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Effects of Ovariectomy and 17β-Estradiol Replacement on the Activity of dopamine d2 receptors in the Selection of Macronutrients Carbohydrates, Lipids and Proteins in Females Rats

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Journal of Biosciences and Medicines 2023年第5期11卷 76-110页

作者： Brahima Bamba Seydou Silué Tiémélé Eugène Atayi Antoine Némé Tako Laboratoire de Neurosciences UFR Biosciences Université Félix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Service de Neurologie UFR Des Sciences Médicales Centre Hospitalier et Universitaire (CHU) de Cocody Abidjan C&ocircte d’Ivoire

17β-estradiol modulates the activity of d2 receptors in the regulation of food intake and body weight. The functional lack of 17β-estradiol in postmenopausal women could create a dietary imbalance and cause body weight gain. This study aimed to better understand the interferences that could exist between 17β-estradiol, d2 receptors and the selection of carbohydrate, fat and protein consumption, as well as their consequences on body weight gain by using an animal model of the menopause. Ovariectomy exacerbates the consumption of foods rich in lipids. Thus confirming an inhibitory action of 17β-estradiol (E2) on the consumption of these types of foods. This consumption stimulates body weight gain, which is promoted by the high caloric content of these foods and not by the amount consumed. Our results showed a direct involvement of d2 receptors in food choice. This choice would be made according to the two (2) isoforms of the d2 receptors. The d2/BR isoform directs towards a high carbohydrate consumption, without causing a gain in body weight. While d2/SUL, promotes high fat food consumption, causing an increase in body weight. In women, 17β-estradiol modulates the activity ratio between these two d2 receptor isoforms to ensure energy and homeostatic balance, stabilizing food intake and body weight.

关键词： 17β-Estradiol d2 receptors Bromocriptine Sulpiride Carbohydrates Lipids Proteins Body Weight Menopause Obesity

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Renal dopaminergic system:Pathophysiological implications and clinical perspectives

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World Journal of Nephrology 2015年第2期4卷 196-212页

作者： Marcelo Roberto Choi Nicolás Martín Kouyoumdzian Natalia Lucía Rukavina Mikusic María Cecilia Kravetz María Inés Rosón Martín Rodríguez Fermepin Belisario Enrique Fernández department of Anatomy and Histology Faculty of Pharmacy and BiochemistryUniversity of Buenos AiresCONICETINFIBIOC department of Pathophysiology Faculty of Pharmacy and BiochemistryUniversity of Buenos AiresCONICETINFIBIOC

Fluid homeostasis, blood pressure and redox balance in the kidney are regulated by an intricate interaction between local and systemic anti-natriuretic and natriuretic systems. Intrarenal dopamine plays a central role on this interactive network. By activating specifc receptors, dopamine promotes sodium excretion and stimulates anti-oxidant and anti-inflammatory pathways. different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome, hypertension and renal infammation, can be associated with impaired action of renal dopamine including alteration in biosynthesis, dopamine receptor expression and signal transduction. Given its properties on the regulation of renal blood fow and sodium excretion, exogenous dopamine has been postulated as a potential therapeutic strategy to preventrenal failure in critically ill patients. The aim of this review is to update and discuss on the most recent findings about renal dopaminergic system and its role in several diseases involving the kidneys and the potential use of dopamine as a nephroprotective agent.

关键词： dopamine Hypertension kidney Na+, K+-ATPase Sodium Oxidative stress d1 receptors d2 receptors Renal failure Edema

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