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The Target of Benzimidazole Carbamate Against cysticerci cellulosae

Agricultural Sciences in China 2007年第8期6卷 1009-1017页

作者： LI Qing-zhang HAO Yan-hong GAO Xue-jun GAO Wen-xue ZHAO Bing College of Biological Science Northeast Agricultural University Harbin 150030 P.R.China

To study the target of benzimidazole carbamate drugs against cysticerci cellulosae and give a theoretical basis for type evolution and new drug design, the changes of key enzyme activities and metabolite contents in the pathway of energy metabolism in C. cellulosae in vitro and in vivo were tested with albendazole and oxfendazole, respectively. Both albendazole and oxfendazole inhibited the pathways of anaerobic glycolysis, partial inversed tricarboxylic acid cycle of Taenia Solium oncosphere, immature and mature cysticerci in vitro, and immature and mature cysticerci in vivo to a certain degree, and enhanced fat decomposing, amino acid decomposing, xanthine decomposing metabolism, and on the other hand, the absorption of glucose was hindered; furthermore, both albendazole and oxfendazole inhibited the activities of the fumaric reductase （FR） complex noncompetently in vitro. Benzimidazole carbamate drugs could inhibit the activities of FR complex noncompetently and hinder the absorption of glucose.

关键词： albendazole oxfendazole cysticerci cellulosae target energy metabolism

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Effects of Three Drugs on Membrane Metabolism Against cysticerci cellulosae in vitro

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Journal of Northeast Agricultural University(English Edition) 2009年第3期16卷 32-36页

作者： HAO Yanhong LI Qingzhang GAO Xuejun LIU Yongjie GAO Wenxue College of Veterinary Medicine Northeast Agricultural University Harbin 150030 China

To investigate the effects and mechanisms of the benzimidazole carbamate and benmidine drugs on cysticerci cellulosae and choose effective drugs on cysticerci cellulosae, the membrane metabolism of cysticerci cellulosae in vitro was tested after three kinds of drugs which were used respectively. The indexes included the contents of lipids, the contents of SA and the changes of the membrane fluidity. The results showed that oxfendazole could inhibit the membrane metabolism of immature and mature cysticerci cellulosae in vitro, and albendazole only inhibited the mature one, while thibendimidine neither acted on the immature nor mature one.

关键词： cysticerci cellulosae culture in vitro benzimidazole carbamate benmidine membrane metabolism

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