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Bexarotene combined with lapatinib for the treatment of cushing’s disease:evidence based on drug repositioning and experimental confirmation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 988-990页

作者： Haoying Yu Shuyue Ren Jingrong Wang Tingting Lv Lan Sun Guanhua Du Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical College1 Xian Nong Tan Street100050 BeijingChina Beijing Key Laboratory of Drug Targets Identification and Drug Screening 100050 BeijingChina The State Key Laboratory of Bioactive Substance and Function of Natural Medicines 1 Xian Nong Tan Street100050 BeijingChina

Dear Editor,cushing’s disease(CD)is a rare disease manifested as cushing’s syndrome caused by adrenocorticotropic hormone(ACTH)consistently over-secreted by adrenocorticotropic adenomas,followed by stimulation of the adrenal gland to secrete considerable cortisol,triggering metabolic dysfunction,and leading to death from ***,pituitary adrenocorticotropic adenoma-directed drugs can only inhibit ACTH secretion or hamper tumour growth,which limits their clinical ***,Nur77(also known as NR4A1 and NGFI-Ba,a kind of nuclear receptor),an important positive transcription regulator of pro-opiomelanocortin(POMC),the precursor of ACTH,has been regarded as a promising CD target.1 Hence,it would be promising to identify a combination treatment that targets Nur77 and another CD target to cover hormone normalisation in the short term and tumour suppression or even elimination in the long term.

关键词： cushing drugs treatment

Transsphenoidal hypophysectomy and its effects on endocrinological status and serum chemistry parameters in dogs with cushing's disease

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畜牧与兽医 2012年第S2期44卷 9-11页

作者： Yasushi Hara Division of Veterinary Surgery School of Veterinary MedicineNippon Veterinary and Life Science University

cushing’s disease is a common endocrinopathy in dogs that is caused by an adrenocorticotropic hormone(ACTH)secreting corticotroph *** dogs with cushing’s disease have been treated by mitotane or trilostane in small animal clinical medicine[1,2,15-17].In humans,however,the first choice f treatment for cushing’s disease is transsphenoidal hypophysectomy(TSS)[3,4,6].In human clinical medicine,it has been suggested that excessive suppression of cortisol production using these drugs for the patients with cushing’s disease might delete the negative feedback effect of cortisol to the hypotahalamus and corticotrophs,and result in promoting the growth of ACTH secreting corticotroph adenoma,

关键词： cushing adenoma suppression delete recurrence promoting choice canine cholesterol routine

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cushing Syndrome Revealing an Adrenocortical Carcinoma

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Open Journal of Pediatrics 2018年第2期8卷 87-93页

作者： Bintou Sanogo Senkaye-Lagom Aimée Kissou Zakari Nikiema Makoura Barro Djingri Lankouandé Boubacar Nacro Department of Pediatrics University Hospital Center Souro Sanou (CHUSS) Bobo-Dioulasso Burkina Faso Higher Institute of Health Sciences Nazi Boni University (UNB) Bobo-Dioulasso Burkina Faso Medical Imaging Service Bobo-Dioulasso Burkina Faso Department of Internal Medicine Bobo-Dioulasso Burkina Faso

Adrenocortical carcinoma is a malignant tumor of the adrenal gland, very rare in pediatric pathology. Authors presented a pediatric case of adrenocortical carcinoma which showed neurology symptoms at 1st visit and cushing syndrome secondarily. The patient received a ketoconazole-based treatment. The outcome was fatal before the surgical excision of the tumor, because of delayed diagnosis. Early diagnosis and multidisciplinary management of adrenocortical carcinoma could improve the prognosis in children.

关键词： cushing Syndrome Adrenocortical Carcinoma Child

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cushing 综合征眼部表现一例

中华眼科杂志 1989年第1期25卷 57-58页

作者：王方张惠蓉北京医科大学第三医院眼科

cushing综合征,又名皮质醇增多症。虽内科和眼科书上对此病均有描述,但因其眼部表现缺乏特异性,易为眼科医生忽视,造成误诊。本文一例曾在各地检查多次均未确诊,后来我院始证实,现报告如下:郭某,女,29岁,因左眼视力减退一年,右眼视

关键词：皮质醇增多症 cushing 综合征激素

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急性颅脑损伤颅内压正常时发生cushing反应初步探讨

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中风与神经疾病杂志 1990年第3期 185-186页

作者：胡水刘丽朱庭吉吉林省石岘造纸厂职工医院白求恩医科大学一院神经外科

cushing反应是颅内压增高的表现之一,即脉搏减慢,呼吸慢加深,血压增高等三联反应。本文就急性颅脑挫伤颅内压正常时发生cushing反应的机理做一初步探讨。典型病例例一、贾××、男、35岁,术后诊断:颅底骨、左颞骨骨折,左硬膜下积液。术... 详细信息

cushing反应是颅内压增高的表现之一,即脉搏减慢,呼吸慢加深,血压增高等三联反应。本文就急性颅脑挫伤颅内压正常时发生cushing反应的机理做一初步探讨。典型病例例一、贾××、男、35岁,术后诊断:颅底骨、左颞骨骨折,左硬膜下积液。术后第4心天率变缓至36次/分,呼吸13次/分,血压16～18/10.8～12KPa,血钾:5.2mmol/L,腰穿测初压1.47KPa,脑脊液,RBC:2272×10~6/L,WRC8×10~6/L。为防止阿斯症,阿托品化后心率在60次/分以上。反复腰穿放液,第七天,腰穿测初压1.57KPa,脑

关键词：急性颅脑损伤初步探讨颅内压 cushing 腰穿硬脑膜

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经口鼻蝶入路治疗cushing氏病

北京大学学报(医学版) 1989年第3期 238-237页

作者：王源王象昌北京医科大学第一医院神经外科

近一年来本科收治了5例cushing氏病患者,其中男性1例,女性4例。兹报告如下: 病例摘要病例1 女性,35岁,患者因高血压8年,多毛和体重增加2年,月经不规则4个月收入院。入院查体:一般情况尚可,血压180/120mmHg,向心肥胖,面色红、多血质,皮... 详细信息

近一年来本科收治了5例cushing氏病患者,其中男性1例,女性4例。兹报告如下: 病例摘要病例1 女性,35岁,患者因高血压8年,多毛和体重增加2年,月经不规则4个月收入院。入院查体:一般情况尚可,血压180/120mmHg,向心肥胖,面色红、多血质,皮肤菲薄,眉毛重,双眼球突出,下

关键词：经蝶入路面部多血质病理报告 cushing ACTH 肿瘤样座疮血皮质醇垂体功能低下满月脸低密度区

cushing综合征诊断与治疗中若干问题的探讨

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中国医师进修杂志 1993年第3期 15-17页

作者：尹桂凤李昌臣王秀菊大连医学院附属一院内科内分泌组大连医学院附属一院内科内分泌组 116011

我院自1972年至1988年共收治cushing综合征(以下简称CS)28例,其中25例经手术及/或病理证实为本病。本文结合这25例,就其诊断与治疗中的若干问题简要探讨如下。临床资料一、一般资料:25例中男6例,女19例,男女之比为1:3.16。年龄12～56岁... 详细信息

我院自1972年至1988年共收治cushing综合征(以下简称CS)28例,其中25例经手术及/或病理证实为本病。本文结合这25例,就其诊断与治疗中的若干问题简要探讨如下。临床资料一、一般资料:25例中男6例,女19例,男女之比为1:3.16。年龄12～56岁。小于20岁3例(占12%),20～40岁18例(72%),41～50岁3例(12%),50岁以上1例(4%)。病程最短3个月,最长4年。二、术式及病理结果:见表1 三、临床表现:见表2

关键词：经蝶手术垂体微腺瘤肾上腺次全切除术 cushing 血皮质醇综合征综合病症