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Color-tunable Gd-Zn-Cu-ln-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging

Nano Research 2014年第11期7卷 1581-1591页

作者： Weisheng Guo Weitao Yang Yu Wang Xiaolian Sun Zhongyun Liu Bingbo Zhang Jin Chang Xiaoyuan Chen Institute of Nanobiotechnology School of Materials Science and Engineering Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials Tianjin 300072 China Laboratory of Molecular Imaging and Nanomedicine National Institute of 8iomedical Imaging and Bioengineering National Institutes of Health Bethesda MD 20892 USA Shanghai East Hospital The Institute for 8iomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 China Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging Department of Radiology Zhongda Hospital Medical School of Southeast University Nanjing 210009 China

Inorganic nanoparticles have been introduced into biological systems as useful probes for in vitro diagnosis and in vivo imaging, due to their relatively small size and exceptional physical and chemical properties. A new kind of color- tunable Gd-Zn-Cu-In-S/ZnS （GZCIS/ZnS） quantum dots （QDs） with stable crystal structure has been successfully synthesized and utilized for magnetic resonance （MR） and fluorescence dual modality imaging. This strategy allows successful fabrication of GZCIS/ZnS QDs by incorporating Gd into ZCIS/ZnS QDs to achieve great MR enhancement without compromising the fluorescence properties of the initial ZCIS/ZnS QDs. The as-prepared GZCIS/ZnS QDs show high T1 MR contrast as well as ＂color-tunable＂ photoluminescence （PL） in the range of 550-725 nm by adjusting the Zn/Cu feeding ratio with high PL quantum yield （QY）. The GZCIS/ZnS QDs were transferred into water via a bovine serum albumin （BSA） coating strategy. The resulting Cd-free GZCIS/ZnS QDs reveal negligible cytotoxicity on both HeLa and A549 cells. Both fluorescence and MR imaging studies were successfully performed in vitro and in vivo. The results demonstrated that GZCIS/ZnS QDs could be a dual-modal contrast agent to simultaneously produce strong MR contrast enhancement as well as fluorescence emission for in vivo imaging.

关键词： cuins2 quantum dot magnetic resonance imaging^photoluminescence rnultimodality imaging gadolinium doped

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