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Food Science and Human Wellness 2017年第2期6卷 60-69页

作者： S.Jamuna Sakeena Sadullah M.S. R.Ashokkumar Gokul Shanmuganathan Senguttuvan Sivan Mozhi Niranjali Devaraj S. Department of Biochemistry University of MadrasGuindy CampusChennai 600025India Department of Biotechnology Prist UniversityPuducherryIndia

cymbopogon citratus(lemon grass)is commonly used in traditional folk *** essential oil extracted from *** has been reported as a potential anti-oxidant and anti-inflammatory *** study has been designed to explore the protective effect of ***(lemon grass)against modified LDL(OxLDL and H2O2 LDL)induced cytotoxicity in Peripheral Blood Mononuclear Cells(PBMC).The essential oil extracted from ***(EOC)was subjected to FT-IR spectroscopic analysis for the identification of functional *** vitro antioxidant assays were carried out to assess the electron donating capability of EOC as compared with a known standard L-ascorbic *** cytoprotective effects of EOC were determined in PBMC induced with modified *** obtained from FT-IR analysis showed the presence of functional groups in EOC such as H-bonded,O-H stretching,N-H stretching,aldehyde-C-H stretching,aldehyde/ketone-C=O stretching,-C=C-stretching,-CH_(3) bending,-C-H in plane *** has greater antioxidant property when compared with the standard L-ascorbic *** at all test concentrations demonstrated free radical scavenging activity and cytoprotective effect when challenged against modified LDL in *** above results show EOC as a promising antioxidant and cytoprotective agent.

关键词： cymbopogon citratus Antioxidants Cytoprotective PBMC Modified LDL

Phytochemical profiling and anticancer potential of cymbopogon citratus extract

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Asian Pacific Journal of Tropical Biomedicine 2024年第10期14卷 448-460页

作者： Bader O.Almutairi Mikhlid H.Almutairi Badr A.Al-Dahmash Saad Alkahtani Saud Alarifi Ahmed Rady Department of Zoology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Objective:To evaluate the anticancer potential of cymbopogon citratus ***:GC-MS analysis was used to identify phytocomponents in the methanolic extract of cymbopogon citratus.A fractionation method was employed to isolate and assess the bioactivity of different fractions and their cytotoxic activities against cancer cell lines HCT116,LoVo,Caco-2,and HT-29 were investigated.A dual staining method with acridine orange and ethidium bromide was used to assess the effect of the extract on cell ***,the expression levels of Bax and TP53 were quantified using real-time PCR in Caco-2 cells treated with the ethyl acetate fraction of cymbopogon citratus extract.A protein array was employed to profile key pro-and anti-apoptotic proteins in Caco-2 ***,molecular docking studies were conducted to investigate the interactions between key compounds of cymbopogon citratus extract and specific apoptosis-related protein domains(PDB IDs:7wql and 4bkx).Results:A significant growth inhibition was observed in Caco-2 cells treated with cymbopogon citratus *** the seven fractions of the plant extract,the ethyl acetate fraction showed the highest cytotoxicity against Caco-2 cells with an IC50 value of(6.16±0.01)μg/*** immunofluorescence assay showed that the ethyl acetate fraction could induce apoptosis of Caco-2 ***,the fraction upregulated the gene expressions of Bax and TP53 in a dose-dependent *** docking analysis demonstrated the interaction of five compounds isolated from the ethyl acetate fraction with key proteins in Caco-2 cells,indicating their anticancer ***:cymbopogon citratus extract shows anticancer activity against Caco-2 cells by inducing *** may be a promising candidate for the treatment of colon cancer,which needs further investigation.

关键词： cymbopogon citratus Anticancer Caco-2 cell Apoptosis Colon cancer

Phytoconstituents and diuretic activity of cymbopogon citratus leaf infusions in humans

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Journal of Coastal Life Medicine 2014年第9期 704-713页

作者： Christopher Ekpenyong Nyebuk Daniel Ernest Akpan Department of Physiology College of Health SciencesUniversity of UyoUyoAkwa Ibom StateNigeria

Objective:To assess the diuretic activity of infusions prepared from cymbopogon citratus(***)leaves in healthy ***:One hundred and five subjects(55 men and 50 women)aged 18 to 35 years were randomly assigned to groups set to orally receive infusions prepared from 2,4,or 8 g of *** leaf powder,once daily for 30 *** volume,frequency of urination,urine specific gravity,and plasma and urinary levels of electrolytes were assessed 1 day before(baseline),and at 10 and 30 d after initiation of *** diuretic indices were compared between experimental and baseline ***:Subjects treated with infusions prepared from *** leaf powder which tested positive for saponins,tannins,flavaniods,phenols,anthraquinones,alkaloids,and deoxy-sugar exhibited a significant increase in indices of diuresis including urine volume,urination frequency,diuretic action,natriuretic and saliuretic indices and renal fractional excretion of electrolytes and metabolic acidosis.A non-significant change in urine specific gravity was observed in all *** showed a non-significant increase at Day 10,but decreased significantly(P<0.05)at Day *** and aldosterone secretion indices decreased at Day 10,whereas carbonic anhydrase index increased significantly(P<0.05)at both Days 10 and ***:These results indicate a loop active diuretic action of *** infusion.

关键词： cymbopogon citratus Phytochemistry Diuretic activity Human

Incorporation of Essential Oils from cymbopogon citratus and Ceasalpinia Decapitala Leaves, Citrus Lemon and Citrus Sinensis Peels into HPC （HydroxyPropyl Cellulose） Films and Assessment of Their Antibacterial Activity

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Journal of Chemistry and Chemical Engineering 2013年第5期7卷 420-430页

作者： Theoneste Muhizi Stephane Grelier Veronique Coma Department of Chemistry National University of Rwanda Butare 117 Rwanda Laboratory of Chemistry and Organic Polymers (LCPO) University of Bordeaux 1 Pessac F-33600 France CNRS LCPO Pessac F-33600 France

In this study, essential oils from cymbopogon citratus and Ceasalpinia decapitala leaves, Citrus lemon and Citrus sinens＆ peels, were extracted, chemically characterized and evaluated on both Gram positive and Gram negative bacteria, Salmonella Typhimurium, Escherichia coli, Listeria innocua, Staphylococcus aureus, Klebsiella pneumonia and Streptococcus pyogenes. Essential oil of C. citratus was found to be rich in geranial （33.0%） and neral （49.7%）, that from C. decapitala in 13-pinene （8.4%）, ct-pinene （25.5%）, 13-ocymene （31.6%）, 15-phellandrene （8.4%）, caryophyllene （7.5%） and geranial （5.9%）. The essential oil from C. lemon and C. sinensis where mainly composed by limonene with percentages of 77.5% and 83.3% respectively, and 13-phellandrene with percentages of 8.1% and 10.8% for the essential oil of C. lemon and C. sinensis, respectively. The antibacterial activity assessment realized on different microorganisms contaminating food showed that essential oil from C. citratus was shah more effective against all tested bacteria while that from C. sinensis was the less active essential oil. The incorporation of essential oils in HPC （hydroxy-propyl cellulose） films showed that those essential oils, especially essential oils from C. citratus, maintained their antibacterial activities against targeted microorganisms and therefore can be applied in food packing.

关键词： Essential oils cymbopogon citratus Ceasalpinia decapitala Citrus lemon Citrus sinensis Essential oils-HPC films antibacterial activity.

Inventory and Management of Fungi Associated with Banana Plant through the Use of Allium ampeloprasum and cymbopogon citratus Extracts

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Journal of Agricultural Chemistry and Environment 2023年第2期12卷 51-64页

作者： Agyingi Lucy Ambang Keuete Kamdoum Elie Maah Romanus Nyamjua Department of Plant Biology Faculty of Science University of Dschang Dschang Cameroon Department of Plant Science Faculty of Science University of Buea Buea Cameroon

Despite the nutritional, economic and medicinal values of banana plant, independent of the region and production system is confronted with some diseases such as the fungi disease. These fungal diseases are responsible for the low yields. The objective of this study was to improve the sanitary state of banana plant. To achieve this objective, fungi associated with banana leaves were isolated on Potato Dextrose Agar (PDA) culture medium and their identification was done on the basis of morphological and microscopic characteristics using reference documents. Antifungal activity of Allium ampeloprasum and cymbopogon citratus extracts were evaluated in vitro on agar medium on the development of Pseudocercospora fijiensis, P. musicola and Pestalopsis sp. The results showed that banana plant harbours a diversity of fungal species, the most frequent being P. fijiensis (51.58%), Pestalopsis sp. (15.47%) and P. musicola (12.03%). Aqueous extracts of C. citratus at the concentration of 15 mg/ml, inhibited 100% of the radial growth of P. fijiensis and Pestalopsis sp with a fungitoxic activity. Similarly, ethanolic extract A. ampeloprasum inhibited at 100% the radial growth of Pestalopsis sp. This antifungal activity was fungistatic. These results suggest that the aqueous and ethanol extracts of the tested plants could be used as alternatives to chemical products in the fight against banana diseases especially Sigatoka. Hence further studies need to be undertaken to isolate the active compounds from these extracts with fungicidal potential.

关键词： Banana Fungi cymbopogon citratus Allium ampeloprasum Plant Extracts

Endophytic Colletotrichum from tropical grasses with a new species C. endophytica

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Fungal Diversity 2013年第4期61卷 107-115页

作者： Dimuthu S.Manamgoda Dhanushka Udayanga Lei Cai Ekachai Chukeatirote Kevin D.Hyde State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand

t Endophytic fungi are a diverse and important group of *** investigated the occurrence of Colletotrichum species as endophytes in two common tropical grass species,Pennisetum purpureum(dwarf napier)and cymbopogon citratus(lemon grass)in *** phylogenetic analysis of ITS,partial sequences of actin(ACT),calmodulin(CAL)and glyceraldehydes-3-phosphate dehydrogenase(GAPDH)gene regions and morphology were used to characterize the *** is the first report of an association as endophytes of Colletotrichum fructicola,*** and *** with Pennisetum purpureum,and *** and *** with cymbopogon *** endophytica *** with Pennisetum purpureum,is introduced based on multi-locus phylogenetic analysis with descriptions and *** potential hyperdiversity of the endophytic Colletotrichum species associated with tropical grasses is discussed with an emphasis on future research.

关键词： Phylogeny Poaceae Taxonomy Pennisetum purpureum cymbopogon citratus

Changes in blood pressure indices in normotensive adults after the consumption of lemongrass tea

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Journal of Coastal Life Medicine 2016年第10期4卷 802-808页

作者： Christopher Ekpenyong Eme Osim Department of Physiology Faculty of Basic Medical SciencesUniversity of UyoUyoAkwa Ibom StateNigeria Department of Physiology Faculty of Basic Medical SciencesUniversity of CalabarCalabarCross River StateNigeria

Objective:To accurately evaluate the effect of lemongrasses tea(LGT)on blood pressure(BP)indices in normal ***:A total of 105 participants were sub-divided into 3 groups with 35 in each group and they were administered with LGT prepared from 2,4 or 8 g of the lemongrass leaf powder(LP)for 30 days,*** were evaluated for various BP indices and other clinical and biochemical parameters at days 0,10 and 30 after the administration of LGT using standard ***:At day 10,systolic blood pressure and diastolic blood pressure(DBP)were lower than baseline *** mean arterial pressure was slightly reduced,while pulse pressure and heart rate(HR)significantly increased in subjects administered with LGT prepared from 4 or 8 g of the *** day 30,systolic blood pressure and DBP remained decreased in participants administered with LGT prepared from 4 g of the *** normalized in participants administered with LGT prepared from 4 g of the *** mean arterial pressure and HR decreased further in participants administered with LGT prepared from 8 g of the LP,but HR normalized in subjects treated with LGT prepared from 4 g of the *** pressure almost returned to baseline ***:Ingestion of LGT may be associated with decreased BP indices in normotensive humans due to its varied bioactive constituents and their activities.

关键词： cymbopogon citratus Phytoconstituents Hemodynamic Biochemical Effects Human