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Effect of bivalirudin on myocardial microcirculation and adverse events after interventional therapy in older patients with acute coronary syndrome

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World Journal of Clinical Cases 2024年第22期12卷 4890-4896页

作者： Ya-Kun Du Li-Jun Cui Hong-Bo Gao Cardiovascular Department Hanzhong People’s HospitalHanzhong 723000Shaanxi ProvinceChina

BACKGROUND Bivalirudin,a direct thrombin inhibitor,is used in anticoagulation therapies as a substitute for heparin,especially during cardiovascular procedures such as percutaneous coronary *** To explore the effect of bivalirudin on myocardial microcirculation following an intervention and its influence on adverse cardiac events in elderly patients with acute coronary syndrome(ACS).METHODS In total,165 patients diagnosed with acute myocardial at our hospital between June 2020 and June 2022 were enrolled in this *** June 2020 to June 2022,elderly patients with ACS with complete data were selected and treated with interventional *** study cohort was randomly divided into a study group(n=80,administered bivalirudin)and a control group(n=85,administered unfractionated heparin).Over a 6-mo follow-up period,differences in emergency processing times,including coronary intervention,cardiac function indicators,occurrence of cardiovascular events,and recurrence rates,were *** Significant differences were observed between the study cohorts,with the observation group showing shorter emergency process times across all stages:Emergency classification;diagnostic testing;implementation of coronary intervention;and conclusion of emergency treatment(Pmyocardial reperfusion,and reduced incidence of bleeding complications and adverse cardiac events.

关键词： Bivalirudin Heparin Acute coronary syndrome corrected thrombolysis in myocardial infarction flow frame count thrombolysis in myocardial infarction myocardial perfusion classification

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