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Cross-immune tolerance:conception and its potential significance on transplantation tolerance

Cellular & Molecular Immunology 2010年第1期7卷 20-25页

作者： Yong Zhao Xianchang Li Transplantation Biology Research Division State Key Laboratory of Biomembrane and Membrane BiotechnologyInstitute of ZoologyChinese Academy of SciencesBeijingChina Harvard Medical School Transplant Research CenterBeth Israel Deaconess Medical CenterBostonMAUSA

The diversity of alloreactive T cells in graft rejection and the presence of extensive crossreactivity among alloreactive T cells indicate thatthe induction oftransplantation tolerancemay fundamentally alter the size ofhost T-cell repertoireinvolved in protective immunity and immune surveillance,especially those that are crossreactive to conventional *** herein highlight the crossreactive nature of alloreactive T cells and the potential risks of altered T-cell repertoire associated with the induction of transplantation *** possibility that T-cell tolerance to one set of antigens results in their tolerance to other unrelated antigens due to T-cell crossreactivity and/or heterogeneity is defined as‘cross-immune tolerance’.The definition and significance of this concept were discussed in details.

关键词： crossreactivity T-cell repertoire tolerance transplantation

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Cross-reactivity of anti-H pylori antibodies with membrane antigens of human erythrocytes

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World Journal of Gastroenterology 2007年第27期13卷 3742-3746页

作者： Feng-Hua Guo Xiao-Mei Yan Chun-Xiang Fan Fei Zhao Yuan Hu Di Xiao Xun Zeng Mao-Jun Zhang Li-Hua He Fan-Ling Meng Jian-Zhong Zhang National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention PO Box 5 Changping Beijing 102206 China

AIM： To investigate whether anti-H pylori antibodies have cross-reaction with antigens of erythrocyte membrane. METHODS： Blood samples were collected from 14 volunteers （8 positive and 6 negative for Hpylori detected by ^13C-urea breath test） of the general population. Erythrocyte membrane proteins of the subjects were examined by Western blot using anti-H pylori serum. The proteins related to the positive bands were identified by mass spectrum analysis. RESULTS： Anti-Hpylori antibodies had cross-reaction with the proteins of about 50 kDa of erythrocyte membranes in all samples independent of H pylori infection. One protein in the positive band was identified as Chain S, the crystal structure of the cytoplasmic domain of human erythrocyte Band-3 protein. CONCLUSION： Anti-HpyloH antibodies cross-react with some antigens of human erythrocyte membrane, which may provide a clue for the relationship between Hpylori infection and vascular disorders.

关键词： H pylori Antibodies Erythrocyte crossreactivity

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