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Effect of backing films on the transdermal delivery of cyclobenzaprine patch

Asian Journal of Pharmaceutical Sciences 2016年第6期11卷 780-783页

作者： Siji Lv Peng Quan Xiaochang Liu Liang Fang Department of Pharmaceutical Sciences Shenyang Pharmaceutical University

The aim of this study was to investigate the effect of backing films on transdermal delivery of cyclobenzaprine patch. Different backing films were chosen to prepare the cyclobenzaprine transdermal patch. The cumulative amount of cyclobenzaprine released from different patches was evaluated in vitro. To investigate the interaction between cyclobenzaprine and backing films, the partitioning experiments and attenuated total reflectance Fourier transform infrared(ATR-FTIR) spectroscopy were performed. The cumulative amount of cyclobenzaprine released from the patch with Cotran? 9700 as backing film was less than that of other patches with different backing films. Furthermore, the cumulative amount of cyclobenzaprine released from the patch with Cotran? 9700 as backing film decreased significantly after 7 d storage at room condition. The partitioning experiments indicated a strong adsorption of cyclobenzaprine onto the Cotran? 9700, which could explain the decrease of cumulative amount of cyclobenzaprine released from the patch with Cotran? 9700 as backing film. According to the ATR-FTIR results, there was no interaction between Cotran? 9700 and cyclobenzaprine. The effect of backing films on the release behavior of cyclobenzaprine transdermal patch was attributed to the adsorption of cyclobenzaprine onto the Cotran? 9700.

关键词： Transdermal patch Backing film Release cyclobenzaprine Partitioning experiment

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高压液相色谱法测定cyclobenzaprine片剂

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国际药学研究杂志 1983年第5期 320-321页

作者：李昭暄

cyclobenzaprine盐酸盐及其片剂是新版美国药典收载品种,测定方法缺少专属性,不能反映产品的稳定性。本文介绍使用高压液相测定其片剂的方法。仪器:具有254nm固定波长检出器的Altex 322型高压液相层析仪;进样采用Water710A型自动进样装... 详细信息

cyclobenzaprine盐酸盐及其片剂是新版美国药典收载品种,测定方法缺少专属性,不能反映产品的稳定性。本文介绍使用高压液相测定其片剂的方法。仪器:具有254nm固定波长检出器的Altex 322型高压液相层析仪;进样采用Water710A型自动进样装置,可定量注样20μl。图谱记录与结果计算采用HP3385A型积分仪。试剂:pH3,0.6%磷酸二氢钾缓冲液;内标采用盐酸萘唑啉的甲醇液mg/ml;标准液中内含cyclobenzaprine盐酸盐与盐酸萘唑啉分别为0.01mg/ml与0.05mg/ml。实验条件:流动相乙腈-0.6%磷酸盐缓冲液(pH3)(75:25);流速1.5ml/min。使用Zorbax C-8硅烷化硅胶柱(25×0.46cm内径),用毕次日,层析柱依次用75%乙腈水溶液和甲醇冲

关键词：片剂剂型 cyclobenzaprine 盐酸盐

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Rapid and sensitive analysis of cyclobenzaprine by LCeMS/MS:Application to a pharmacokinetic study of cyclobenzaprine in dog

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Asian Journal of Pharmaceutical Sciences 2014年第2期9卷 117-122页

作者： Wenhong Yu Xiaojing Yang Wenwen Sui Haiyan Xu Xinyi Luan Xiangjun Wang Yi Jin Bo Yuan Shenyang Pharmaceutical University No.103Wenhua RoadShenyang 110016China

A rapid and sensitive liquid chromatographyetandem mass spectrometry method was developed and validated for the quantification of cyclobenzaprine in dog *** extracted with organic solvent,post-treatment samples were separated on an Agela C18 column interfaced with a triple quadrupole tandem mass spectrometer in positive electrospray ionization *** reaction monitoring was performed using the transitions of m/z 276.2/216.1 and m/z 325.1/109.0 to quantify cyclobenzaprine and escitalopram(internal standard),*** mobile phase consisted of acetonitrile:5 mM ammonium acetate:formic acid(90:10:0.01,v/v/v)at a flow rate of 0.3 ml/*** total analysis time was 2.4 *** method was linear over the concentration range of 0.0200e10.0 ng/*** intra-and inter-day precision was within 12.8%in terms of relative standard deviation(RSD%)and the accuracy within 5.6%in terms of relative *** method was successfully applied in a pharmacokinetic study of extended-release cyclobenzaprine in dogs.

关键词： cyclobenzaprine LCeMS/MS Pharmacokinetic Plasma

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