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A New Steroidal Glycoside from Roots of cynanchum auriculatum

Chinese Herbal Medicines 2010年第1期2卷 62-64页

作者： YIN Min,FENG Xu,CHEN Yu,WANG Ming,XIA Bing,DONG Yun-fa Institute of Botany,Jiangsu Province and Chinese Academy of Sciences,Jiangsu Center for Research & Development of Medicinal Plants,Nanjing 210014,China Institute of Botany Jiangsu Province and Chinese Academy of Sciences Jiangsu Center for Research & Development of Medicinal Plants Nanjing 210014 China

Objective To study the chemical constituents of cynanchum *** Two steroidal glycosides were purified by column chromatography and their structures were elucidated by spectroscopic *** and Conclusion Compound 1 is a ne... 详细信息

关键词： Baishouwu cynanchum auriculatum royle ex wight kidjoranin-3-O-β-D-cymaropyranoside steroidal glycoside

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Chemical constituents from endophytic fungus Plectosphaerella cucumerina YCTA2Z1 of cynanchum auriculatum

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Chinese Herbal Medicines 2018年第1期10卷 95-98页

作者： Xiao-Jie Gu Ke Ren Nan Yao Song Yan Jian-Fei Zhao Xing-Ying Jiang Qi Lian Department of Biotechnology School of Environmental and Chemical EngineeringDalianJiaotong UniversityDalian 116028China Department of Orthopaedics Zhongda HospitalSoutheast Universitynanjing 210009China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine NanjingUniversity of Chinese Medicinenanjing 210028China Laboratory of Translational Medicine Jiangsu Province Academy of Traditional Chinese Medicinenanjing 210028China

Objective： To study the chemical constituents from the Et OAc extract of endophytic fungal Plectosphaerella cucumerina YCTA2 ***： The chemical constituents were isolated and purified by silica gel column,Sephadex LH-20,and reverse-phase C-18 column chromatography as well as ***： Thirteen compounds were isolated from the EtOAc extract of the fungal strain YCTA2 *** chemical structures were elucidated according to the spectral *** were identified as caudatin（1）,baishouwubenzophenone（2）,cynandione B（3）,asterbatanoside A（4）,p-hydroxyphenethyl-O-β-D-glycoside（5）,caffeic acid（6）,ferulic acid（7）,2,5-dihydroxyacetophenone（8）,protocatechuic acid（9）,vanillic acid（10）,stearic acid（11）,azelaic acid（12）,and succinic acid（13）.Conclusions： It is the first chemical study on endophytic fungi from cynanchum auriculatum and all the compounds are obtained from the species,the genus,as well as the family Plectosphaerellaceae for the first time.

关键词： chemical constituents cynanchum auriculatum royle ex wight Endophytic fungi PleetosphaereUa cucumerina YCTA2Z1

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Metabolite Profiles of Caudatin-2,6-dideoxy-3-O-methyl-β-d-cymaropyranoside in Zebrafish by Ultraperformance Liquid Chromatography Quadrupole Time-of-flight Mass Spectrometry

Metabolite Profiles of Caudatin-2,6-dideoxy-3-O-methyl-β-d-...

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2019中国中西医结合学会临床药理与毒理专业委员会第三届学术研讨会

作者： Yongfang Ding Li Cui Yingjie Wei Luan Shu Yunru Peng Jiangsu Province Academy of Traditional Chinese Medicine

Objective: The root of cynanchum auriculatum royle ex wight(Asclepiadaceae), a well-known traditional Chinese medicine named ‘‘baishouwu’’, was reported to exhibit various biological activities. Caudatin-2, 6-dideoxy-3-O-methyl-β-d-cymaropyranoside(CDMC), a C-21 steroidal glycoside isolated from baishouwu, has been proved to possess antitumor activities in our previous studies. However, the routes and metabolites of CDMC in vivo remained largely unknown. In this study, the zebrafish model organism was used to clarify the metabolism of CDMC in vivo. Methods: The ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry(UPLC/Q-TOF-MS) technique combined with MetabolynxTM software was applied to identify the metabolites of CDMC in zebrafish after exposure for 24 h. Results: Ten metabolites of CDMC were found or tentatively identified based on MS and MS/MS data. The results suggested that hydroxylation, hydrogenation, dehydrogenation, demethylation, dehydroxylation and deglycosylation were the main metabolic processes of CDMC in zebrafish. Conclusion: Our study certified that the zebrafish model can wonderfully imitate the current models in explaining metabolic pathways of steroid compounds with the advantages of lower cost, far less amount of compounds needed, easy operation and high performance.

关键词： zebrafish caudatin-2,6-dideoxy-3-O-methyl-β-d-cymaropyranoside cynanchum auriculatum royle ex wight metabolite UPLC/Q-TOF-MS

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