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Therapeutic potential of curcumin and its nanoformulations for treating oral cancer

World Journal of Methodology 2023年第3期13卷 29-45页

作者： Diptasree Mukherjee Arunkumar Krishnan Department of Biochemistry All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Medicine Apex Institute of Medical ScienceKolkata 700075West BengalIndia Department of Medicine Section of Gastroenterology and Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

The global incidence of oral cancer has steadily increased in recent years and is associated with high morbidity and *** cancer is the most common cancer in the head and neck region,and is predominantly of epithelial origin(*** cell carcinoma).Oral cancer treatment modalities mainly include surgery with or without radiotherapy and *** proven effective,chemotherapy has significant adverse effects with possibilities of tumor resistance to anticancer drugs and ***,there is an imperative need to identify suitable anticancer therapies that are highly precise with minimal side effects and to make oral cancer treatment effective and *** the available adjuvant therapies is curcumin,a plant polyphenol isolated from the rhizome of the turmeric plant Curcuma *** has been demonstrated to have antiinfectious,antioxidant,anti-inflammatory,and anticarcinogenic *** has poor bioavailability,which has been overcome by its various analogues and nanoformulations,such as nanoparticles,liposome complexes,micelles,and phospholipid *** have shown that the anticancer effects of curcumin are mediated by its action on multiple molecular targets,including activator protein 1,protein kinase B(Akt),nuclear factorκ-light-chainenhancer of activated B cells,mitogen-activated protein kinase,epidermal growth factor receptor(EGFR)expression,and EGFR downstream signaling *** targets play important roles in oral cancer pathogenesis,thereby making curcumin a promising adjuvant treatment *** review aims to summarize the different novel formulations of curcumin and their role in the treatment of oral cancer.

关键词： Oral cancer Oral squamous cell carcinoma Analogues curcumin Adjuvant therapy Nanocurcumin curcumin nanoformulations curcumin analogues

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