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Network pharmacology combined with molecular docking revealed the potential targets of coridius chinensis in prostate cancer treatment

引用

World Journal of Clinical Cases 2024年第27期12卷 6094-6104页

作者： Mei Zhang Jing Ma Feng-Yin Zeng Xiao-Hui Hou School of Preclinical Medicine Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Prostate cancer(PCa)has high morbidity and mortality rates in elderly *** a history of thousands of years,traditional Chinese medicine derived from insects could be an important source for developing cancer-targeted drugs to prevent tumorigenesis,enhance therapeutic effects,and reduce the risk of recurrence and *** studies have shown that coridius chinensis(Cc)has anticancer *** To elucidate the mechanism of action of Cc against PCa via network pharma-cology and molecular *** Potential targets for Cc and PCa were predicted using ChemDraw 19.0 software,the PharmMapper database and the GeneCards ***,the STRING database was used to construct the protein–protein interaction *** Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment and molecular docking analyses were subsequently conducted to identify the key targets,active ingredients and pathways *** GO and KEGG analyses indicated that the PI3K-Akt signalling pathway was the critical pathway(P value<1.0×10-8).Multiple targeting ingredients that can affect multiple pathways in PCa have been identified in *** active compounds(asponguanosines A,asponguanine B,asponguanine C,aspong-pyrazine A,N-acetyldopamine,aspongadenine B and aspongpyrazine B)were selected for molecular docking with 9 potential targets,and the results revealed that aspongpyrazine A and asponguanosine A are the main components by which Cc affects PCa(affinity<-5 kcal/mol,hydrogen bonding),but more studies are *** We used network pharmacology to predict the bioactive components and important targets of Cc for the treatment of PCa,supporting the development of Cc as a natural anticancer agent.

关键词： coridius chinensis Molecular docking Network pharmacology Prostate cancer Traditional Chinese medicine

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