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PFNA微创治疗高龄股骨粗隆间骨折患者的临床疗效观察

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中文科技期刊数据库（全文版）医药卫生 2024年第1期 58-61页

作者：高志鹏欧舒婷南方医科大学南方医院白云分院广东广州511000

探讨高龄股骨粗隆间骨折患者接收PFNA术微创的治疗效果。方法选取南方医学白云分院骨科近4年(2019年8月-2022年8月)收治的 84 例股骨粗隆间骨折高龄患者。采取随机数字表法对其进行分组,一组为对照组(42例,dhs术治疗),另一组为观察组(4... 详细信息

探讨高龄股骨粗隆间骨折患者接收PFNA术微创的治疗效果。方法选取南方医学白云分院骨科近4年(2019年8月-2022年8月)收治的 84 例股骨粗隆间骨折高龄患者。采取随机数字表法对其进行分组,一组为对照组(42例,dhs术治疗),另一组为观察组(42例,PFNA术治疗)。对比2组患者基线资料无显著性差异后,1组患者施行动力髋加压螺钉(dhs)术式,是为对照组。另一组患者施行近端防旋髓内钉(PFNA)术式,是为观察组。术后两组患者皆按常规护理,分别记录和收集患者手术史、护理、恢复状况及生活质量等有关数据。结果在手术史和护理方面,相比对照组患者,观察组手术时长、出血量、术后引流量、负重时间、住院时间和并发症发生率显著降低,差异均有统计学意义(Pdhs,高龄患者股骨粗隆间骨折采用PFNA 治疗,临床指标、恢复状况及生活质量得到改善,实际疗效较为显著,可在临床上予以推广使用。。

关键词：高龄股骨粗隆间骨折 PFNA dhs

Dapsone hypersensitivity syndrome

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Chinese Medical Journal 2023年第13期136卷 1560-1562页

作者： Qing Zhao Lele Sun Yonghu Sun Dean Naisbitt Hong Liu Furen Zhang Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Department of Molecular and Clinical Pharmacology MRC Centre for Drug Safety ScienceUniversity of LiverpoolLiverpoolUK

Dapsone hypersensitivity syndrome(dhs)was first reported by Lowe and Smith[1]in 1949 in Nigeria and was termed“dapsone syndrome”by Allday and Barnes[2]in 1951.dhs is a drug-induced hypersensitivity syndrome(DIHS)caused by dapsone 404’-diaminodiphenylsulfone(DDS).dhs is characterized by fever,rash,lymphadenopathy,and hepatitis,which usually develop after patients receive DDS for 5 to 6 weeks.Epidemiological studies have estimated dhs prevalence and fatality rates of 1.4%and 9.9%,respectively.[3]Until recently,the“wait and see”approach was used for patients with suspected dhs.Herein,we review recent developments in dhs research,focusing on its etiology,pathogenesis,diagnosis,and prevention,to make DDS a safer medication for most of the population through the prospective exclusion of susceptible patients before DDS administration.

关键词： dhs prevention diagnosis

维普期刊数据库

美国土安全部发布“创新、研究与开发战略计划”,指导未来七年投资重点

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金属功能材料 2024年第3期31卷 85-85页

据美国土安全部(dhs)5月28日消息,dhs于5月13日发布有史以来第一个全部门“创新、研究与开发(IRD)战略计划”,阐明dhs任务需要的八个战略重点研究领域 (SPRA) 和能力,未来七年将进行重点投资。2024-2030财年的战略重点研究领域包括:先... 详细信息

据美国土安全部(dhs)5月28日消息,dhs于5月13日发布有史以来第一个全部门“创新、研究与开发(IRD)战略计划”,阐明dhs任务需要的八个战略重点研究领域 (SPRA) 和能力,未来七年将进行重点投资。2024-2030财年的战略重点研究领域包括:先进传感;人工智能和自主系统;生物技术;气候变化;通信和网络;网络安全;数据集成、分析、建模和模拟;数字身份和信任。

关键词：研究与开发 dhs 人工智能重点研究领域数据集成国土安全部网络安全数字身份

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Spatio-temporal variation in childhood growth in Nigeria:a comparison of aggregation and interpolation

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International Journal of Digital Earth 2017年第11期10卷 1166-1176页

作者： Elise Hellwig Robert J.Hijmans Environmental Science and Policy University of CaliforniaDavisDavisCAUSA

The mean height-for-age Z-score(HAZ)of children under five is an important indicator of the health status of a population.HAZ values are frequently aggregated and reported at the national level,potentially obscuring important within-country variation.We evaluated aggregation and interpolation methods to provide sub-national estimates over space and time,using survey data from Nigeria in 1990,2003,2008,and 2013.We aggregated HAZ values by region and by state,and interpolated the values spatially and spatio-temporally using thin plate splines.The results were evaluated with cross-validation using the root mean squared error(RMSE)as a measure of goodness of fit.Mean HAZ values increased from 1990 to 2013,but values rose more sharply in southern Nigeria than in the North.All methods performed better than assuming a constant national average.The state-level aggregation,and the spatial and spatio-temporal interpolations had similar RMSE values,but the interpolation methods showed more detailed spatial variation.Spatio-temporal interpolation produced good results in all conditions,including in years with sparse sampling and when extrapolating to years for which there were no observations.

关键词： Height-for-age health surveys dhs prediction stunting

The start of a human life program

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Journal of Genetics and Genomics 2018年第4期45卷 183-184页

作者： Falong Lu State Key Laboratory of Molecular Developmental Biology Institute of Cenetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China University of the Chinese Academy of Sciences Beijing 100039 China

The genetic information of a human being is encoded in the genomic DNA of about 3 billion base pairs.Every new individual starts from a one-cell zygote,or called fertilized egg,carrying genetic and epigenetic informat... 详细信息

关键词： ZGA The start of a human life program dhs DNase

维普期刊数据库

Analysing the Factors Affecting Prenatal Visits in Guinea: A Secondary Study of the 2018 Demographic and Health Survey (dhs)

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Open Journal of Obstetrics and Gynecology 2023年第8期13卷 1417-1431页

作者： Abdourahamane Diallo Almamy Amara Toure Aboubacar Sidiki Magassouba Diao Cisse Younoussa Sylla Ibrahima Barry Department of Gynaecology-Obstetrics Ignace Deen National Hospital Conakry Guinea Faculty of Health Sciences and Technologies Gamal Abdel Nasser University of Conakry Conakry Guinea National Center for Training and Research in Rural Health of Mafèrinyah Forécariah Guinea

Background: Despite persistent efforts to improve maternal health through various interventions, Guinea faces challenges in achieving adequate antenatal care coverage (ANC). This study aims to identify the key factors influencing prenatal consultation in Guinea. Methods: A secondary analysis was conducted on Guinea’s 2018 Demographic and Health Survey (dhs) data. The study sample comprised women aged 15 - 49 who participated in the survey. Logistic regression was employed to identify the determinants of ANC utilisation. Results: Most women in the sample (59.1%) were aged between 18 and 30, resided in rural areas (69.8%), had no formal education (71.0%), had low incomes (43.4%), were married (91.4%), relied on the radio for information (63.4%), and were employed at the time of the survey (68.0%). The study identified several factors acting as barriers to meeting the recommended four ANC visits, including low education levels, with odds ratios (OR) of 0.43 (p = 0.011) for those with no schooling and 0.48 (p = 0.046) for those with primary-level education. Lack of radio access also negatively influenced ANC utilisation with an OR of 0.72 (p = 0.012). Additionally, delayed timing of the first ANC visit in the second trimester had an OR of 0.36 (p 0.001), while in the third trimester, the OR was 0.04 (p 0.004). On the other hand, factors that facilitated achieving the recommended four ANC visits included having an average wealth quintile with an OR of 1.63 (p = 0.002) and being wealthy with an OR of 2.30 (p 0.001). Conclusion: This study underscores the negative association between low education level and poverty with ANC utilisation among pregnant women in Guinea. These findings emphasise the need for targeted interventions to address the barriers faced by vulnerable populations and improve maternal healthcare access and utilisation in the country.

关键词： Determinants ANC dhs Guinea

Radiation Exposure during Dynamic Hip Screw Fixation: A Comparative Study

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Open Journal of Orthopedics 2023年第3期13卷 78-83页

作者： Islam Sarhan Ramy Shehata Neil Ashwood Faculty of Medicine Alexandria University Alexandria Egypt Cambridge University Hospitals NHS Trust Cambridge UK Derby and Burton Hospitals NHS Foundation Trust Derby UK

Background: The safe amount of radiation permissible during fixation of neck of femur fractures has long been studied. Factors including surgeons’ experience have been highlighted. We aimed in this study to compare different factors for quality and safety improvement. Methods: It was a retrospective study, including all patients who had undergone a standard dhs fixation between January 2018 and June 2019 for inter-trochanteric neck of femur fractures. Two groups were stratified;(Group A) had the procedure performed by a specialist non-consultant surgeon (NCG) and (Group B) by an established consultant (CG). The Dose Area Product (DAP) and the duration of radiation exposure were recorded. Results: Over a period of 18 months, 91 cases were included with a mean age of 82 years old. The mean weight was 62 kg. 42 patients had complex fractures, and 49 patients had simple fractures. 12% of patients were ASA II, 70% of cases were ASA III and 18% of the patients were ASA IV. The mean DAP for group A was 345.131 CGYCM2 (SD 273.65) and for group B 234.63 CGYCM2 (SD 165.30). The time of exposure was 8.6 sec and 13.16 sec in groups B and A respectively. Conclusion: The data collected from this study were comparable to others. The amount of radiation exposure was of difference related to the decision-making intra-operatively. Other factors were not statistically significant.

关键词： dhs Radiation Exposure Comparative Study Neck of Femur Fracture

Religion and “Zero-Dose” Vaccination Status in Children Aged 12 to 23 Months in Benin and Togo: “Evidence of Demographic and Health Survey and Multiple Indicator Cluster Surveys”

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Open Journal of Epidemiology 2023年第4期13卷 306-327页

作者： Nyulelen Toyi Mangbassim Alphonse Kpozehouen Jacques Zinsou Saizonou Nicolas Gaffan Aissata Ba Sidibe Marie Therese Guigui Yaovi Temfan Toke Dadja Essoya Landoh Assima-Essodom Kalao Department of Epidemiology and Biostatistics Regional Institute of Public Health of Ouidah University of Abomey-Calavi Ouidah Benin Health Policy and Systems Department Regional Institute of Public Health of Ouidah University of Abomey-Calavi Ouidah Benin UNICEF Country Office of Togo Lome Togo World Health Organization Country Office of Togo Lome Togo Ministry of Health Public Hygiene and Universal Access to Care Lome Togo

Introduction: The relationship between religion and health has been a topic of interest in the past, and in recent years it has become increasingly visible in the social, behavioural, and health sciences. This work aims to study the influence of religion on the “zero-dose” vaccination status of children aged 12 - 23 months in Benin and Togo. Methods: This was a cross-sectional study which consisted in carrying out secondary analyzes using the databases of the most recent editions of the Demographic and Health Surveys in Benin and the Multiple Indicator Cluster Surveys (MICS) in Togo. We extracted data concerning the vaccination status (“1 = zero-dose”, “0 = vaccinated”) of the children, the religious affiliation of the head of the household or the mother and other variables related to the child, the mother, the household and the environment. By means of a logistic regression, the adjusted effect of the religious affiliation of the head of the household or of the mother on the vaccination status at “zero-dose” was determined. Results: A total of 2430 and 933 children were respectively included in the study on behalf of Benin and Togo. The prevalence of “zero-dose” vaccination status in children aged 12 - 23 months was 33.91% (95% CI = 31.67 - 36.23) in Benin and this prevalence was 26.88% (95% CI = 23.50 - 30.55) in Togo. In Benin, there is no evidence in favour of the influence of the religious affiliation of the mother on the “zero-dose” vaccination status of children. In Togo, children living in households whose head was Muslim (ORa = 3.44;95% CI = 1.29 - 9.13) were more likely to be “zero-dose” than those coming from households run by individuals with no religious beliefs. Conclusion: Further research is needed to understand the basis for the excess risk of “zero-dose” vaccination status in children that appears to be associated with the Muslim religion.

关键词： Vaccination “Zero-Dose” Children Religion Evidence dhs MICS Benin Togo

基于干旱敏感基因dhs筛选水稻抗干旱制剂先导化合物

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分子植物育种 2023年

作者：王超杨云峰刘红光刘婷婷谢凯丽谭德云淄博市农业科学研究院

水稻是世界一半以上人口的主要粮食作物，其生产受到干旱胁迫的严重威胁。水稻干旱敏感基因(drought hypersensitive， dhs)编码的蛋白是重要的蜡质合成负调控因子。本研究旨在通过虚拟筛选寻找dhs蛋白的先导化合物，抑制dhs活性，增加... 详细信息

水稻是世界一半以上人口的主要粮食作物，其生产受到干旱胁迫的严重威胁。水稻干旱敏感基因(drought hypersensitive， dhs)编码的蛋白是重要的蜡质合成负调控因子。本研究旨在通过虚拟筛选寻找dhs蛋白的先导化合物，抑制dhs活性，增加水稻表皮蜡质合成，增强水稻抗旱能力。通过SWISS-MODEL进行同源模建，得到了水稻干旱敏感基因dhs蛋白的空间三维结构模型，并确定水稻dhs蛋白活性位点Site1坐标为74.9、-9.4、58.4，6.6 ?。结合类药性五原则，对12万个小分子化合物的数据库进行虚拟筛选，得到的10个最佳对接打分且嵌于水稻dhs蛋白活性中心的先导化合物，通过一致性评分，确定最高得分的化合物是ZINC000029248721，其分子中腺嘌呤结构与受体dhs蛋白活性中心形成多种稳定的相互作用。同时发现，水稻干旱敏感基因dhs 6个关键氨基酸位点Lys61、Leu64、Pro65、Arg107、Leu108、Cys111在玉米、小麦、拟南芥、甜菜、大豆、蓖麻等植物中高度保守。为筛选得到的先导化合物与7个物种dhs蛋白相互作用提供参考的同时，也为研究水稻、玉米、小麦等粮食作物的抗旱制剂的研发提供基础。

关键词：干旱 dhs 虚拟筛选先导化合物