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Physicochemical properties,antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids

Asian Pacific Journal of Tropical Biomedicine 2018年第4期8卷 201-206页

作者： Suresh S.Kumbar Kallappa M.Hosamani Arun K.Shettar Department of Studies in Chemistry Kamatak University P G Department of Studies in Biotechnology and Microbiology Karnatak University

Objective:To study physicochemical properties,antioxidant and anti-inflammatory activities of coumarin-carbonodithioate ***:The substituted 4-bromomethyl coumarins were synthesized in first step by the *** the reaction of substituted coumarins(a-e)with potassium O-ethyl/methyl carbonodithioate(1)by using absolute ethanol as solvent,afforded coumarin-carbonodithioate(1a-1j)derivatives under microwave irradiation and the conventional *** spectroscopic analysis was used for the characterization of coumarin *** title(1a-1j)compounds were confirmed by spectroscopic *** property was evaluated by using DPPH free radical-scavenging ability assay method and anti-inflammatory activity was evaluated by protein denaturation procedure using diclofenac sodium as a ***-silico toxicity was predicted with LD_(50)value and bioactivity score was also calculated for all the ***:All coumarin(1a-1j)compounds exhibited promisingin-vitro antioxidant and anti-inflammatory properties in comparison to standard *** tested compounds were used for evaluating their physicochemical properties as set by Lipinski *** was observed that the synthesized compounds followed rule of five,indicating more'drug-like'***:All the screened coumarin-carbonodithioates display promising in vitro antioxidant and antiinflammatory *** the physicochemical properties of coumarin derivatives,it is found that none of the compounds violate the Lipinski rule and they fall well in the range of rule of *** is concluded that the coumarin-carbonodithioate hybrids act with more'drug-like'nature.

关键词： Physicochemical properties coumarin-carbonodithioates In vitro antioxidant activity In vitro anti-inflammatory activity

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