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Intensive follow-up vs conventional follow-up for patients with nonmetastatic colorectal cancer treated with curative intent:A metaanalysis

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2197-2211页

作者： Li-Li Cui Shi-Qi Cui Zhong Qu Zhen-Qing Ren Department of Operating Room Jiangsu Taizhou People’s HospitalTaizhou 225300Jiangsu ProvinceChina Department of Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020Zhejiang ProvinceChina Department of Endoscopy Center Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020Zhejiang ProvinceChina Department of Nursing Jiangsu Taizhou People’s HospitalTaizhou 225300Jiangsu ProvinceChina

BACKGROUND The frequency and content of follow-up strategies remain controversial for colorectal cancer(CRC),and scheduled follow-ups have limited *** To compare intensive and conventional follow-up strategies for the prognosis of non-metastatic CRC treated with curative intent using a *** PubMed,Embase,and the Cochrane Library databases were systematically searched for potentially eligible randomized controlled trials(RCTs)from inception until April *** Cochrane risk of bias was used to assess the methodological quality of the included *** hazard ratio,relative risk,and 95%confidence interval were used to calculate survival and categorical data,and pooled analyses were performed using the random-effects *** exploratory analyses were performed for sensitivity,subgroups,and publication *** Eighteen RCTs involving 8533 patients with CRC were selected for the final *** follow-up may be superior to conventional follow-up in improving overall survival,but this difference was not statistically ***,intensive follow-up was associated with an increased incidence of salvage surgery compared to conventional *** addition,there was no significant difference in the risk of recurrence between intensive and conventional follow-up strategies,whereas intensive follow-up was associated with a reduced risk of interval recurrence compared to conventional ***,the effects of intensive and conventional follow-up strategies differed when stratified by tumor location and follow-up *** Intensive follow-up may have a beneficial effect on the overall survival of patients with non-metastatic CRC treated with curative intent.

关键词： Intensive follow-up Conventional follow-up Colorectal cancer curative intent Meta-analysis

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Emerging curative-intent minimally-invasive therapies for hepatocellular carcinoma

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World Journal of Hepatology 2022年第5期14卷 885-895页

作者： Kylie E Zane Paul B Nagib Sajid Jalil Khalid Mumtaz Mina S Makary College of Medicine The Ohio State UniversityColumbusOH 43210United States Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Division of Vascular and Interventional Radiology Department of RadiologyThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

Hepatocellular carcinoma(HCC)is the most common cause of liver malignancy and the fourth leading cause of cancer deaths *** can be achieved for early stage HCC,which is defined as 3 or fewer lesions less than or equal to 3 cm in the setting of Child-Pugh A or B and an ECOG of *** outside of these criteria who can be down-staged with loco-regional therapies to resection or liver transplantation(LT)also achieve curative ***,surgical resection,LT,and ablation are considered curative therapies for early ***,results from recently conducted LEGACY study and DOSISPHERE trial demonstrate that transarterial radio-embolization has curative outcomes for early HCC,leading to its recent incorporation into the Barcelona clinic liver criteria guidelines for early *** review is based on current evidence for curativeintent loco-regional therapies including radioembolization for early-stage HCC.

关键词： Hepatocellular carcinoma Loco-regional therapy Radiation segmentectomy Transarterial radio-embolization Ablation Transarterial chemo-embolization curative intent

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