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Clinical Assessment of a Mesotherapy Formulation for skin Rejuvenation in Healthy Volunteers

Journal of Cosmetics, Dermatological sciences and Applications 2017年第4期7卷 291-305页

作者： Anne Grand-Vincent sylvie Boisnic Catherine salomon Pascal Prinderre Philippe Piccerelle Aesthetic Medecine Center Paris French scientific Research and Assessment Group in Dermatology and Cosmetology (GREDECO) Paris French Filorga Laboratories Paris French Pharmaceutical Bioengineering Department Mediterranean Institute of Biodiversity and Marine Ecology Marseille French

Mesotherapy is a mildly invasive procedure involving several subcutaneous drug injections, which are performed simultaneously. The concept is to inject a very small amount of active compounds (hyaluronic acid, vitamins, antioxidants, enzymes, humectants, …) and the aim is to stimulate the biosynthetic capacity of fibroblasts, increase collagen and elastin production and to give active essential molecules for a fibroblasts environment. Numerous studies suggest that the mesotherapy procedure improves skin hydration and mechanical properties;however, some results have not been statistically significant. In this study, we investigated an antiaging treatment as a complementary approach to a non-surgical rejuvenating procedure after 5 sessions of mesotherapy. Our main objective was to assess the improvement of face, neck and neckline skin quality, after intradermal microinjections of NCTF 135HA®. This mixture, manufactured by FILORGA Laboratories, includes a non-cross-linked hyaluronic acid, vitamins, antioxidants, mineral salts and enzymes. A statistically significant decrease in the depth of crow’s-feet wrinkles (43.3%) and in pore size (58.5%) was observed. Also, dermatological scores showed a significant decrease, and data suggest that skin tone was improved with a brighter tone. The injected mixture could then have an action on the skin pigmentation process with a photoprotective effect. Evolution of Dermis density was also investigated and an increase of dermal density and thickness were highlighted, showing an improvement of skin firmness with significant increases of dermis thickness (20%) and dermis density (24%), indicating a neocollagen activity.

关键词： Mesotherapy skin Rejuvenation Multi-Component solution crow’s-feet Wrinkles Pore size Dermis Density Dermis Thickness

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