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中国药理通讯 2006年第4期23卷 23-24页

作者： Gao Ming Liu Chang- Liang Chu Hong- Yuan Yang Shen Shi Wei -Xing Jin Guo- Zhang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaShanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203

Aim: To investigate the functional correlation between medial prefrontal cortex (mPFC) and ventral tegmental area (VTA). Methods : VTA da neurons firing and PFC local field potential (LFPs) were simultaneously recorded with multisites recording in chloral hydrate - anesthetized rats. Results: Based on the relative amplitude of the slow oscillation ( SO), we divided VTA da neurons into two groups : high SO (HS) and low SO (LS). Nearly half of 232 (47%) VTA da neurons were HS cells because the mean power between 0. 5 - 1.5Hz (P0. 5-1. 5Hz ) in their autospectra was significantly higher than that between 0 -3Hz (P0-3Hz). In most VTA da cells (67%), the SO was significantly coherent with mPFC LFPs with a high coherence. We refer to these da neurons as PFC - coupled (PC) cells, which included both high SO (HS) and low SO (LS) cells, mPFC inactivation induced by TTX local infusion significantly decreased the SO in most cells tested (27/29), and had no significant effect on firing rate and bursting. Compared to non - lesioned rats, mPFC transection markedly decreased both the number of HS cells and the amplitude of the SO. Phase analysis between VTA da neuron firing and mPFC LFPs suggests that the SO in most da neurons has a nearly anti - phase relation with PFC oscilla- tions and the phase lag between the SO and PFC was greater than 40% of a cycle period. In most PFC pyramidal neurons,

关键词：中枢神经中脑腹侧被盖区前额叶皮质 da神经活性功能相关性细胞周期

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