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Crystal structure of monkeypox H1 phosphatase,an antiviral drug target

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Protein & Cell 2023年第6期14卷 469-472页

作者： Wen Cui Haojun Huang Yinkai Duan Zhi Luo Haofeng Wang Tenan Zhang Henry C Nguyen Wei Shen Dan Su Xi Li Xiaoyun Ji Haitao Yang Wei Wang Institute of Life Sciences Chongqing Medical UniversityChongqing 400016China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu 610064China State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical SciencesSchool of Life SciencesNanjing UniversityNanjing 210023China Shanghai Clinical Research and Trial Center Shanghai 201210China Tianjin International Joint Academy of Biotechnology and Medicine Tianjin 300450China

Dear Editor,Since its appearance in May 2022,monkeypox has spread to>100 countries and afflicted tens of thousands of people.Individuals infected with monkeypox present a fever,an extensive characteristic rash,and usually swollen lymph nodes(Chatterjee et al.,2022).The number of confirmed cases worldwide continues to grow at a rapid rate,but the treatment to this highly infectious viral disease is still very limited.Identification of new targeted-therapies will be crucial to control of this emerging public health threat.

关键词： monkey Crystal

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332

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Protein & Cell 2022年第9期13卷 689-693页

作者： Yao Zhao Chao Fang Qi Zhang Ruxue Zhang Xiangbo Zhao Yinkai Duan Haofeng Wang Yan Zhu Lu Feng Jinyi Zhao Maolin Shao Xiuna Yang Leike Zhang Chao Peng Kailin Yang Dawei Ma Zihe Rao Haitao Yang Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Bioorganic&Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China National Facility for Protein Science in Shanghai Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Taussig Cancer Center Cleveland ClinicClevelandOH 44195USA Laboratory of Structural Biology School of Life Sciences and School of MedicineTsinghua UniversityBeijing 100091China State Key Laboratory of Medicinal Chemical Biology Frontiers Science Center for Cell ResponseCollege of Life SciencesNankai Universityand Tianjin Key Laboratory of Protein SciencesTianjin 300071China

Dear Editor,Since December 2019,the pandemic of coronavirus disease 2019(COVID-19)has taken a heavy toll on global health,creating an urgent need to develop effective strategies for prevention and treatment.The etiological agent,known as severe acute respiratory syndrome coronavirus 2(SARSCoV-2),has infected nearly 229.2 million people worldwide with more than 4.7 million deaths as of September 15,2021.Older age and preexisting health conditions are associated with worse clinical prognosis including higher mortality rates(Zhou et al.,2020).The global race to combat this pandemic has led to rapid deployment of numerous effective vaccines against SARS-CoV-2(Tregoning et al.,2021).However,the emergence of viral variants,including the Delta variant(B.1.617.2),compromised vaccine effectiveness with resurgence of SARS-CoV-2 infection among highly vaccinated population(Keehner et al.,2021).Therefore,development of therapeutics against the more conserved viral targets would be essential to contain the spread of COVID-19 and reduce mortality.

关键词： mortality prevention Crystal

Synthesis,Crystal Structure,Spectroscopy and Hirshfeld Analysis of 4,6-Diamino-2-cyclopropylaminopyrimidine-5-carbonitrile with Different Solvents:N,N-dimethylformamide,Methanol and Water

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Chinese Journal of Structural Chemistry 2022年第3期41卷 277-286,I0015页

作者：葛书旺孙柏旺 School of Chemistry and Chemical Engineering Southeast UniversityNanjing 210096China

Three new solvates of 4,6-diamino-2-cyclopropylamino-5-pyrimidine carbonitrile(DCL):Crystal 1(DCL with N,N-dimethylformamide(DMF)),Crystal 2(DCL with methanol)and Crystal 3(DCL with water)were synthesized and characterized by single-Crystal X-ray diffraction,thermal behaviour,Hirshfeld surface and powder X-ray powder diffraction(PXRD).1H and ^(13)C NMR spectra confirm solvent molecules existing in the Crystal lattice.Crystal 1 forms a 1:1 DCL:DMF Crystal;Crystal 2 gives a 1:0.5 DCL:methanol Crystal and Crystal 3 gets a 1:1.5 DCL:H_(2)O Crystal.The three Crystals are all primarily stabilized by a strong N–H×××N hydrogen bonding interaction between DCL and the solvents.The structures are stabilized by H×××H,N–H×××O,N–H×××N and O–H×××O intermolecular interactions.When Crystal 2 is dried at 150℃,the new polymorph with no solvate is obtained.

关键词： dicyclanil Crystal spectroscopy Hirshfeld surfaces

Flexible Organic Single Crystal with Elastic Bending and Plastic Twisting Capabilities

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Chinese Journal of Structural Chemistry 2022年第12期41卷 4-6页

作者： Jiang Peng Wanjun Zhao Jing Zhang Chuchu Han Junhui Jia Tingting Feng Jiawen Sun Key Laboratory of Magnetic Molecules and Magnetic Information Material Ministry of EducationCollege of Chemistry and Material ScienceShanxi Normal UniversityTaiyuan 030000China

INTRODUCTION Organic single Crystals have found wide-spread applications in smart materials,[1]optical waveguide devices,[2]photonic applications,[3]lasers,[4]OLED materials,and so on.

关键词： waveguide Crystal OLED

Structural design and characterization of a new chalcone molecular derivative Crystal DMNC with high second-order nonlinear coefficient

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Chinese Journal of Structural Chemistry 2023年第3期42卷 7-10页

作者： Jinkang Ma Siyuan Hu Xueting Mu Rui Chen Kun Meng Bing Teng Lifeng Cao Degao Zhong College of Physics Qingdao UniversityQingdao266071China National Demonstration Center for Experiment Applied Physics Education(Qingdao University) Qingdao266071China College of Physics University-Industry Joint Center for Ocean Observation and Broadband CommunicationQingdao UniversityQingdao266071China Weihai Innovation Research Institute of Qingdao University Weihai264200China Quenda Terahertz Technologies Ltd.600 Jiushui E Rd.Qingdao266102China

1.Text In recent years,new organic second-order nonlinear optical materials have been widely used in optical imaging,data storage,information processing and communication,etc.[1].Therefore,designing and growing crysta... 详细信息

关键词： nonlinear derivative Crystal

Spin-preserving chiral photonic Crystal mirror

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Light(Science & Applications) 2020年第1期9卷 1787-1798页

作者： Behrooz Semnani Jeremy Flannery Rubayet Al Maruf Michal Bajcsy Institute for Quantum Computing(IQC) University of WaterlooWaterloo N2L3G1 ONCanada Department of Electrical&Computer Engineering University of WaterlooWaterloo N2L3G1 ONCanada Department of Physics and Astronomy University of WaterlooWaterloo N2L3G1 ONCanada

Chirality refers to a geometric phenomenon in which objects are not superimposable on their mirror image.Structures made of nanoscale chiral elements can exhibit chiroptical effects,such as dichroism for left-and right-handed circularly polarized light,which makes these structures highly suitable for applications ranging from quantum information processing and quantum optics to circular dichroism spectroscopy and molecular recognition.At the same time,strong chiroptical effects have been challenging to achieve even in synthetic optical media,and chiroptical effects for light with normal incidence have been speculated to be prohibited in thin,lossless quasi-two-dimensional structures.Here,we report an experimental realization of a giant chiroptical effect in a thin monolithic photonic Crystal mirror.Unlike conventional mirrors,our mirror selectively reflects only one spin state of light while preserving its handedness,with a near-unity level of circular dichroism.The operational principle of the photonic Crystal mirror relies on guided-mode resonance(GMR)with a simultaneous excitation of leaky transverse electric(TE-like)and transverse magnetic(TM-like)Bloch modes in the photonic Crystal slab.Such modes are not reliant on the suppression of radiative losses through long-range destructive interference,and even small areas of the photonic Crystal exhibit robust circular dichroism.Despite its simplicity,the mirror strongly outperforms earlier reported structures and,contrary to a prevailing notion,demonstrates that near-unity reflectivity contrast for opposite helicities is achievable in a quasi-two-dimensional structure.

关键词： mirror Crystal circular

Recent Progress on Monoelemental Nanomaterials with Unconventional Crystal Phases

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Accounts of Materials Research 2023年第4期4卷 359-372页

作者： Bo Chen Qinbai Yun Yiyao Ge Lujiang Li Hua Zhang Department of Chemistry City University of Hong KongHong KongChina School of Materials Science and Engineering Peking UniversityBeijing 100871China Department of Chemistry and Hong Kong Branch of National Precious Metals Material Engineering Research Center City University of Hong KongHong KongChina Shenzhen Research Institute City University of Hong KongShenzhen 518057China

As an important parameter of Crystalline materials,the Crystal phase describes the periodic atomic arrangement in their structures.For some monoelemental materials,e.g.,carbon and phosphorus,they can exist in more than one Crystal phase.The different Crystal phases of monoelemental materials result in different physicochemical properties and functions.Therefore,engineering the Crystal phase of monoelemental materials gives an effective strategy to modulate their properties and functions.Conventionally,the Crystal phase of monoelemental materials can be altered under some harsh conditions,e.g.,high temperature and high pressure.Recently,with the rapid development of nanotechnology,various monoelemental materials with unconventional Crystal phases have been well developed on the nanoscale.For example,our group has successfully achieved the synthesis of Au nanomaterials with unconventional hexagonal close-packed(hcp)2H and 4H phases by wetchemical methods,which exhibit distinct optical properties as well as outstanding electrocatalytic performance when compared to those with a thermodynamically stable facecentered cubic(fcc)phase.In this Account,we give a comprehensive overview of the recent development of monoelemental nanomaterials with unconventional Crystal phases and their Crystal-phase-dependent properties and applications.We first introduce the typical strategies for the synthesis of monoelemental nanomaterials with unconventional Crystal phases.By using a wet-chemical reduction method,template-assisted method,and thermal annealing method,monoelemental nanomaterials with unconventional Crystal phases can be directly prepared.Besides,unconventional-phase monoelemental nanomaterials can also be obtained via the phase transformation from materials with conventional Crystal phases under specific conditions.In addition,some other methods have also been reported for preparing monoelemental nanomaterials with unconventional Crystal phases,such as controlled Crystallization of amorphous structure,the chemical vapor t

关键词： Crystal preparing arrangement

Dirac-vortex topological photonic Crystal fibre

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Light(Science & Applications) 2020年第1期9卷 24-30页

作者： Hao Lin Ling Lu Institute of Physics Chinese Academy of Sciences/Beijing National Laboratory for Condensed Matter PhysicsBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan523808 GuangdongChina

The success of photonic Crystal fibres relies largely on the endless variety of two-dimensional photonic Crystals in the cross-section.Here,we propose a topological bandgap fibre whose bandgaps along in-plane directions are opened by generalised Kekulémodulation of a Dirac lattice with a vortex phase.Then,the existence of mid-gap defect modes is guaranteed to guide light at the core of this Dirac-vortex fibre,where the number of guiding modes equals the winding number of the spatial vortex.The single-vortex design provides a single-polarisation single-mode for a bandwidth as large as one octave.

关键词： fibre vortex Crystal

Holographic fabrication of octagon graded photonic superCrystal and potential applications in topological photonics

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Frontiers of Optoelectronics 2020年第1期13卷 12-17页

作者： Oliver SALE Safaa HASSAN Noah HURLEY Khadijah ALNASSER Usha PHILIPOSE Hualiang ZHANG Yuankun LIN Department of Physics University of North TexasDentonTX 76203USA ECE Department University of Massachusetts LowellLowellMA 01854USA Department of Electrical Engineering University of North TexasDentonTX 76203USA

Novel optical properties in graded photonic super-Crystals can be further explored if new types of graded photonic super-Crystals are fabricated.In this paper,we report holographic fabrication of graded photonic super-Crystal with eight graded lattice clusters surrounding the central non-gradient lattices through pixel-by-pixel phase engineering in a spatial light modulator.The prospect of applications of octagon graded photonic super-Crystal in topological photonics is discussed through photonic band gap engineering and coupled ring resonators.

关键词： 2D photonic Crystal graded photonic superCrystal holographic fabrication photonic band structure