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Antibacterial and cytocompatible coatings based on poly(adipic anhydride) for a Ti alloy surface

Bioactive Materials 2020年第3期5卷 709-720页

作者： Katarzyna Leśniak-Ziółkowska MonikaŚmiga-Matuszowicz Agata Blacha-Grzechnik Sebastian Student Monika Brzychczy-Włoch Małgorzata Krok-Borkowicz Elżbieta Pamuła Wojciech Simka Alicja Kazek-Kęsik Faculty of Chemistry Silesian University of TechnologyB.Krzywoustego Street 644-100GliwicePoland Faculty of Chemistry Silesian University of TechnologyM.Strzody 9 Street44-100GliwicePoland Biotechnology Centre Silesian University of TechnologyB.Krzywoustego 8 Street44-100GliwicePoland Department of Systems Biology and Engineering Faculty of Automatic ControlElectronics and Computer ScienceSilesian University of TechnologyAkademicka 16 Street44-100GliwicePoland Department of Microbiology Jagiellonian University Medical CollegeCzysta 18 Street31-121KrakowPoland Faculty of Materials Science and Ceramics AGH University of Science and TechnologyMickiewicza Av.3030-059KrakowPoland

This paper describes a formation of hybrid coatings on a Ti-2Ta-3Zr-36Nb *** is accomplished by plasma electrolytic oxidation and a dip-coating technique with poly(adipic anhydride)((C6H8O3)n)that is loaded with drugs:amoxicillin(C16H19N3O5S),cefazolin(C14H14N8O4S3)or vancomycin(C66H75Cl2N9O24·xHCl).The characteristic microstructure of the polymer was evaluated using scanning electron microscopy and confocal *** on the surface treatment,the surface roughness varied(between 1.53μm and 2.06μm),and the wettability was change with the over of time.X-ray photoelectron spectroscopy analysis showed that the oxide layer did not affect the polymer layer or loaded ***,the drugs lose their stability in a phosphate-buffered saline solution after 6.5 h of exposure,and its decrease was greater than 7%(HPLC analysis).The stability,drug release and concentration of the drug loaded into the material were precisely analyzed by high-performance liquid *** results correlated with the degradation of the polymer in which the addition of drugs caused the percent of degraded polymer to be between 35.5%and 49.4%after 1 h of material immersion,depending on the mass of the loaded drug and various biological responses that were ***,all of the coatings were cytocompatible with MG-63 osteoblast-like *** drug concentrations released from the coatings were sufficient to inhibit adhesion of reference and clinical bacterial strains(***).The coatings with amoxicillin showed the best results in the bacterial inhibition zone,whereas coatings with cefazolin inhibited adhesion of the above bacteria on the surface.

关键词： Titanium alloy poly(adipic anhydride) Antibacterial coatings cytocompatible Dental implants

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