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作者： MAC SANdRIE MARIELLA 重庆医科大学

学位级别：硕士

For many decades,d2 procedure has been accepted in Far East as the standard treatment for both early(EGC)and advanced gastric cancer(AGC).In case of AGC,the debate on the extent of nodal dissection has been open for many years in order to highlight the safety and efficacy of treatment,hence this study.A comprehensive literature research was performed in PubMed to identify studies that compared laparoscopic-assisted gastrectomy(LAG)and open gastrectomy(OG)with d2 lymph node dissection(d2-LNd)for treatment of AGC for the last five *** of interest were checked and subjected to meta-analysis with RevMan 5.3 *** pooled risk ratios(RR)and weighted mean difference(WMd)with 95%confidence intervals(CI)were ***,19 studies were included in this *** had some advantages over OG,including shorter hospitalization(WMd-2.31;95%CI-4.09 to-0.53;P = 0.01),less blood loss(WMd-120.49;95%CI-174.27 to-66.71;Pd-0.55;95%CI-0.86 to-0.24;P 0.01)and earlier ambulation(WMd-0.75;95%CI-1.38 to-0.11;P = 0.02).In terms of surgical and oncological safety,LG could achieve similar lymph nodes(WMd,-0.94,95%CI,-2.95 to 1.06;P＝0.36),a lower complication rate[odds ratio(OR),0.80;95%CI 0.68,0.97;P = 0.02],and overall survival(OS)and disease-free survival(dFS)comparable to *** conclusion:for AGCs,both techniques(LAG and OG)appeared comparable in short-and long-term *** time was needed to perform LAG;nonetheless,it had some advantages in achieving faster postoperative recovery over *** order to clarify this controversial issue ongoing trials and future studies are needed.

关键词： Advanced gastric cancer Laparoscopic gastrectomy Open gastrectomy d2 lymph node dissection meta-analysis

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Survival prognostic analysis of laparoscopic d2 radical resection for locally advanced gastric cancer: A multicenter cohort study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2451-2460页

作者： Xiu-Ming Sun Kui Liu Wen Wu Chao Meng department of Pain Management Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina department of Hepatobiliary Surgery Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUNd With the development of minimally invasive surgical techniques,the use of laparoscopic d2 radical surgery for the treatment of locally advanced gastric cancer(GC)has gradually ***,the effect of this procedure on survival and prognosis remains *** study evaluated the survival and prognosis of patients receiving laparoscopic d2 radical resection for the treatment of locally advanced GC to provide more reliable clinical evidence,guide clinical decision-making,optimize treatment strategies,and improve the survival rate and quality of life of *** A retrospective cohort study was *** data from 652 patients with locally advanced GC in our hospitals from december 2013 to december 2023 were *** were 442 males and 210 *** mean age was 57±12 *** patients underwent a laparoscopic d2 radical operation for distal *** patients were followed up in the outpatient department and by telephone to determine their tumor recurrence,metastasis,and *** follow-up period ended in december *** distributed data are expressed as the mean±Sd,and normally distributed data are expressed as M(Q1,Q3)or M(range).Statistical data are expressed as absolute numbers or percentages;theχ2 test was used for comparisons between groups,and the Mann-Whitney U nonparametric test was used for comparisons of rank *** life table method was used to calculate the survival rate,the Kaplan-Meier method was used to construct survival curves,the log rank test was used for survival analysis,and the Cox risk regression model was used for univariate and multifactor *** The median overall survival(OS)time for the 652 patients was 81 months,with a 10-year OS rate of 46.1%.Patients with TNM stages II and III had 10-year OS rates of 59.6%and 37.5%,respectively,which were significantly different(Pdicated that factors such as age,maximum tumor diameter,tumor

关键词： Gastric neoplasms Chinese Laparoscopic Gastrointestinal Surgery Study Group Laparoscopic surgery Locally advanced gastric cancer d2 lymph node dissection

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Laparoscopic-assisted radical gastrectomy for distal gastric cancer

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Chinese Journal of Cancer Research 2013年第4期25卷 460-462页

作者： Yian du Xiangdong Cheng Zhiyuan Xu Litao Yang Ling Huang Bing Wang Pengfei Yu Ruizeng dong department of Abdominal Surgery Zhejiang Cancer Hospital

A 48-year-old female patient was diagnosed with a superficial depressed type early gastric cancer （type IIc） of 1.0 cm at the gastric angle as indicated by gastroscopy. Laparoscopic-assisted greater omentumpreserving d2 radical gastrectomy was performed in combination with Billroth I reconstruction under general anesthesia for the distal gastric cancer on April 5, 2013. The postoperative recovery was satisfying without complications. The patient was discharged seven days after surgery.

关键词： Early gastric cancer gastrectomy laparoscopic-assisted d2 lymph node dissection

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Laparoscopic vs open d2 gastrectomy for locally advanced gastric cancer: A meta-analysis

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World Journal of Gastroenterology 2014年第44期20卷 16750-16764页

作者： Zhen-Hong Zou Li-Ying Zhao Ting-Yu Mou Yan-Feng Hu Jiang Yu Hao Liu Hao Chen Jia-Ming Wu Sheng-Li An Guo-Xin Li department of General Surgery The Second Affiliated Hospital of Nanchang University department of General Surgery Nanfang Hospital Southern Medical University department of Biostatistics Southern Medical University

AIM: To conduct a meta-analysis comparing laparoscopic (LGd2) and open d2 gastrectomies (OGd2) for the treatment of advanced gastric cancer (AGC).

关键词： d2 lymph node dissection Gastrectomy Gastric cancer Laparoscopy Meta-analysis

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