-components that have nonlinear behaviors.For controlling the plant operation under both normal and abnormal conditions,the different systems in NPPs(e.g.,the reactor core components,primary and secondary coolant systems)are usually monitored continuously,which leads to very huge amounts of data.Of course Nuclear Power Industry in form of GEN-IV(Generation IV)has not been left behind in this 21st century era by moving out of GEN-III(Generation III)to more modulars form of GEN-IV,known as SMRs(small modular reactors),with a lot of electronic gadgets and electronics that read data and information from it to support safety of these reactor,while in operation with a built in PRA(probabilistic risk assessment),which requires augmentation of AI in them to enhance performance of human operators that are engaged with day-to-day smooth operation of these reactors to make them safe and safer as well as resilience against any natural or man-made disasters by obtaining information through ML from dl that is collecting massive stream of data coming via omni-direction.Integration of AI with HI(human intelligence)is not separable,when it comes to operation of these smart SMRs with state of the art and smart control rooms with human in them as actors.This TM(technical memorandum)is describing the necessity of AI playing with nuclear reactor power plant of GEN-IV being in operation within near term sooner than later,when specially we are facing today’s cyber-attacks with their smart malware agents at work.

关键词： AI ML dl BD nuclear reactor and nuclear energy electrical grid PRA reactor safety DA(data analytics)and PA(predictive analytics).

RESOLUTION　OF　dl－α－AMINO　ACIDS　ON　A　L－HYDROXY　PROLINE　CHIRAL　PHASE　BY　LIGAND－EXCHANGE　CHROMATOGRAPHY

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Chinese Chemical Letters 1995年第5期6卷 383-384页

作者： Tao CHEN Tian Bao HUANG(Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041) Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China

A HPLC bonded phase with L- hydroxy proline was prepared by coupling L-hydroxy proline as a chiral selector to silical gel via 3- glycidyloxypropyltrimethoxysilane. The chiral separations of 12 dl - amino acids on the chiral phase were performed and the effects of the chromatographic conditions,the pH of the mobile phase and the column temperature, on the resolution of dl-α-amino acids were studied.

关键词： dl OF RESOLUTION ACIDS AMINO

ON THE UNIQUE SOLVABILITY OF THE NONLINEAR SYSTEMS IN MDBM

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Journal of Computational Mathematics 1994年第1期12卷 55-60页

作者： Kuang Jiao-xun Lu Lian-hua (Department of Mathematics, Shanghai Normal University, Shanghai, China) 上海师范大学数学系上海

To obtain the approximate solution of the nonlinear ordinary differential equations requires the solution to systems of nonlinear equations. The authors study the conditions for the existence and uniqueness of the sol... 详细信息

关键词： dl ON THE UNIQUE SOLVABILITY OF THE NONLINEAR SYSTEMS IN MDBM

番薯胡萝卜苷亚油酸酯抑制乳腺癌转移机制研究

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番薯胡萝卜苷亚油酸酯抑制乳腺癌转移机制研究

作者：黄璐西南大学

学位级别：硕士

近10年来,癌症一直是全球主要的公共卫生问题,且已经成为我国第三大、美国第二大死亡原因。近年来,我国乳腺癌的发病率呈现上升趋势,在55岁左右达到发病高峰期,其中城市地区的发病率和死亡率均高于农村地区,其中后期乳腺癌发生转移才是... 详细信息

近10年来,癌症一直是全球主要的公共卫生问题,且已经成为我国第三大、美国第二大死亡原因。近年来,我国乳腺癌的发病率呈现上升趋势,在55岁左右达到发病高峰期,其中城市地区的发病率和死亡率均高于农村地区,其中后期乳腺癌发生转移才是导致乳腺癌患者死亡的主要原因。但是到目前止,我们对转移性乳腺癌的基础理论研究尚不充分,临床上也缺乏有效的检测靶标和治疗药物。转移性乳腺癌是一个世界性难题。目前针对乳腺癌转移的治疗有放疗化疗,但易出现耐药性和毒副作用,因此开发安全有效且毒副作用小的乳腺癌辅助药物很有必要。番薯作为世界上第七大经济作物,其块根、茎和叶都可食用,并且含有多种对人体健康有益的成分,如糖蛋白、胡萝卜素等。课题组前期研究发现番薯提取物中的胡萝卜苷亚油酸酯(Daucosterol Linoleate,dl)对乳腺癌肺转移有显著抑制作用。本文旨在探究dl对乳腺癌转移的抑制作用机制。本研究主要从以下几方面展开实验:(1)研究dl体外对乳腺癌细胞的转移的抑制作用。运用MTT实验分析dl对乳腺癌细胞4T1、MCF-7、MDA-MB-231细胞活力的影响,结果发现,在三种乳腺癌细胞中,MCF-7细胞对dl处理较敏感,在三个细胞中,dl抑制4T1细胞活力较弱(IC50:96.45μM),其次是MDA-MB-231(IC50:93.00μM),MCF-7(IC50:79.84μM)。运用细胞划痕实验和Transwell迁移实验检测dl对三个细胞系迁移能力的抑制作用,分析发现dl对4T1抑制迁移能力最强,其次是MCF-7和MDA-MB-231。(2)研究dl体内抗乳腺癌转移作用。选用高转移性MDA-MB-231乳腺癌细胞建立裸鼠尾静脉注射肺转移模型,通过灌胃dl的方式观察体内dl抗MDA-MB-231乳腺癌转移的效果。结果显示dl灌胃剂量87.8 mg/kg时对裸鼠的体重无影响。肺组织切片H&E染色结果显示,dl对MDA-MB-231乳腺癌裸鼠尾静脉注射肺转移模型的抑制率可达到63.16%。(3)探索dl抑制乳腺癌转移的潜在靶标。利用前期课题组荷瘤裸鼠肺转移蛋白质组学进行GSEA基因集富集分析,结果显示上皮间质-转化和雌激素早期应答与dl组显著相关。经筛选找出VAMP3、TAP2、CHK1、SCD1和LOXL2,这些dl潜在作用靶标,经q PCR验证、分子对接模拟dl与之的结合模型,最终筛选到SCD1为潜在靶标。(4)研究dl与SCD1在乳腺癌转移抑制过程中的关系。运用q PCR和WB检测4T1、MCF-7、MDA-MB-231三个细胞系中SD1的m RNA和蛋白表达水平,选择表达水平最高的MDA-MB-231细胞开展后续实验。用MTT法测定SCD1蛋白抑制剂PluriSIn1处理MDA-MB-231细胞24h的IC50。通过细胞划痕实验和Transwell迁移实验检测过表达SCD1后给予dl对MDA-MB-231迁移能力的影响,结果显示,过表达SCD1后细胞迁移能力显著提高,dl处理可以有效降低细胞的迁移率,使迁移率仅达到普通MDA-MB-231细胞的49.4%-67.5%,表明dl可以逆转SCD1过表达导致的MDA-MB-231的迁移率能力增强,SCD1蛋白抑制剂PluriSIn1对MDA-MB-231的迁移抑制作用显著。(5)dl调节EMT途径标志蛋白的表达。用1/2IC50和IC50浓度的dl和PluriSIn1处理MDA-MB-231,WB检测EMT途径标志蛋白N-Cadherin、MMP2、Vimentin、Snail和ER的蛋白表达,均出现剂量依赖性下降,SCD1同样表达下降。WB检测过表达SCD1的MDA-MB-231中的EMT途径标志蛋白的表达,发现过表达SCD1后这些蛋白均出现表达上调,但给予dl或PluriSIn1处理后,EMT途径标志蛋白的表达水平下降至与Victor相近。(6)验证dl在体内通过降低SCD1的表达来抑制乳腺癌的转移。通过慢病毒包装系统构建稳定过表达SCD1的oe-SCD-MDA-MB-231细胞系,建立乳腺癌裸鼠尾静脉注射肺转移模型,接种oe-SCD-MDA-MB-231一周后开始灌胃dl组,PluriSIn1作为靶向SCD1的阳性药通过腹腔注射给药,3周后取裸鼠肺组织染色后发现,与oe-SCD组比较,dl和PluriSIn1可显著抑制oe-SCD-MDA-MB-231在裸鼠体内的肺转移,减少肺转移结节数量,抑制转移灶大小。综上所述,本研究证实dl具有显著的抗乳腺癌转移的作用,dl通过降低SCD1的表达参与抑制乳腺癌细胞迁移。通过oe-SCD-MDA-MB-231的系列实验证明,SCD1的表达与EMT途径标志蛋白的表达呈正相关性,dl可通过降低SCD1的表达来抑制EMT和乳腺癌转移的发生。

关键词：乳腺癌转移 dl SCD1

单相合金凝固过程时间相关的界面稳定性(I)理论分析

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物理学报 2004年第11期53卷 3971-3977页

作者：林鑫李涛王琳琳苏云鹏黄卫东西北工业大学凝固技术国家重点实验室西安710072

对定向凝固界面前沿非稳态溶质扩散场进行了系统的对比分析 ,发现无论在纯扩散还是存在对流的情况下 ,界面前沿的溶质扩散场通常满足指数分布的形式 ,可以采用一个统一的公式来描述界面前沿的瞬态溶质扩散场 .进而在此基础上 ,对定向凝... 详细信息

对定向凝固界面前沿非稳态溶质扩散场进行了系统的对比分析 ,发现无论在纯扩散还是存在对流的情况下 ,界面前沿的溶质扩散场通常满足指数分布的形式 ,可以采用一个统一的公式来描述界面前沿的瞬态溶质扩散场 .进而在此基础上 ,对定向凝固界面形态稳定性进行了统一的时间相关的非稳态分析 ,发现界面临界稳定性条件的数学描述形式与Mullins和Sekerka理论给出的稳态解完全一致 ,只是用时间相关的浓度梯度GtC 、界面速度Vi、溶质扩散长度l代替了稳态生长中所得到的GC,V ,dl

关键词：时间相关稳定性条件溶质扩散前沿稳态解指数分布 GC dl 对比分析

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基于描述逻辑的能力需求模型验证方法

系统工程与电子技术 2010年第3期32卷 533-539页

作者：董庆超王智学陈剑张义解放军理工大学指挥自动化学院江苏南京210007

针对C4ISR系统能力需求模型中存在的一致性和合理性问题,提出了一种能力需求模型的验证方法。先采用基于描述逻辑的本体描述语言OWLdl精确描述能力需求分析中的元概念模型和应用概念模型,然后在元概念模型和应用概念模型之上附加一定的... 详细信息

针对C4ISR系统能力需求模型中存在的一致性和合理性问题,提出了一种能力需求模型的验证方法。先采用基于描述逻辑的本体描述语言OWLdl精确描述能力需求分析中的元概念模型和应用概念模型,然后在元概念模型和应用概念模型之上附加一定的模型验证推理规则,并通过符号推理系统验证了能力概念的完整性以及目标的一致性。

关键词：描述逻辑 OWL dl 元概念模型应用概念模型