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Behçet Disease with Generalized Polymorphous cutaneous lesions:A Case Report

International Journal of Dermatology and Venereology 2022年第3期5卷 175-177页

作者： Li-Wei Wang Ling-Ling Luo Wei Zhang Xue-Si Zeng Pan-Gen Cui Department of Dermatology Department of Pathology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China.

Introduction:Behçet disease is a chronic multisystem vasculitis disease,however generalized polymorphous cutaneous lesions are ***,we reported a case of Behçet disease with multiple parts of the body and complex lesions,which may lead to misjudging in clinical *** report:A 69-year-old man presented with a seven-year history of recurrent generalized polymorphous mucocutaneous lesions(erythematous papules,nodules,ulcers,and necrosis)over his entire body,and the lesions had been painful for the past three *** on the past medical history,clinical presentation,histological examination excluded other diseases,and the 2014-amended International Criteria for Behget disease,the patient had a score of 6 points and was diagnosed as Behçet ***:The common clinical feature in patients with Behçet syndrome is the presence of recurrent and usually painful mucocutaneous *** clinical manifestations of this disorder are more variable among different patients.A diagnosis of generalized polymorphous cutaneous lesions should remain on the list of differential diagnosis of Behçet disease after excluding other ***:The mucocutaneous lesions of Behçet disease are often preceded by other manifestations,and timely diagnosis may benefit early treatment and prognosis.

关键词： Behçet disease cutaneous lesions generalized lesions poloymorphous

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CD34-Negative B-Lymphoblastic Leukemia/Lymphoma Presenting as Cutenous lesions at Infancy: A Case Report

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Journal of Biosciences and Medicines 2022年第4期10卷 20-25页

作者： Teresa Lotodo Festus Njuguna Samson Kiprono Gilbert Olbara Nicholas Kigen Moi University Eldoret Kenya Moi Teaching and Referral Hospital Eldoret Kenya AMPATH Reference Laboratories Eldoret Kenya

Acute lymphoblastic leukemia/lymphoma is a highly aggressive neoplasm of precursor lymphoid (blast) cells. There are 2 main subtypes based on lymphoid lineage;B lymphoblastic leukemia/lymphoma (B-ALL/LBL) and T lymphoblastic leukemia/lymphoma (T-ALL/LBL). B-ALL/LBL commonly presents with fever, fatigue, bone or joint pain, bleeding or anorexia (signs of bone marrow infiltration), lymphadenopathy, hepatosplenomegaly, involvement of skin, soft tissue and testes, with a predilection for the central nervous system. Immature cell markers, such as CD34 and TdT, can help to differentiate lymphoblasts from Burkitt lymphoma which, is considered a mature high-grade B cell lymphoma that mimics lymphoblastic lymphoma/leukemia. Unfavorable prognostic factors include: infancy and adult age of diagnosis, high white blood cell count, slow response to initial therapy, central nervous system involvement at the time of diagnosis and Minimal residual disease after therapy. We present a case report of a 4 months old infant seen at a Tertiary Hospital with a rare presentation of CD34 Negative B-lymphoblastic leukemia/lymphoma presenting as cutaneous lesions in infancy.

关键词： Lymphoblastic Leukemia Flow Cytometry CD34 Negative cutaneous lesions Infancy

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