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Preparation and immunoprotective effects of a virus-like particle candidate vaccine of the dominant epidemic d3 genotype coxsackievirus A6 in China

引用

Biosafety and Health 2024年第1期6卷 28-34页

作者： Xiaoliang Li Xizhu Xu Jichen Li Huanhuan Lu Congcong Wang Rui Wang Jinbo Xiao Ying Liu Yang Song Jingdong Song Qiang Sun Yong Zhang department of Public Health and Health Administration Shandong First Medical UniversityJinan 250117China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases(NITFId) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Polio Laboratory WHO WPRO Regional Polio Reference LaboratoryNational Health Commission Key Laboratory for BiosafetyNational Health Commission Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBejing 102206China department of Medical Microbiology Weifang Medical UniversityWeifang 261053China

Coxsackievirus A6 of the d3a genotype(CVA6 d3a)is a primary pathogen causingmainland of China's hand,foot,and mouth disease(HFMd).Viral‐like particle(VLP)vaccines represent a potential candidate vaccine to prevent *** study collected Anti‐CVA6 d3a VLPs serum from BALB/c female mice immunized using CVA6 d3a *** neutralizing antibody levels were compared against the representative 14‐JX2018(d3a)and N4‐YN2015(d3b)strains between the antisera of different immune *** immunoprotective effect of anti‐CVA6 d3a VLPs against these strains was monitored using pathological sections and immuno-histochemical results of lung and skeletal muscle tissues in seven‐day‐old Institute of Cancer Research(ICR)*** protection against different branches of viruses was evaluated in 7‐day‐old(serum passive immune protection)and 14‐day‐old(VLPs active immune protection)neonatal ICR mice ***‐neutralizing antibody levels were positively correlated with the number of immunizations and higher against 14‐JX2018 than against N4‐***,these levels were significantly higher with abdominal injection than intramuscular *** immunized serum of 7‐day‐old ICR mice inoculated three times was 100%protected against CVA6 d3a 14‐JX2018(lethal titer:106.25 TCId 50)and CVA6 d3b N4‐YN2015(lethal titer:105.25TCId 50)fatal attacks,*** ICR mice that have completed two active immunizations for 14 days,both CVA6 d3a 14‐JX2015(challenge titer:108.25 TCId 50)and CVA6 d3b N4‐YN2015(challenge titer:107.25 TCId 50)were used for the challenge,and the mice were able to ***,the CVA6 d3a VLPs prepared in this study are a potential vaccine candidate for CVA6,as it has the optimal protective effect against both CVA6 d3a and d3b evolutionary branches viruses.

关键词： Coxsackievirus A6 d3 genotype Virus‐like particle Immunoprotective effect

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