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Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization

引用

Bioactive Materials 2022年第8期7卷 416-429页

作者： Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan Jiexin Zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart CenterSino-Japanese Cooperation Platform for Translational Research in Heart FailureZhujiang HospitalSouthern Medical UniversityGuangzhou510280China Biomaterials Research Center School of Biomedical EngineeringSouthern Medical UniversityGuangzhou510515China Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangdong Provincial Key Laboratory of Medical BiomechanicsNational Key Discipline of Human AnatomySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China

Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell *** direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical *** reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial *** this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics *** results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the *** addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1α*** brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization.

关键词： Artificial stem cells Exosomes Myocardial infarction coronary collateralization

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