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Estimating glomerular filtration rate preoperatively for patients undergoing hepatectomy

World Journal of Gastroenterology 2009年第18期15卷 2252-2257页

作者： Yoshimi Iwasaki Tokihiko Sawada Shozo Mori Yukihiro Iso Masato Katoh Kyu Rokkaku Junji Kita Mitsugi Shimoda Keiichi Kubota Department of Gastroenterological Surgery Dokkyo Medical University880 KitakobayashiMibuTochigi321-0293Japan

AIM:To compare creatinine clearance(Ccr) with estimated glomerular filtration rate(eGFR) in preoperative renal function tests in patients undergoing ***:The records of 197 patients undergoing hepatectomy between August 2006 and August 2008 were studied,and preoperative Ccr,a three-variable equation for eGFR(eGFR3) and a five-variable equation for eGFR(eGFR5) were *** values were defined as Ccr creatinine(post Cr) level and postoperative rate of increase in the serum Cr level(post Cr rate) were ***:There were 37 patients(18.8%) with abnormal Ccr,31(15.7%) with abnormal eGFR3,and 40(20.3%) with abnormal *** there were no significant differences in the post Cr rate between patients with normal and abnormal Ccr,eGFR3 and eGFR5 values,the post Cr level was significantly higher in patients with eGFR3 and eGFR5 abnormality than in normal patients(P test in patients undergoing hepatectomy.

关键词： Estimated glomerular filtration rate creatinine clearance test Hepatectomy Renal functiontest

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eGFR is a reliable preoperative renal function parameter in patients with gastric cancer

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World Journal of Gastroenterology 2010年第19期16卷 2417-2420页

作者： Takayuki Kosuge Tokihiko Sawada Yoshimi Iwasaki Junji Kita Mitsugi Shimoda Nobumi Tagaya Keiichi Kubota Sec-ond Department of Surgery Dokkyo Medical University Kitako-bayashi 880 Mibu Shimotsuga Tochigi 321-0293 Japan

AIM: To evaluate the validity of the estimated glomerular filtration rate (eGFR) as a preoperative renal function parameter in patients with gastric cancer. METHODS: A retrospective study was conducted in 147 patients with gastric cancer. Preoperative creatinine clearance (Ccr), eGFR, and preand postoperative serum creatinine (sCr) data were examined. Preoperative Ccr and eGFR were then compared for their reliability in predicting postoperative renal dysfunction. RESULTS: Among 110 patients with normal preoperative Ccr values, 7 (6.3%) had abnormal postoperative sCr values, and among 112 patients with normal preoperative eGFR values, postoperative sCr was abnormal in 5 (4.5%) (P = 0.53). Among 37 patients with abnormal preoperative Ccr values, 30 (81.1%) had normal postoperative sCr values, and of 35 patients with abnormal preoperative eGFR values, postoperative sCr was normal in 25 (71.4%) (P = 0.34). PreoperativeCcr was signifi cantly correlated with eGFR (r = 0.514), and postoperative sCr was significantly correlated with preoperative Ccr (r = -0.334) and eGFR (r = -0.02). CONCLUSION: Preoperative eGFR is as effective as Ccr for predicting postoperative renal dysfunction. eGFR should therefore be used as an indicator of preoperative renal function in place of Ccr since it is a cheaper and easier to perform test.

关键词： Estimated glomerular filtration rate creatinine clearance test Gastric cancer

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