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Sedative–hypnotic effect of YZG-330 and its effect on chloride influx in mouse brain cortical cells

Acta Pharmaceutica Sinica B 2013年第4期3卷 234-238页

作者： Lili Liu Shaobo Jia Jingwen Dong Ying Zhang Ruiming Xu Jianjun Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

This study was to examine the sedative–hypnotic effect of YZG-330 and its influence on Cl−influx in mouse cortical *** a sleep time-prolongation test in which mice were administered a threshold dosage of sodium pentobarbital(ip),YZG-330(0.125,0.5 and 2 mg/kg,po)prolonged the sleep time by 25%(P40.05),64%(Po0.01)and 506%(Po0.001),***,treatment with YZG-330 permitted mice that had woken up after the threshold dose of sodium pentobarbital(ip)to fall asleep again.A Cl−-sensitive fluorescent probe,N-(ethoxycarbonylmethyl)-methoxyquinolinium bromide(MQAE),was used to determine the effect of YZG-330 on Cl−***-330(0.3,0.6 and 1.5 mM)increased Cl−influx in mouse cortical cells in a concentration-dependent *** data suggest that YZG-330 has a hypnotic effect in mice,and the effect may be related to an increase in Cl−influx in cortical cells.

关键词： Sedative–hypnotic Sleep Cl−influx MQAE cortical cells

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Cell-specific pathways recruited for symbiotic nodulation in the Medicago truncatula legume

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Molecular Plant 2022年第12期15卷 1868-1888页

作者： Sergio Alan Cervantes-Pérez Sandra Thibivilliers Carole Laffont Andrew D.Farmer Florian Frugier Marc Libault Department of Agronomy and Horticulture Center for Plant Science InnovationUniversity of Nebraska-LincolnLincolnNE 68503USA Single Cell Genomics Core Facility Center for BiotechnologyUniversity of Nebraska-LincolnLincolnNE 68588USA Institute of Plant Sciences Paris-Saclay(IPS2) UniversitéParis-SaclayCNRSINRAEUniversitéParis-CitéUniversitéd’Evry91190 Gif-sur-YvetteFrance National Center for Genome Resources Santa FeNM 87505USA

Medicago truncatula is a model legume species that has been studied for decades to understand the symbiotic relationship between legumes and soil bacteria collectively named *** symbiosis called nodulation is initiated in roots with the infection of root hair cells by the bacteria,as well as the initiation of nodule primordia from root cortical,endodermal,and pericycle cells,leading to the development of a new root organ,the nodule,where bacteria fix and assimilate the atmospheric dinitrogen for the benefit of the ***,we report the isolation and use of the nuclei from mock and rhizobia-inoculated roots for the single nuclei RNA-seq(sNucRNA-seq)profiling to gain a deeper understanding of early responses to rhizobial infection in Medicago roots.A gene expression map of the Medicago root was generated,comprising 25 clusters,which were annotated as specific cell types using 119 Medicago marker genes and orthologs to Arabidopsis cell-type marker genes.A focus on root hair,cortex,endodermis,and pericycle cell types,showing the strongest differential regulation in response to a short-term(48 h)rhizobium inoculation,revealed not only known genes and functional pathways,validating the sNucRNA-seq approach,but also numerous novel genes and pathways,allowing a comprehensive analysis of early root symbiotic responses at a cell type-specific level.

关键词： Medicago root single-cell transcriptomic rhizobium nodule initiation root hair cells cortical cells

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A novel strategy for producing high-performance continuous regenerated fibers with wool-like structure

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SusMat 2022年第1期2卷 90-103页

作者： Guang Sheng Cao Ze Ping Zhang Min Zhi Rong Ming Qiu Zhang Materials Science Institute Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationGD HPPC LabSchool of ChemistrySun Yat-Sen UniversityGuangzhouP.R.China

We proposed a novel approach to prepare high-performance continuous regenerated keratin fibers with wool-like structure by using the cortical cells and linear keratin from wool waste as reinforcement and adhesive,*** spindle-shaped cortical cells were taken from wool waste based on the different responses of cortical cells and mesenchyme in wool to the treatments of H_(2)O_(2) oxidation and *** linear keratin was yielded through dissolving wool waste in the green solution consisting of starch derived dithiothreitol and protein denaturant sodium dodecyl *** recycled keratin fibers were produced by wet-spinning of the mixture solution comprising of cortical cells,linear keratin and toughener poly(ethylene glycol)diacrylate,and crosslinked by glutaraldehyde and 4,4′-methylenebis-(phenyl isocyanate).The cortical cells were aligned along the regenerated fibers axis and retained quite a fewα-helical crystals of the intermediate filaments,benefitting improvement of mechanical ***,the valuable chemical compositions and hierarchical microstructures of wool were largely *** mechanical properties,thermal stability,dyeing property,moisture absorption capability,and antistatic resistance resembled those of *** regenerated fibers contained 93.3 wt.%components of wool,and the amount of synthetic chemicals in the regenerated fibers was controlled to as low as 6.7 wt.%.

关键词： continuous regenerated fibers cortical cells keratin wet-spinning wool waste

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