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Anti-leishmanial,immunomodulatory and anti-oxidative activity of quercetin against cutaneous leishmaniasis caused by Leishmania major

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Asian Pacific Journal of Tropical Biomedicine 2023年第1期13卷 26-34页

作者： Ahmad Oryan Effat Bemani Somayeh Bahrami Department of Pathology School of Veterinary MedicineShiraz UniversityShirazIran Department of Parasitology Faculty of Veterinary MedicineShahid Chamran University of AhvazAhvazIran

Objective:To evaluate the in vitro and in vivo efficacy of quercetin and its immunomodulatory and anti-oxidative activity against Leishmania major(***).Methods:*** promastigotes and amastigotes were incubated with different concentrations of quercetin to estimate EC_(50).For in vivo study,the base of tails of mice was infected with *** developing ulcers in the inoculation site,mice were treated with 50 mg/kg quercetin orally for 28 consecutive *** wound-healing potential of quercetin was evaluated by histopathological analysis of tissue sections stained by hematoxylin and eosin as well as Masson's *** addition,the levels of tumor necrosis factor-α,interleukin-6,malondialdehyde,and adiponectin,the ferric reducing ability of plasma,as well as superoxide dismutase and glutathione peroxidase activities were ***:The EC_(50)values of quercetin against *** promastigotes and intracellular amastigotes were 0.27 and 0.85μM,*** analysis showed that fewer inflammatory cells,more fibroblasts,and more collagen deposition were observed in tissue sections of quercetin-treated *** addition,treatment with quercetin markedly increased glutathione peroxidase activity,the ferric reducing ability of plasma and adiponectin levels while decreasing malondialdehyde,interleukin-6,and tumor necrosis factor-α***:Quercetin shows anti-leishmanial activity,immunomodulatory,anti-oxidative,and anti-inflammatory ***,it may be further explored as an effective drug in treating leishmaniasis.

关键词： Leishmania major cutaneous leishmaniosis Wound healing Quercetin Immunomodulator

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