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Integrative pan-cancer analysis of cuproplasia-associated genes for the genomic and clinical characterization of 33 tumors

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Chinese Medical Journal 2023年第21期136卷 2621-2631页

作者： Xinyu Li Weining Ma Hui Liu Deming Wang Lixin Su Xitao Yang Department of Interventional Therapy Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 201999China Department of Neurosurgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 201999China Department of Pediatrics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Nephrology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200060China

Background:The molecular mechanisms driving tumorigenesis have continually been the focus of *** is defined as copper-dependent cell growth and proliferation,including its primary and secondary roles in tumor formation and proliferation through signaling *** this study,we analyzed the differences in the expression of cuproplasia-associated genes(CAGs)in pan-cancerous tissues and investigated their role in immune-regulation and tumor ***:Raw data from 11,057 cancer samples were acquired from multiple ***-cancer analysis was conducted to analyze the CAG expression,single-nucleotide variants,copy number variants,methylation signatures,and genomic signatures of micro RNA(miRNA)-messenger RNA(mRNA)*** Genomics of Drug Sensitivity in Cancer and the Cancer Therapeutics Response Portal databases were used to evaluate drug sensitivity and resistance against *** single-sample Gene Set Enrichment Analysis(ssGSEA)and Immune Cell Abundance Identifier database,immune cell infiltration was analyzed with the ssGSEA score as the ***:Aberrantly expressed CAGs were found in multiple *** frequency of single-nucleotide variations in CAGs ranged from 1%to 54%among different ***,the correlation between CAG expression in the tumor microenvironment and immune cell infiltration varied among different ***7A and ATP7B were negatively correlated with macrophages in 16 tumors including breast invasive carcinoma and esophageal carcinoma,while the converse was true for MT1A and *** addition,we established cuproplasia scores and demonstrated their strong correlation with patient prognosis,immunotherapy responsiveness,and disease progression(P<0.05).Finally,we identified potential candidate drugs by matching gene targets with existing ***:This study reports the genomic characterization and clinical features of CAGs in *** helps clarify the relationsh

关键词： cuproplasia Pan-cancer Gene Tumor

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