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Reverse Genetics for Peste des Petits Ruminants Virus: Current Status and Lessons to Learn from Other Non-segmented Negative-Sense RNA Viruses

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Virologica Sinica 2018年第6期33卷 472-483页

作者： Alfred Niyokwishimira Yongxi Dou Bang Qian Prajapati Meera Zhidong Zhang State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences CAAS-ILRI Joint Laboratory for Ruminant Disease Control Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences

Peste des petits ruminants(PPR) is a highly contagious transboundary animal disease with a severe socio-economic impact on the livestock industry, particularly in poor countries where it is endemic. Full understanding of PPR virus(PPRV)pathobiology and molecular biology is critical for effective control and eradication of the disease. To achieve these goals,establishment of stable reverse genetics systems for PPRV would play a key role. Unfortunately, this powerful technology remains less accessible and poorly documented for PPRV. In this review, we discussed the current status of PPRV reverse genetics as well as the recent innovations and advances in the reverse genetics of other non-segmented negative-sense RNA viruses that could be applicable to PPRV. These strategies may contribute to the improvement of existing techniques and/or the development of new reverse genetics systems for PPRV.

关键词： Peste des petits ruminants(PPR) PPRV Reverse genetics Non-segmented negative-sense RNA virus

Quantitative proteomic determination of diethylstilbestrol action on prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 413-420页

作者： Pierre Bigot Kevin Mouzat Muriel Bahut Nora Benhabiles Geraldine Cancel Tassin Abdel-Rahmene Azzouzi Olivier Cussenot Department of Urology Angers University Hospital Angers 49933 France CeRePP Tenon Hospital Paris 75970 France Department of Biochemistry N'imes University Hospital NTmes 30029 France Plate-Forme Technologique de Biotechnologie Moleculaire Angers University Angers 49933 France 5CEA DSV IRCM SREIT Laboratoire de Cancerologie Experimentale Fontenay-aux-Roses 92265 France

Diethylstilbestrol （des） has a direct cellular mechanism inhibition on prostate cancer. Its action is independent from the oestrogen receptors and is preserved after a first-line hormonal therapy. We aimed to identify proteins involved in the direct cellular inhibition effects of des on prostate cancer. We used a clonogenic assay to establish the median lethal concentration of des on 22RV1 cells. 22RV1 cells were exposed to standard and des-enriched medium. After extraction, protein expression levels were obtained by two-dimensional differential in-gel electrophoresis （2D-DIGE） and isotope labelling tags for relative and absolute quantification （iTRAQ）. Proteins of interest were analysed by quantitative RT-PCR and western blotting. The differentially regulated proteins （P〈0.01） were interrogated against a global molecular network based on the ingenuity knowledge base. The 2D-DIGE analyses revealed des-induced expression changes for 14 proteins （〉 1.3 fold; P〈0.05）. The iTRAQ analyses allowed the identification of 895 proteins. Among these proteins, 65 had a modified expression due to des exposure （i.e., 23 overexpressed and 42 underexpressed）. Most of these proteins were implicated in apoptosis and redox processes and had a predicted mitochondrial expression. Additionally, ingenuity pathway analysis placed the OAT and HSBP1 genes at the centre of a highly significant network. RT-PCR confirmed the overexpression of OAT （P=0.006） and HSPB1 （P=0.046）.

关键词： cultured cells des diethylstilbestrol ingenuity pathway analysis isotope labelling mass spectrometry prostate cancer proteomics

Treatment of coronary in-stent restenosis： a systematic review

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Journal of Geriatric Cardiology 2018年第2期15卷 173-184页

作者： Leos Pleva Pavel Kukla Ota Hlinomaz Department of Cardiovascular Diseases University Hospital Ostrava Czech Republic Department of Cardioangiology St. Anne's University Hospital and Faculty of Medicine Masaryk University Brno CZ Czech Republic International Clinical Research Center St. Anne's University Hospital Brno CZ Czech Republic

冠的 stent 培植显著地改进了经皮的冠的干预并且启用了平凡汽球 angioplasty 的早复杂并发症的管理。然而，新复杂并发症伴随了这些改进：从 neointimal 增生产生的 in-stent 狭窄(ISR ) 。在冠的 angioplasty 以后的 ISR 当前是这个... 详细信息

冠的 stent 培植显著地改进了经皮的冠的干预并且启用了平凡汽球 angioplasty 的早复杂并发症的管理。然而，新复杂并发症伴随了这些改进：从 neointimal 增生产生的 in-stent 狭窄(ISR ) 。在冠的 angioplasty 以后的 ISR 当前是这个方法的主要限制之一，导致 exertional 心绞痛或急性冠的症候群的复发。在赤裸金属的 stent (BMS ) 以后的 ISR 的临床的发生培植是近似 20%-35% 。drug-eluting stents (des ) 的使用在 ISR 的出现导致了进一步的减少到 5%-10% 。源于控制临床的研究的证据建议 des 和 drug-eluting 汽球导管(初上舞台的人) 提供临床的最好， angiographic 导致 ISR 的处理。我们为 BMS-ISR 和 des-ISR 拿了 pathophysiology，诊断和处理选择的系统的评论。我们讨论最近的 randomised 研究，比较为新 biovascular scafolds 和 scafold 狭窄的话题的 BMS 或 des-ISR 处理，以及使用使用的不同 des 或初上舞台的人。

关键词：狭窄评论系统治疗 ISR 使用使用并发症 des

New predictors of in-stent restenosis in patients with diabetes mellitus undergoing percutaneous coronary intervention with drug-eluting stent

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Journal of Geriatric Cardiology 2018年第2期15卷 137-145页

作者： Jian-Long WANG Zheng QIN Zhi-Jian WANG Dong-Mei SHI Yu-Yang LIU Ying-Xin ZHAO Li-Xia YANG Wan-Jun CHENG Yu-Jie ZHOU Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China

BackgroundPercutaneous 冠的干预(一种总线标准) 为冠的动脉疾病(CAD ) 成为了主要治疗学的过程，但是 in-stent 狭窄(ISR ) 的高率在临床的实践仍然是一个未解决的临床的问题。增加的证据建议糖尿病 mellitus (DM ) 是为 ISR，而是在... 详细信息

BackgroundPercutaneous 冠的干预(一种总线标准) 为冠的动脉疾病(CAD ) 成为了主要治疗学的过程，但是 in-stent 狭窄(ISR ) 的高率在临床的实践仍然是一个未解决的临床的问题。增加的证据建议糖尿病 mellitus (DM ) 是为 ISR，而是在有 DM 的 CAD 病人的 ISR 的风险预言者的一个主要风险因素一直不好描绘。这研究的目的是调查临床并且 angiographic 特征预言者显著地在与 drug-eluting stent ( des )跟随冠的 stenting 的糖尿病的病人与 ISR 的出现联系了诊断了 CAD 并且在北京 Anzhen 经历了冠的 des 培植的有糖尿病的 920 个病人的 .MethodsA 总数在中国的医院连续地从2012年1月注册了到2012年12月。这些， 440 个病人由于对待的目标损害的前进在 6 个月以内经历了第二 angiography。最后，满足了包括和排除标准的 368 个这些病人被跟随在上面由在基线一种总线标准以后的 angiography。根据是否 ISR 在后续 angiography 被检测，病人们被划分成 ISR 组(n = 74 ) 并且 non-ISR 组(n = 294 ) 。在有 DM 的病人的 ISR 的独立预言者被有一个平均数的 368 个病人(260 个女人和 108 个男人) 全部的回归 models.ResultsA 58.71 变老的 multivariate 艇长比例的危险探索#

关键词：糖尿病预言狭窄总线标准风险因素 ISR des 回归模型

Long term outcomes of drug-eluting stent versus coronary artery bypass grafting for left main coronary artery disease： a meta-analysis

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Journal of Geriatric Cardiology 2018年第2期15卷 162-172页

作者： Kong-Yong CUI Shu-Zheng LYU Xian-Tao SONG Fei YUAN Feng XU Min ZHANG Ming-Duo ZHANG Wei WANG Dong-Feng ZHANG Jing DAI Jin-Fan TIAN Yun-Lu WANG Department of Cardiology Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China Department of Anesthesiology Beijing Chaoyang Hospital Capital Medical University Beijing China

BackgroundIt 仍然是争论的有 drug-eluting stent ( des )的经皮的冠的干预是否与冠的动脉相比安全、有效为没有防卫的左主要冠的动脉( ULMCA )绕过接枝外科( CABG )疾病在长期列在后面在上面( 3 年) .MethodsEligible 研究被寻找 Pub... 详细信息

BackgroundIt 仍然是争论的有 drug-eluting stent ( des )的经皮的冠的干预是否与冠的动脉相比安全、有效为没有防卫的左主要冠的动脉( ULMCA )绕过接枝外科( CABG )疾病在长期列在后面在上面( 3 年) .MethodsEligible 研究被寻找 PubMed 选择， EMBASE ，并且 Cochrane 图书馆直到2016年12月6日。主要端点是一死亡，心肌的梗塞(MI ) 或在最长的后续期间的击合成。死亡，心脏的死亡， MI，击和重复 revascularization 是第二等的 outcomes.ResultsFour 使随机化的控制试用和包含 14,130 个病人的 12 调整观察研究被包括。des 比得上关于主要端点的出现的 CABG (HR = 0.94， 95% CI：0.86-1.03 ) 。而且， des 显著地与 MI 的更高的发生被联系(HR = 1.56， 95% CI：1.09-2.22 ) 并且重复 revascularization (HR = 3.09， 95% CI：2.33-4.10 ) 当没有差别在二策略之间被发现时，与 CABG 相比认为是死亡，心脏的死亡和击的率。而且， des 能减少死亡， MI 或击的合成端点的风险(HR = 0.80， 95% CI：0.67-0.95 ) 因为有句法的 ULMCA 损害与重复 revascularization 的更高的风险获得 32 .ConclusionsAlthough，有 des 的一种总线标准看起来象为 ULMCA 疾病在的 CABG 一样安全长期列在后面起来。另外，有 des 的治疗能是到为 ULMCA 损害与的 CABG 的其他的 interventional 策略对中间的解剖复杂性低。

关键词：动脉疾病 PubMed des 总线标准死亡 CI 图书馆

Non-profiled Deep-Learning-Based Power Analysis of the SM4 and des Algorithms

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Chinese Journal of Electronics 2021年第3期30卷 500-507页

作者： MA Xiangliang LI Bing WANG Hong WU Di ZHANG Lizhen HUANG Kezhen DUAN Xiaoyi School of Integrated Circuits Tsinghua University National Research Center for Information Technology Security China Cybersecurity Review Technology and Certification Center Trusted Computing and Information Assurance Laboratory Institute of Software Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Electronics and Information Engineering Beijing Electronic Science and Technology Institute

Power analysis methods are commonly used for evaluating the security of cryptographic devices.They are characteristically low-cost and display a high success rate and the ability to obtain important device information, e.g., keys. Given the current wide application of deep-learning technology, there is a growing tendency to incorporate power-analysis technology in development.This study investigates non-profiled deep-learning-based power analysis. The labels used in this attack are uncertain,and the attack conditions required are greatly reduced. We choose the Recurrent neural network(RNN), multilayer perceptron, and convolutional neural network algorithms,which use the same network structure, to recover the keys for the SM4 software and des hardware implementations.We propose combining the RNN algorithm with power analysis, and validate the benefits experimentally. The experimental results show that they all successfully recover the correct key for the SM4 software implementation,although the RNN algorithm by itself achieves a better effect. This conclusion also applies to attacks on the des hardware implementation but is limited to labels based on the bit model.

关键词： Cryptography Data security Neural nets Non-profiled deep learning Power analysis SM4 des Key recovery

Vessel healings after stenting with different polymers in STEMI patients

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Journal of Geriatric Cardiology 2016年第4期13卷 306-311页

作者： Qin-Hua JIN Yun-Dai CHEN Feng TIAN Jun GUO Jing JING Zhi-Jun SUN Department of Cardiology Chinese PLA General Hospital Beijing China

在心肌的梗塞(STEMI ) 病人可以影响的圣片断举起的 BackgroundDifferent stents 培植由在 stenting 以后影响容器愈合的长期的预后。学习是与尖锐 STEMI.MethodsThis 学习在病人与可被细菌破坏或持久的聚合物或赤裸金属的 stents ( BM... 详细信息

在心肌的梗塞(STEMI ) 病人可以影响的圣片断举起的 BackgroundDifferent stents 培植由在 stenting 以后影响容器愈合的长期的预后。学习是与尖锐 STEMI.MethodsThis 学习在病人与可被细菌破坏或持久的聚合物或赤裸金属的 stents ( BMS )在药 eluting stents ( des )的培植以后评估容器愈合的这的目的包括了 50 个病人，谁经历了在 angiogram 和光连贯断层摄影术(10月)上面列在后面评价在为 STEMI 的经皮的冠的干预(一种总线标准)以后的大约一年。根据起始的 stents 类型，这些病人被分类到持久(n = 19 ) 或可被细菌破坏的聚合物 sirolimus-eluting stents (n = 15 ) ，或 BMS (n = 16 ) 组。stent 神气范围和 malapposition 的条件与 9003 口神气全部的 10 月 technique.ResultsA 被分析被分析：3299， 3202 和 2502 从持久或可被细菌破坏的聚合物 des，或 BMS 分别地。神气范围率(89.0% ， 94.9% 和 99.3% ，分别地) ， malapposition 存在(1.7% 神气， 0.03% 和 0，分别地) 并且在神气上的平均内层的厚度(76 ±；12 µ； m， 161 ±；30 µ； m 和 292 ±；29 µ； m，分别地) 在不同 stent 组之中是显著地不同的(所有 P <；0.001 ) 在 STEMI 病人的 .ConclusionsVessel 愈合地位比持久的聚合物 des 在可被细菌破坏的聚合物 des 的培植以后是优异的，当两个低于 BMS 时。

关键词：血管支架聚合物患者治疗可生物降解光学相干断层成像 BMS des

在斜向非定常流动中由层流向湍流转变对模型尺度螺旋桨性能和压力脉动的影响

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哈尔滨工程大学学报（英文版） 2023年第2期22卷 199-218页

作者： Stefano Gaggero University of Genoa Department of ElectricElectronicTelecommunications Engineering and Naval ArchitectureVia Montallegro 1Genoa 16145Italy

In this paper,after the successful applications to open water propeller performance estimations,the influence of transition sensitive and modified mass transfer models tuned to account for the laminar flow in the prediction of the cavitation inception of marine propulsors is investigated from the point of view of the unsteady functioning and induced pressure pulses.The VP1304(also known as PPTC)test case,for which dedicated data were collected during several workshops,is considered first.After preliminary analyses using RANS,also Detached Eddy Simulations(des)are included to better account for the vortex dynamics and its influence on pressure pulses.Similarly to what observed in uniform inflow,results show a better agreement with the available measurements of propeller performances and confirm the reliability of the proposed approaches for unsteady,non-cavitating,model scale propeller predictions.The overall cavitation pattern is improved too by the application of the transition sensitive correction to the mass transfer model,but the complex dynamics of bubble cavitation observed in experiments prevents quantitatively better predictions in terms of thrust/torque breakdown and induced pressure pulses levels regardless the use of RANS or des methods.

关键词： Transition sensitive turbulence models Cavitation Cavitation with laminar flow Mass transfer models Model scale propeller Oblique flow Induced pressure pulses RANS des

三元des预处理杨木屑促进纤维素酶水解的研究

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中国造纸学报 2022年第4期37卷 25-30页

作者：管春龙徐烨轩卞辉洋周雪莲戴红旗南京林业大学轻工与食品学院江苏南京210037

采用由对甲基苯磺酸、氯化胆碱和乙醇组成的新型三元低共熔溶剂(des)对杨木屑进行预处理,研究了三元des预处理对杨木屑木质纤维化学组分、微观形态、结晶结构、化学结构及纤维素酶水解效果的影响。结果表明,和杨木屑原料相比,二元des预... 详细信息

采用由对甲基苯磺酸、氯化胆碱和乙醇组成的新型三元低共熔溶剂(des)对杨木屑进行预处理,研究了三元des预处理对杨木屑木质纤维化学组分、微观形态、结晶结构、化学结构及纤维素酶水解效果的影响。结果表明,和杨木屑原料相比,二元des预处理物料的木质素脱除率不升反降,而添加乙醇的三元des预处理物料的木质素脱除率提高至69.2%;三元des体系可有效抑制物料表面酸不溶物质的形成,减少纤维素酶的无效吸附,可将纤维素酶水解效率提高至76.6%;在三元des预处理过程中,半纤维素、木质素以及纤维素无定形区结构的破坏导致纤维素结晶度由原料的48.7%提高至65.7%,纤维素结晶指数由0.66提高至0.76。

关键词： des 预处理酶水解结晶度结晶指数