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A New Glucoside from Rhodiola fastigiata (crassulaceae)

Acta Botanica Sinica 2002年第2期44卷 224-226页

作者：杨辉梅双喜彭丽艳林中文孙汉董中国科学院昆明植物研究所植物化学开放实验室

A new glucoside, fastigitin A (1), namely 2-O-β-D-glucopyransyl-3-methyl-methyl pinalate, together with twelve known constituents (2-13), was isolated from the root of Rhodiola fastigiata (Hook. f. et Thoms.) S. H. Fu collected from Nujiang Lisu autonomous region, Yunnan, China. Their structures were identified by spectral (including 2D-NMR techniques) and chemical methods. Compounds 2 and 5-9 were obtained from this plant for the first time.

关键词： Rhodiola fastigiata crassulaceae glucoside fastigitin A

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Evaluation of the Anticonvulsant Activity of the Leaf Methanol Extract of Crassula arborescens （Mill.） Willd. （crassulaceae） in Mice

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Journal of Pharmacy and Pharmacology 2014年第7期2卷 393-403页

作者： George Jimboyeka Amabeoku Oluchi Nneka Mbamalu Tasneem Davids Samukelisiwe Fakude Anda Gqwaka Fiona Mbai Reighman Pieterse Aneesa Shaik Discipline of Pharmacology University of the Western Cape Cape Town 7535 Western Cape South Africa

Crassula arborescens （Mill.） Willd. subsp. Arborescens is widely used for the treatment of various ailments including diarrhoea, corns, epilepsy and as a purgative. However, no information exists in any literature to verify the acclaimed effectiveness of C. arborescens in the treatment of the various ailments. The study, therefore, intended to investigate the anticonvulsant activity of the leaf methanol extract of C. arborescens in mice. Acute toxicity study and phytochemical qualitative analysis of the plant extracts were also carried out. Chemically-induced convulsion methods were used to assess the anticonvulsant activity of C. arborescens. Standard methods were used for the acute toxicity study and phytochemical analysis of the chemical components of the plant extract. PTZ （pentylenetetrazole）, bicuculline, picrotoxin, NMDLA （N-methyl-DL-aspartic acid） or strychnine produced tonic convulsions in all the mice used. Leaf methanol extract of Crassula arborescens, muscimol, phenobarbitone or diazepam significantly antagonised PTZ, bicuculline or picrotoxin-induced convulsion. C. arborescens or LY233053 significantly antagonised NMDLA-induced tonic convulsion. C. arborescens or phenobarbitone significantly antagonised strychnine-elicited tonic convulsion. Phenytoin or DMSO （dimethylsulfoxide） did not significantly affect the tonic convulsion produced by PTZ, bicuculline, picrotoxin, NMDLA or strychnine. The LDso value obtained from intraperitoneal administration of C. arborescens was 781.6 mg/kg while that following oral administration of the plant extract was over 4,000 mg/kg. The phytochemical qualitative analysis done showed the presence of flavonoids, tannins, reducing sugar, saponins and triterpene steroids. The data obtained in the study show that the leaf methanol extract of Crassula arborescens has anticonvulsant activity which may be underpinned by GABAergic, glutaminergic and glycinergic mechanisms. The high LDso value obtained following the oral administra

关键词： Crassula arborescens crassulaceae anticonvulsant activity GABAergic glutamatergic and glycinergic mechanisms mice.

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Chemical constituents from Kalanchoe hybrida and their cytotoxicity

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Chinese Herbal Medicines 2018年第2期10卷 231-235页

作者： Ping-chung Kuo Hsin-yi Hung Yu-ren Liao Yu-yi Chan Tian-shung Wu School of Pharmacy College of Medicine National Cheng Kung University Department of Biotechnology Southern Taiwan University of Technology Department of Pharmacy College of Pharmacy and Health Care Tajen University

Objective：Kalanchoe hybrida（crassulaceae）is naturalized throughout all the island of Taiwan in *** preliminary bioassay-guided fractionation of the crude extract of *** exhibited that the chloroform and n-butanol fractions possessed potent cytotoxicity against MCF-7,NCI-H460,and SF-268 tumor cell lines at 50μg/m L ***,*** was selected as a target and the chemical constituents from the chloroform and n-butanol fractions of the crude extracts of *** were *** potential constituents were examined for their cytotoxicity against the tumor cell ***：A combination of conventional chromatographic techniques was performed on the crude extract of *** chemical structures of the purified constituents were identified on the basis of spectroscopic and spectrometric ***：The purification results had led to the characterization of totally 37 *** isolated compounds 1,2,and 4–12 were examined for their cytotoxicity in vitro,and bufadienolides 4–8 and flavonol glycoside 11 displayed significant cytotoxicity towards all the tested tumor cell lines among these tested ***：The results indicated that these principles should be responsible for the bioactivity of corresponding partial *** potential constituents could be further investigated to explore the new natural lead drugs.

关键词： bufadienolide crassulaceae cytotoxicity flavonol glycoside Kalanchoe hybrida(J. D. Hooker)Vilmorin

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Phytochelatins induction in the new hyperaccumulator Sedum alfredii Hance exposed to cadmium

Phytochelatins induction in the new hyperaccumulator Sedum a...

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2007中国植物生理学会全国学术会议

作者： Zhongchun Zhang Xiang Gao Baosheng Qiu~* (College of Life Sciences,Central China Normal University,Wuhan 430079,Hubei,P.R.China)

＜正＞Phytochelatins（PCs）are enzymatically synthesized peptides produced in some higher plants and fungi when exposed to heavy metals,such as cadmium,lead,zinc and so *** are rich in the-SH group and have the structure of（γ-Glu-Cys）n-Gly,where n is generally varied from two to *** are considered to detoxify heavy metals especially cadmium toxicity in *** can be chelated by PCs and the

关键词： Sedum alfredii crassulaceae Hyperaccumulator Phytochelatins Cadmium Lead Zinc

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Phytochelatins induction in the new hyperaccumulator Sedum alfredii Hance exposed to cadmium

Phytochelatins induction in the new hyperaccumulator Sedum a...

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湖北省植物生理学会第十五次学术研讨会

作者： Zhongchun Zhang Xiang Gao Baosheng Qiu College of Life Sciences,Central China Normal University,Wuhan 430079,Hubei,P.R.China

Phytochelatins (PCs) are enzymatically synthesized peptides produced in some higher plants and fungi when exposed to heavy metals,such as cadmium,lead,zinc and so *** are rich in the -SH group and have the structure o... 详细信息

关键词： Sedum alfredii crassulaceae Hyperaccurnulator Phytochelatins Cadmium Lead Zinc

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红景天野生变家植栽培技术

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人参研究 1990年第2期2卷 45-46页

作者：张铭运王素珍林宝录赵占英秦佳梅吉林人参研究所通化市园艺研究所

红景天(Rhodiola ***)又名,高山景天、库页红景天,是景天科 crassulaceae 多年生草本植物。该植物分布在欧洲、北美、亚洲西部和北部;在亚洲分布于日本、朝鲜、中国和苏联.在我国多分布在东北地区。

关键词：红景天根库页红景天栽培技术 crassulaceae 多年生草本 Rhodiola 亚洲西部山景天植物分布种子繁殖

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