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Seroepidemiologic study on convalescent sera from dengue fever patients in Jinghong,Yunnan

Virologica Sinica 2022年第1期37卷 19-29页

作者： Yingshuo Ma Man Li Lyu Xie Na Gao Dongying Fan Kaihao Feng Yao Yao Yong Zhou Ziyang Sheng Hongning Zhou Hui Chen Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Yunnan Institute of Parasitic Diseases Pu’er665000China People's Hospital of Xishuangbanna Dai Autonomous Prefecture Xishuangbanna666100China Xishuangbanna Mental Health Center Xishuangbanna666100China Yunnan Provincial Key Laboratory of Vector-Borne Diseases Control and Research and Yunnan Provincial Collaborative Innovation Center for Public Health and Disease Prevention and Control(YPCICPHDPC) Pu’er665000China Experimental Center for Basic Medical Teaching School of Basic Medical SciencesCapital Medical UniversityBeijing100069China

After dengue virus(DENV)infection,antibody-dependent enhancement(ADE)is easy to occur when the neutralizing antibody(NAb)gradually decreases to a sub-neutralizing *** this cohort surveillance,we utilized sera samples collected from dengue fever patients at different convalescent phases in Jinghong City,to investigate the dynamic change rule of DENV-specific antibodies,and to analyze the risk of ADE caused by secondary infection with heterologous serotypes *** baseline serosurvey,191 four-year and 99 six-year sera samples during convalescence were collected in 2017 and 2019,*** positive rate of DENVspecific immunoglobulin G was 98.4%in 2017,which significantly decreased to 82.8%in *** geometric mean titer(GMT)of NAb decreased from 1:155.35 to 1:*** 290 overall samples,73 paired consecutive samples were used for follow-up *** four-year sera,the GMTs of NAb against DENV-3 and cross-reactive antibodies against DENV-1,DENV-2 and DENV-4 were 1:167.70,1:13.80,1:18.54 and 1:45.26,respectively,which decreased to 1:53.18,1:10.30,1:14.60 and 1:8.17 in six-year *** age-stratified analysis,due to the increasing number of ADE positive samples from 2017 to 2019 in 31–40 and 51–60 years groups,the risk of ADE in DENV-4 infection was positively associated with the extension of convalescent phase,and the odd ratio was higher than other *** the recovery period lengthened,the risk of secondary infection with DENV-1 and DENV-2 was *** results offer essential experimental data for risk prediction of severe dengue in hyper-endemic dengue areas,and provide crucial scientific insight for the development of effective dengue vaccines.

关键词： Dengue virus(DENV) Seroepidemiology Neutralizing antibody(NAb) cross-reactive antibody antibody dependent enhancement(ADE)

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