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Application of d-optimal Study design with Contour Surface Response for designing Sustained Release Gliclazide Matrix Tablets

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Pharmacology & Pharmacy 2014年第7期5卷 620-635页

作者： Chien Nguyen John Mark Christensen Thuy Nguyen department of Pharmaceutical Sciences College of Pharmacy Oregon State University Corvallis USA National Institute of Pharmaceutical Technology Hanoi University of Pharmacy Hanoi Vietnam

An optimized formulation of a sustained release tablet of Gliclazide was developed. The use of doptimal design with a polynomial statistical model to analyze dissolution data reduced the number of laboratory tests required to obtain an optimal dosage form. The final formulation contained 22 mg of Methocel®E15LV, 16.5 mg Methocel®E15 and 10.0 mg of dibasic Calcium Phosphate per 30 mg Gliclazide sustained release tablet. dissolution studies performed on tablets from 5000 tablet test batches released greater than 90 percent of loaded drug in eight hours. drug release from the optimized tablets followed a pattern more closely similar to zero-order than other mechanisms of drug release tested. Storage of tablets in accelerated and ambient conditions for 6 and 12 months respectively did not alter any of the physico-chemical properties, drug release or the drug release rate compared to initial observations and dissolution data of the prepared tablets. The addition of potassium phosphate and monosodium phosphate to the tablet reduced the effect pH has on Gliclazide dissolution compared to the commercially available product.

关键词： Gliclazide Sustained Release d-optimal Zero-Order Response Surface Modified Release

Formulation Optimization Utilizing d-optimal Experimental design of Oral Capsules Containing Enteric-Coated Pellets of Lansoprazole and<i>in vivo </i>Bioequivalence

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Pharmacology & Pharmacy 2017年第5期8卷 153-171页

作者： Anh Quang Luong Thang Ngoc Vu dang Hoa Nguyen Sultan M. Alshahrani John Mark Christensen Chien Ngoc Nguyen department of Pharmacy National Institute of Burns Hanoi Vietnam Research and Training Center for Pharmacy Military Medical University Hanoi Vietnam Military Institute of Pharmaceutical Analysis and Research Hanoi Vietnam department of Pharmaceutics Hanoi University of Pharmacy Hanoi Vietnam department of Pharmaceutical Sciences College of Pharmacy Oregon State University Corvallis Oregon USA National Institute of Pharmaceutical Technology Hanoi University of Pharmacy Hanoi Vietnam

An optimized formulation of capsules containing Lansoprazole enteric-coated pellets using d-optimal design with a polynomial statistical model were prepared by using Eudragit?L100 as an enteric coated polymer to provide resistance to simulated gastric acid dissolution in buffer media. d-optimal experimental design was used to determine the optimal level for three coating layers that were applied to formulate the enteric-coated pellets including a drug loading layer, a sub-coating, and an outer enteric coating. dissolution studies were performed on the prepared Lansoprazole capsules. Less than 5 percent of Lansoprazole was released in 60 minutes in an acidic dissolution medium (pH 1.2) and greater than 90 percent of active ingredient was released in the next 60 minutes in a buffer dissolution medium (pH 6.8). The Lansoprazole capsules were stable with no observable change in physico-chemical properties in accelerated and normal storage conditions for 6 and 18 months, respectively. The pharmacokinetic parameters Cmax, Tmax, AUC0-t, and AUC0-∞ were determined after administration of the d-optimal design optimized capsules of LPZ to healthy beagle dogs and were statistically compared to Gastevin? capsules as a reference (KRKA, Slovenia) using the non-compartmental method with the aid of WinNonlin 5.2 software. The analysis of variance showed that the two formulations did not demonstrate bioequivalence using a 90% confidence interval range (80% - 120%) of Cmax, AUC0-t, and AUC0-∞. No significant difference in Tmax was found at the 0.95 significance level using the Wilcoxon signed-rank test. d-optimal Experimental design provided definitive direction for an optimal formulation of capsules containing enteric-coated pellets of lansoprazole loaded within the coating of pellets that provided similar bioequivalence to Gastevin.

关键词： Lansoprazole d-optimal Pellets Enteric-Coating Pharmacokinetic Parameters

A New d-optimal design Scheme for the Identification of Cubic Polynomials

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Journal of Harbin Institute of Technology(New Series) 1995年第4期2卷 24-27页

作者：李东林田自耘张宏伟郭素云

In this paper, the limitations of the single cube d-optimal design scheme is studied, and a double cube d-optimal design scheme is suggested in order to overcome the limitations. For a sort of incomplete cubic polynomials, the test design of the identification is developed with this new scheme, and the comparation with the single cube scheme is also given. This scheme is shown to be perfectly suitable for the optimal identification of the complete cubic polynomials.

关键词： ss: Identification regression optimal design d-optimal design scheme

Prediction of Natural Frequency of Laminated Composite Plates Using Artificial Neural Networks

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Engineering（科研） 2012年第6期4卷 329-337页

作者： Mutra Raja Sekhara Reddy Bathini Sidda Reddy Vanguru Nageswara Reddy Surisetty Sreenivasulu School of Mechanical Engineering R.G.M. College of Engineering & Technology Kurnool India

The paper is focused on the application of artificial neural networks (ANN) in predicting the natural frequency of laminated composite plates under clamped boundary condition. For training and testing of the ANN model, a number of finite element analyses have been carried out using d-optimal design in the design of experiments (dOE) by varying the fibre orientations, –45?, 0?, 45? and 90?. The composite plate is modeled using linear layered structural shell element. The natural frequencies were found by analyses which were done by finite element (FE) analysis software. The ANN model has been developed using multilayer perceptron (MLP) back propagation algorithm. The adequacy of the developed model is verified by coefficient of determination (R). It was found that the R2 (R: coefficient of determination) values are 1 and 0.998 for train and test data respectively. The results showed that, the training algorithm of back propagation was sufficient enough in predicting the natural frequency of laminated composite plates. To judge the ability and efficiency of the developed ANN model, absolute relative error has been used. The results predicted by ANN are in very good agreement with the finite element (FE) results. Consequently, the d-optimal design and ANN are shown to be effective in predicting the natural frequency of laminated composite plates.

关键词： dOE Laminated Composite Plates ANN MLP d-optimal design Finite Element Analysis

Formulation optimization, in situ intestinal absorption and permeability of psoralen and isopsoralen

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Chinese Herbal Medicines 2019年第3期11卷 337-343页

作者： Wan-jin Sun Peng Zhang Xiang-wei Qu Li-min Xu Chun-bao Yang Shi-ping Gu Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430061China Hubei Province Academy of Traditional Chinese Medicine Wuhan 430074China The 264 Hospital of the People’s Liberation Army Taiyuan 030000China

Objective: To optimize a self-emulsifying drug delivery system(SEddS) formulation for psoralen and isopsoralen(PSO and IPSO) isolated from Psoraleae ***: A d-optimal design was used to investigate the influence of oil percentage, surfactant percentage and cosurfactant percentage on several properties of SEddS including particle size, polydispersity,equilibrium solubility, in situ intestine absorption rate and intestinal permeability. Furthermore, the desirability function approach was applied to obtain the optimal formulation for the ***: The oil percentage, surfactant percentage and cosurfactant percentage were optimized to be53.6%, 35.7% and 10.7%, respectively, which means the model is ***: The d-optimal design is valuable to optimize the SEddS formulation and understand formulation compositions’ functions on SEddS properties.

关键词： desirability function d-optimal design isopsoralen optimization psoralen self-emulsifying drug delivery system

基于GT-Power doE的柴油机进气系统多目标多参数优化

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海军工程大学学报 2020年第5期32卷 55-60页

作者：张博张萍郭旭王银海军工程大学动力工程学院武汉430033

为进一步提升某船用柴油机的动力性、经济性和运行的可靠性,对柴油机的进气系统开展了多目标多参数的优化设计。基于柴油机工作过程及冷却系统耦合仿真模型,采用doE中d-optimal抽样方法,以普通最小二乘法建立起多个变量因子的响应面模型... 详细信息

为进一步提升某船用柴油机的动力性、经济性和运行的可靠性,对柴油机的进气系统开展了多目标多参数的优化设计。基于柴油机工作过程及冷却系统耦合仿真模型,采用doE中d-optimal抽样方法,以普通最小二乘法建立起多个变量因子的响应面模型,并采用多目标优化方法进行非归一化求解,得到额定工况下进气系统结构参数及运行参数的优化解集和最优解。仿真结果表明:优化后整机的输出功率及扭矩分别提升了3.8 kW和14.3 N·m;涡前排温、峰值缸压以及燃油消耗率分别降低了40℃,2.5 bar和2.1 g/(kW·h)。

关键词： doE GT-Power d-optimal 多目标多参数优化