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Open Journal of Obstetrics and Gynecology 2024年第10期14卷 1556-1560页

作者： Koffi Soh Victor Adjoby Cassou Roland Effoh N’drin Denis Kouakou-Kouraogo Ramata Akobé Privat Loba Okoin Paul José Houphouet-Mwandji Blanche Carine Department of Obstetrics and Gynecology Teaching Hospital of Angr Abidjan Cte dIvoire Faculty of Medicine University Felix-Houphouet-Boigny Abidjan Cte dIvoire

cyclopia is a rare congenital brain malformation frequently associated with facial anomalies. It is characterized by the presence of a single eye with varying degrees of doubling of the intrinsic ocular structures located in the middle of the face. It is the most severe facial expression of holoprosencephaly. Its aetiology is still poorly understood, but several factors could play a role in its occurrence, including certain viruses contracted during pregnancy. Obstetrical ultrasound has made antenatal diagnosis and the search for associated malformations possible. This diagnosis must be made antenatally because the prognosis is poor, hence the decision to terminate the pregnancy. We report a case of cyclopia associated with ambiguity of the external genitalia, discovered intraoperatively in a patient with poor prenatal follow-up, in whom a coronavirus infection (COVID-19) had been diagnosed in early pregnancy.

关键词： cyclopia Holoprosencephaly Congenital Malformation COVID-19

Holoprosencephaly with cyclopia and Proboscis in a Female Namibian Baby: A Case Report

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Case Reports in Clinical Medicine 2022年第6期11卷 221-226页

作者： Charles Lukanga Kimera Deus Mbeseni Linda Ndesipandula Lukolo Department of Maternal & Child Health Obstetrics & Gynaecology School of Medicine University of Namibia Windhoek Namibia Department of Obstetrics & Gynaecology Ministry of Health and Social Services Windhoek Namibia Department of Community and Family Medicine School of medicine University of Namibia Windhoek Namibia

We present a case of Holoprosencephaly (HPE) with cyclopia and proboscis that was delivered in Katutura Intermediate Hospital, Namibia. The mother was a 24-year-old, G2P1 with no known comorbid conditions and no history of illicit or over-the-counter drug use. Her first pregnancy was uneventful and resulted in delivery of a normal baby. She had not attended antenatal clinic by the time of her presentation with the index pregnancy and the abnormality was picked up from the booking sonar. She went into spontaneous preterm labour and delivery before the planned date for admission for termination of pregnancy and physical examination of the baby confirmed the diagnosis of Holoprosencephaly with cyclopia. The pictures presented in this article were taken after obtaining parental consent.

关键词： Abnormality Congenital cyclopia Holoprosencephaly Proboscis

A Rare Case of Holoprosencephalus with cyclopia

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Open Journal of Obstetrics and Gynecology 2020年第8期10卷 976-980页

作者： Aliou Diouf Ousmane Thiam Cheikh C. T. Sarr Djibril B. Sow Mamour Gueye Mame D. Ndiaye Magatte Mbaye Regional Hospital Center of Saint-Louis Saint-Louis Senegal Gynecological and Obstetric Clinic EPS Aristide Le Dantec Dakar Senegal Gaston Berger University Saint-Louis Senegal

cyclopia is a rare genetic defect. It is the most severe form of alobar holoprosencephaly, characterized by the fusion of the two orbits and is linked to the lack of development of the frontal bud falling within the framework of ectroprosopia. Case presentation: This is a case report of Gravida 3 Para 3, 32 years old and without a history of abortion, with a history of normal vaginal birth which occurs during labor latency with active movements of the fetus present and cardiac activity on auscultation with pinard stethoscope. The uterine height was 32 cm with well palpated fetal poles. Ultrasound examination confirms the presence of normal cardiac activity with a poorly responsive fetus. After labor management, she gave birth 3 hours after admission to the maternity ward of a living newborn male weighing 2800 g with an Apgar score of 4/10 at the first minute and 2/10 at the fifth minute. He died 10 minutes later at the maternity hospital of the Saint-Louis regional hospital center, in northern Senegal. Conclusion: Holoprosencephaly is certainly rare but remains the most common structural congenital anomaly of the brain with a complex and multifactorial pathogenesis. Early perinatal diagnosis and determination of severity are important to inform parents of the possibilities of a future life. The voluntary termination of pregnancy is an option but remains prohibited in the country to this day for these indications.

关键词： Holoprosencephalus Fetus cyclopia Saint-Louis

Plant Enzymes, Root Exudates, Cluster Roots and Mycorrhizal Symbiosis are the Drivers of P Nutrition in Native Legumes Growing in P Deficient Soil of the Cape Fynbos in South Africa

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Journal of Agricultural Science and Technology(A) 2013年第5期3卷 331-340页

作者： Sipho Thulane Maseko Felix Dapare Dakora Department of Crop Sciences Faculty of Science Tshwane University of Technology Pretoria 0001 South Africa Chemistry Department Faculty of Science Tshwane University of Technology Pretoria 0001 South Africa

The Cape fynbos is characterised by highly leached, sandy, acidic soils with very low nutrient concentrations. Plant-available P levels range from 0.4 μg P g-1 to 3.7 μg P g-I soil, and 1-2 mg N gl soil. Despite these low nutrient concentrations, the fynbos is home to 9,030 vascular plant species with 68.7% endemicity. How native plant species survive such low levels of available P is intriguing, and indeed the subject of this review. In the fynbos soils, P is easily precipitated with cations such as Fe and Al, forming AI-P and Fe-P in acidic soils, or Ca-P in neutral-to-alkaline soils. The mechanisms for promoting P availability and enhancing P nutrition include the development of mycorrhizal symbiosis （with 80%-90% of higher plants, e.g., cyclopia, Aspalathus, Psoralea and Leucadendron etc.） which exhibits 3-5 times much greater P acquisition than non-mycorrhizal roots. Formation of cluster roots by the Leguminosae （Fabaceae） and their exudation of Kreb cycle intermediates （organic acids） for solubilizing P, secretion of root exudate compounds （organic acids, phenolics, amino acids, etc.） that mobilize P. The synthesis and release of acid and alkaline phosphatase enzyme that catalyze the cleavage of mineral P from organic phosphate esters in acidic and alkaline soils, and the development of deep tap roots as well as massive secondary roots within the uppermost 15 cm of soil for capturing water and nutrients. Some fynbos legumes employ all these adaptive mechanisms for enhancing P nutrition and plant growth. Aspalathus and cyclopia species typically form mycorrhizal and rhizobial symbiosis for improving P and N nutrition, produce cluster roots and acid phosphatases for increasing P supply, and release root exudates that enhance P solubilisation and uptake.

关键词： Cape fynbos cyclopia Aspalathus phosphorus mycorrhiza phosphatases.