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Effects of different statins application methods on plaques in patients with coronary atherosclerosis

World Journal of Clinical Cases 2021年第4期9卷 812-821页

作者： Xia Wu Xiao-Bo Liu Ting Liu Wen Tian Yu-Jiao Sun Department of Geriatrics First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Radiology First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Discontinued application of statins may be related to adverse cardiovascular ***,it is unclear whether different statins administration methods have effects on coronary artery *** To evaluate the effects of different statins application methods on plaques in patients with coronary *** A total of 100 patients diagnosed with atherosclerotic plaque by coronary artery computed tomography were continuously selected and divided into three groups according to different statins administration methods(discontinued application group,n=32;intermittent application group,n=39;sustained application group,n=29).The effects of the different statins application methods on coronary atherosclerotic plaque were *** The volume change and rate of change of the most severe plaques were significantly reduced in the sustained application group(P≤0.001).The volume change of the most severe plaques correlated positively with low-density lipoprotein(LDL-C)levels only in the sustained application group(R=0.362,P=0.013).There were no changes in plaques or LDL-C levels in the intermittent and discontinued application *** Continuous application of statins is effective for controlling plaque progression,whereas discontinued or intermittent administration of statins is not conducive to controlling *** with continuous statins administration can a reduction in LDL-C levels result in plaque volume shrinkage.

关键词： coronary atherosclerotic plaque Statin coronary artery computed tomography Low-density lipoprotein plaque volume

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