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Charge-reversible crosslinked nanoparticle for pro-apoptotic peptide delivery and synergistic photodynamic cancer therapy

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Nano Research 2023年第12期16卷 13267-13282页

作者： Haijing Qu Han Chen Wei Cheng Yuqing Pan Zhiran Duan Yanjun Wang Xing-Jie Liang Xiangdong Xue Shanghai Frontiers Science Center of Drug Target Identification and Delivery School of PharmacyShanghai Jiao Tong UniversityShanghai 200240China National Key Laboratory of Innovative Immunotherapy Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200011China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

Although anti-cancer nanotherapeutics have made breakthroughs,many remain clinically unsatisfactory due to limited delivery efficiency and complicated biological ***,we prepared charge-reversible crosslinked nanoparticles(PDC NPs)by supramolecular self-assembly of pro-apoptotic peptides and photosensitizers,followed by crosslinking the self-assemblies with polyethylene glycol to impart tumor microenvironment responsiveness and *** resultant PDC NPs have a high drug loading of 68.3%,substantially exceeding that of 10%–15%in conventional drug delivery *** NPs can overcome the delivery hurdles to significantly improve the tumor accumulation and endocytosis of payloads by surface charge reversal and responsive crosslinking ***-apoptotic peptides target the mitochondrial membranes and block the respiratory effect to reduce local oxygen consumption,which extensively augments oxygen-dependent photodynamic therapy(PDT).The photosensitizers around mitochondria increased along with the peptides,allowing PDT to work with pro-apoptotic peptides synergistically to induce tumor cell death by mitochondria-dependent apoptotic *** strategy would provide a valuable reference for improving the delivery efficiency of hydrophilic peptides and developing mitochondrial-targeting cancer therapies.

关键词： charge-reversible nanoparticle crosslinked nanoparticle peptide delivery photodynamic therapy synergistic cancer treatment

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A personal journey on using polymerization in aqueous dispersed media to synthesize polymers with branched structures

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Chinese Chemical Letters 2019年第12期30卷 1996-2002页

作者： Haifeng Gao Department of Chemistry and Biochemistry University of Notre Dame

This short review is dedicated to celebrate *** Fu’s 80 th birthday by discussing several of my accomplished projects over the past twenty years,which all applied radical polymerization in aqueous dispersed media for producing polymers with branched *** projects include the use of microemulsion polymerization for syntheses of fluorescent nanoparticles,hairy nanoparticles and hyperbranched polymers;the use of miniemulsion polymerization for synthesis of star polymers and light-emitting nanoparticles;the use of seeded emulsion polymerization for synthesis of hairy nanoparticles and hyperstar polymers;and the use of precipitation polymerization for synthesis of hollow polymer *** of these projects demonstrates intriguing features of polymerization in biphasic dispersed media via either conventional radical polymerization or controlled radical polymerization to effectively regulate the branched structure of functional polymers.

关键词： Aqueous dispersed media Radical polymerization crosslinked nanoparticle Nanocapsule Hyperbranched polymer

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