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Economic Burden of Disability Adjusted Life Years(dalys)of Injuries

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Health 2015年第4期7卷 487-494页

作者： Koustuv Dalal Leif Svanstrom Centre for Injury Prevention and Safety Promotion(CIPSP) School of Health&Medical SciencesDepartment of Public Health ScienceOrebro UniversityOrebroSweden Department of Public Health Sciences School of Life SciencesUniversity of SkovdeSkovdeSweden Division of Social Medicine Department of Public Health SciencesKarolinska InstituteStockholmSweden

Economic burdens of injuries at the country level are unknown. In the current study we tried to explore the economic burden of dalys loss due to injuries at the country level, then distributed according to the World Bank’s income groups. Methods: Data from the World Bank and the World Health Organization websites were used. Disability adjusted life year (DALY) and gross domestic product (GDP) per capita were used to estimate the economic loss for RTIs. Estimates of economic burdens were presented in tables and figures. Results: The total economic loss of the world during 2004 by means of dalys due to injuries was 613. 144 billion USD, corresponding value of 848.205 billion USD in 2014. dalys burden of injuries were concentrated (almost 75%) among low and lower middle income countries. Economic burdens of injuries were concentrated (over 80%) among higher middle and high income countries. Iraq had lost almost one-fifth of its GDP due to injuries. The USA had the highest amount of economic loss for injuries (169.136 billion USD) among all countries. Conclusion: Injuries are highly expensive and they account for heavy losses to GDP. Injury prevention should be prioritized in order to save such losses to life and economies.

关键词： Costs dalys Injuries Income Group

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dalys公式中年龄权数的探讨

现代预防医学 2007年第22期34卷 4292-4294页

作者：周尚成蔡乐万崇华何利平郧阳医学院公共事业管理系昆明医学院公共卫生学院

[目的]研究公用dalys公式中年龄权数。[方法]采用数理统计方法进行推理并结合实例演算。[结果]dalys公式中年龄权数中β、K等参数的变化对dalys影响很大。[结论]加强dalys公式中参数的本土化研究很有必要。

关键词： dalys 年龄权数全球疾病负担研究

1990-2019年我国2型糖尿病dalys发展趋势的分析与预测

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中国卫生统计 2023年第5期40卷 741-743,747页

作者：任梦悦贾琳王楠韩松王雨沈阳医学院流行病学与卫生统计学教研室 110034 沈阳海关沈阳医学院研究生院

目的基于GBD(global burden disease)2019年最新数据,分析我国2型糖尿病及归因危险因素导致的dalys的现况和变化趋势,预测2020-2024年疾病发展情况。方法下载GBD中描述2型糖尿病及归因危险因素的dalys,采用Joinpoint分析变化趋势,借助灰... 详细信息

目的基于GBD(global burden disease)2019年最新数据,分析我国2型糖尿病及归因危险因素导致的dalys的现况和变化趋势,预测2020-2024年疾病发展情况。方法下载GBD中描述2型糖尿病及归因危险因素的dalys,采用Joinpoint分析变化趋势,借助灰色GM(1,1)模型,预测2020-2024年疾病发展状况。结果2019年2型糖尿病dalys-number、Rate较1990年分别增长145.36%、9.34%;高BMI是2型糖尿病dalys主要危险因素,归因占比38.06%。2型糖尿病标化dalys-Rate整体为上升趋势,其中2004-2019年为下降段,APC=-0.87%;归因高BMI的标化dalys-Rate持续上升,AAPC=2.8%。2型糖尿病不同趋势段的预测显示,到2024年dalys-Rate分别是531.49/10万、447.17/10万。归因高BMI预测到2024年dalys-Rate将达到212.03/10万。结论2型糖尿病dalys有所下降,应持续加强防控措施;随着人口肥胖率的明显增高,若不及时进行干预,由高BMI导致的dalys将进一步加重。

关键词： 2型糖尿病 dalys 变化趋势预测

2015年泰安市居民恶性肿瘤死亡与dalys研究

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2015年泰安市居民恶性肿瘤死亡与DALYs研究

作者：王杰泰山医学院

学位级别：硕士

研究背景随着社会经济的发展、生活环境的变化、生活水平的提高、生活方式的改变以及人口老龄化等因素变化,20世纪以来,世界多数国家的疾病谱发生转型,从以传染病为主要疾病负担转向以非传染性疾病为主要疾病负担,心脑血管疾病、恶性肿... 详细信息

研究背景随着社会经济的发展、生活环境的变化、生活水平的提高、生活方式的改变以及人口老龄化等因素变化,20世纪以来,世界多数国家的疾病谱发生转型,从以传染病为主要疾病负担转向以非传染性疾病为主要疾病负担,心脑血管疾病、恶性肿瘤等慢性病成为严重威胁居民生命和健康的主要疾病。根据世界卫生组织国际癌症研究中心(IARC,WHO)报道,20世纪70年代以后,全球恶性肿瘤的发病率与死亡率均以3%的增速不断升高。全世界死亡人口中有八分之一的人是死于癌症。在世界范围内,癌症造成的死亡比艾滋病、肺结核和疟疾加起来还要多。癌症是发达国家的第二大死亡原因(仅次于心脏病)和发展中国家第三大死亡原因(仅次于心脏病和腹泻病),是目前全球最严重的公共卫生问题之一。1993-1996年,美国哈佛大学在世界银行、世界卫生组织的资助下开展了关于全球疾病负担(Global Burden of Disease,GBD)评价的研究,首次使用疾病负担的概念。各国学者经过多年研究后,对于疾病负担的定义最终达成共识,疾病负担是指疾病给人类社会造成损失的总和,其中包括疾病伤残、失能、死亡、生活质量下降、其他经济损失等为防治疾病而消耗的社会资源。国内对疾病负担的分类主要有两种,分为疾病的流行病学负担和疾病经济负担。发展至今,疾病的流行病学负担相关指标可分为两大类:健康期望和健康差距。前者代表性指标包括人均期望寿命、健康期望寿命、伤残调整期望寿命和质量调整期望寿命;健康差距的代表性指标为伤残调整寿命年。目的对泰安市2015年居民恶性肿瘤死亡资料进行分析,了解恶性肿瘤的死亡状况以及去肿瘤死因寿命,计算并描述不同人群、地区和恶性肿瘤病种的伤残调整寿命年分布,以较为全面、综合地评价恶性肿瘤的健康负担,为卫生决策者制定卫生策略提供科学依据。方法根据2015年泰安市居民恶性肿瘤死亡监测资料,用死亡率、死因别死亡率、年龄别死亡率、年龄调整死亡率等指标描述居民恶性肿瘤死亡水平,并采用期望寿命表计算期望寿命及恶性肿瘤去死因期望寿命。采用国际疾病分类ICD-10进行根本死因编码。dalys的计算按照GBD提供的公式计算,计算过程中采用标准期望寿命、3%的贴现率和4%的标准年龄权重。人口标化率计算以2000年中国标准人口进行标化;运用SPSS20.0进行数据分析,死亡率的比较采用χ检验。结果1.2015年泰安市平均人口数为5648091人,65岁以上人口构成比13.38%,老年负担系数为18.73%。2015年泰安市总体人口期望寿命为79.86岁,男性期望寿命为76.58岁,女性期望寿命为83.37岁,女性明显高于男性。岱岳区人口期望寿命最高,为81.11岁,宁阳县的人口期望寿命最低,为78.06岁。2015年泰安市户籍居民死亡率为7.42‰,标化死亡率为5.20‰,其中肥城市的标化死亡率最高,为5.94‰,东平县最低,为5.04‰。2.2015年泰安市居民恶性肿瘤报告死亡数12510例,死亡率221.48/10万,标化率为122.20/10万,死因顺位前5位依次为肺癌、食管癌、胃癌、肝癌、结直肠癌。恶性肿瘤的死亡率存在明显的性别差异,男性粗死亡率287.80/10万,女性粗死亡率153.42/10万,男性显著高于女性(χ=1153.41,P<0.001)。泰安市城乡恶性肿瘤死因顺位有所不同,城市死因顺位前十位,分别为肺癌、胃癌、肝癌、食道癌、结直肠癌、乳腺癌、胰腺癌、膀胱癌、白血病、子宫颈癌;农村死因顺位前十位,分别为肺癌、食道癌、胃癌、肝癌、结直肠癌、乳腺癌、淋巴瘤与多发性骨髓瘤、白血病、胰腺癌、子宫颈癌。其中标化死亡率差异最大的是食道癌与膀胱癌,食道癌标化率农村(25.23/10万)为城市(10.61/10万)的2.38倍,膀胱癌城市(1.74/10万)为农村(0.84/10万)的2.07倍。去恶性肿瘤死因后全人群期望寿命为84.14岁,增加了4.28岁;男性为81.59,增加5.01岁;女性为86.63岁,增加3.27岁。3.2015年泰安市居民肺癌共死亡3717例,死亡率为65.81/10万,男性死亡率为88.36/10万,女性死亡率为42.66/10万,男性死亡率明显高于女性且差异具有统计学意义(χ=448.27,P<0.001)。泰安市肺癌地区分布明显,六个县市区肺癌死亡率差异具有统计学意义(χ=107.57,P<0.001),死亡率最高的是新泰市,为43.58/10万。去肺癌死因后泰安市全人群期望寿命为81岁,增加了1.14岁;男性为77.92,增加1.34岁;女性为84.21岁,增加0.84岁。新泰市去肺癌死因后人群期望寿命为81.19岁,增加了1.44岁。4.2015年泰安市居民食管癌共死亡2221例,死亡率为39.32/10万,男性死亡率为55.64/10万,女性死亡率为22.

关键词：恶性肿瘤肺癌食管癌死亡率 dalys

dalys及其在疾病负担与成本效果分析中的应用

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广东卫生防疫 2001年第3期27卷 19-23页

作者：庄润森王声湧暨南大学医学院流行病学教研室 510632

疾病预防与控制的决策依据来自于疾病对健康危害程度的各种信息[1].评价疾病危害程度的大小,需要一定的指标.通常使用死亡率、发病率、患病率、潜在寿命损失年(YPLLs)及其构成比等指标计算.

关键词： dalys 疾病负担成本效果分析疾病预防疾病统计

The burden of mental health in lymphatic filariasis

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Infectious Diseases of Poverty 2015年第1期4卷 275-282页

作者： Thanh G.N.Ton Charles Mackenzie David H.Molyneux Precision Health Economics 55512 th AvenueSuite 1650OaklandCA 94607USA Filariasis Programmes Support Unit Department of ParasitologyLiverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK LSTM NTDs Department of ParasitologyLiverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK

Background:Neglected Tropical Diseases(NTDs)afflict around one billion individuals in the poorest parts of the world with many more at *** filariasis is one of the most prevalent of the infections and causes significant morbidity in those who suffer the clinical conditions,particularly lymphedema and *** illness has been recognised as a prevalent disability in those with the disease because of the stigmatising nature of the *** estimates of the burden of depressive illness of any neglected tropical disease have been undertaken to date despite the recognition that such diseases have major consequences for mental health not only for patients but also their ***:We developed a mathematical model to calculate the burden of Disability-Adjusted Life Years(DALY)attributable to depressive illness in lymphatic filariasis and that of their caregivers using standard methods for calculating *** of numbers with clinical disease was based on published estimates in 2012 and the numbers with depressive illness from the available ***:We calculated that the burden of depressive illness in filariasis patients was 5.09 million disability-adjusted life years(dalys)and 229,537 dalys attributable to their *** figures are around twice that of 2.78 million dalys attributed to filariasis by the Global Burden of Disease study of ***:Lymphatic filariasis and other neglected tropical diseases,notably Buruli Ulcer,cutaneous leishmaniasis,leprosy,yaws,onchocerciasis and trachoma cause significant co morbidity associated with mental illness in *** to assess the prevalence of the burden of this co-morbidity should be incorporated into any future assessment of the Global Burden of neglected tropical *** prevalence of depressive illness in caregivers who support those who suffer from these conditions is *** assessments are critical for neglected tropical diseases whi

关键词： Lymphatic filariasis Mental health Global burden of disease dalys Filariasis morbidity Caregivers

Incidence, mortality, and disability-adjusted life years of female breast cancer in China, 2022

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中华医学杂志(英文版) 2024年第20期137卷 2429-2436页

作者： Sun Kexin Zhang Bailin Lei Shaoyuan Zheng Rongshou Liang Xin Li Li Feng Xiaolong Zhang Siwei Zeng Hongmei Yao Yifei Ma Peiqing Wang Shaoming Chen Ru Han Bingfeng Wei Wenqiang He Jie Office of Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Evidence-Based Medicine Xuanwu Hospital Capital Medical University Beijing China Medical Statistics Office National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Background: Breast cancer is ranked among the most prevalent malignancies in the Chinese female population. However, comprehensive reports detailing the latest epidemiological data and attributable disease burden have not been extensively ***: In 2018, high-quality cancer surveillance data were recorded in 700 population-based cancer registries in China. We extracted data on female breast cancers (International Classification of Diseases, Tenth Revision [ICD-10]: C50) and estimated the incidence and mortality in 2022 according to the baseline data and corresponding trends from 2010 to 2018. Pathological types were classified according to the ICD for Oncology, 3rd Edition codes. Disability-adjusted life years (dalys) were calculated as the sum of the years of life lost (YLLs) and years lived with disability (YLDs).Results: In 2022, approximately 357,200 new female breast cancer cases and 75,000 deaths occurred in China, accounting for 15.59% and 7.94% of total new cancer cases and deaths, respectively. The age-standardized incidence rate (ASIR) was 33.04 per 100,000. When analyzed by pathological type, the ASIRs for papillary neoplasms, invasive breast carcinoma, rare and salivary gland-type tumors, and other types were 1.13, 29.79, 0.24, and 1.88 per 100,000, respectively. The age-standardized mortality rate (ASMR) was 6.10 per 100,000. A total of 2,628,000 dalys were found to be attributable to female breast cancer in China, comprising 2,278,300 YLLs and 349,700 YLDs. The ASIR, ASMR, and age-standardized rate (ASR) for dalys in urban areas were consistently higher than those in rural areas. We observed a four-fold increase in the ASIR and ASR for dalys and an eight-fold increase in the ASMR among females over 55 years compared with those aged under 55 ***: These data provide invaluable insights into the latest epidemiology of female breast cancer in China and highlight the urgency for disease prevention and control strategy formulation.

关键词： Female Breast cancer Incidence Mortality dalys China Early detection of cancer Disease burden Invasive breast carcinoma Quality of life

Burden of pancreatitis and associated risk factors in China,1990 to 2019:a systematic analysis for the Global Burden of Disease Study 2019

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Chinese Medical Journal 2022年第11期135卷 1340-1347页

作者： Ke Han Shimin Chen Yang Song Chen Du Fei Gao Shaohua Liu Yao He Ningli Chai Enqiang Linghu Miao Liu Department of Gastroenterology First Medical Center of Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China Institute of Geriatrics Beijing Key Laboratory of Aging and GeriatricsNational Clinical Research Center for Geriatric DiseaseSecond Medical Center of Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China Graduate School Chinese PLA General Hospital and Chinese PLA Medical SchoolBeijing 100853China.

Background: Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to ***: This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (dalys) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and dalys, which are attributable to alcohol use by age and ***: From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized dalys of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized dalys caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in ***: The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancr

关键词： Alcohol use Global disease burden Incidence Mortality dalys Pancreatitis China

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非洲主要寄生虫病的疾病负担与防控挑战

中国血吸虫病防治杂志 2018年第2期30卷 226-231页

作者：李伊婷任光辉梁幼生杨坤孙乐平李石柱吕山贾铁武中国疾病预防控制中心寄生虫病预防控制所世界卫生组织热带病合作中心国家卫生和计划生育委员会寄生虫病原与媒介生物学重点实验室上海200025 湖南省血吸虫病防治所江苏省血吸虫病防治研究所

寄生虫病是与贫穷密切相关的感染性疾病,主要流行于热带、亚热带地区。非洲是寄生虫病的主要流行区,非洲疟疾、血吸虫病疾病负担的全球占比均超过了85%。本文就非洲地区主要寄生虫病的疾病负担、地区分布与防控策略进行综述,旨在推动这... 详细信息

寄生虫病是与贫穷密切相关的感染性疾病,主要流行于热带、亚热带地区。非洲是寄生虫病的主要流行区,非洲疟疾、血吸虫病疾病负担的全球占比均超过了85%。本文就非洲地区主要寄生虫病的疾病负担、地区分布与防控策略进行综述,旨在推动这一区域寄生虫病防治进程。

关键词：寄生虫病被忽视热带病疾病负担非洲 dalys 防控策略