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Upconversion nanoparticles@AgBiS_(2) core-shell nanoparticles with cancer-cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers

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Bioactive Materials 2022年第11期7卷 71-80页

作者： Zhaoyou Chu Tian Tian Zhenchao Tao Juan Yang Benjin Chen Hao Chen Wanni Wang Peiqun Yin Xiaoping Xia Hua Wang Haisheng Qian School of Biomedical Engineering School of Basic Medical SciencesAnhui Provincial Institute of Translational MedicineAnhui Medical UniversityHefeiAnhui230032PR China Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefeiAnhui230032PR China Department of Radiation Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230031China Department of Obstetrics and Gynecology Children’s Hospital of Anhui Medical UniversityAnhui Provincial Children’s HospitalHefeiAnhui230051PR China

UCNPs@AgBiS_(2) core-shell nanoparticles that AgBiS_(2) coated on the surface of upconversion nanoparticles (UCNPs) was successfully prepared through an ion exchange reaction. The photothermal conversion efficiency of AgBiS_(2) can be improved from 14.7% to 45% due to the cross relaxation between Nd ions and AgBiS_(2). The doping concentration of Nd ions played a critical role in the production of reactive oxygen species (ROS) and enhanced the photothermal conversion efficiency. The NaYF4:Yb/Er/Nd@NaYF4:Nd nanoparticles endows strong upcon-version emissions when the doped concentration of Nd ions is 1% in the inner core, which excites the AgBiS_(2) shell to produce ROS for photodynamic therapy (PDT) of cancer cells. As a result, the as-prepared NaYF4:Yb/Er/ Nd@NaYF4:Nd@AgBiS_(2) core-shell nanoparticles showed combined photothermal/photodynamic therapy (PTT/ PDT) against malignant tumors. This work provides an alternative near-infrared light-active multimodal nano-structures for applications such as fighting against cancers.

关键词： Upconversion nanoparticles core-shell nanoparticles Photothermal conversion Facile synthesis Photodynamic therapy

Fabrication and Characterization of Sulfonate-containing Polystyrene/CaCO_(3) core-shell nanoparticles

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Chinese Journal of Chemistry 2014年第7期32卷 579-584页

作者： Yang Hu Jishuai Wang Guanzhi Cheng Jie Shen Chengyou Kan Department of Chemical Engineering Laboratory of Advanced Materials of Ministry of EducationTsinghua UniversityBeijing 100084China

Polystyrene(PSt)seed latex was first prepared via soap-free emulsion polymerization in the presence of a small amount of methacrylic acid using ammonium persulfate as initiator,and then seeded emulsion polymerization of sodium 4-styrenesulfonate(NaSS)and St was carried out to synthesize P(St-NaSS)core latex using 2,2'-azobisisobutyronitrile as initiator.After that,P(St-NaSS)/CaCO_(3) core-shell nanoparticles were fabricated by sequentially introducing Ca(OH)_(2) aqueous solution and CO_(2) gas into the core latex.The morphology of the core and core-shell nanoparticles was characterized by dynamic light scattering(DLS)and transmission electron microscopy(TEM),and the state of CaCO_(3) shell was confirmed with high-resolution scanning transmission electron microscope(HR-STEM)and selected area electron diffraction(SAED).Results showed that PNaSS chains were successfully grafted onto the PSt seed surface,and length of the PNaSS“hairs”could be modulated by adjusting NaSS amount.Sulfonic groups of the PNaSS hairs served as additives in the formation and stabilization of amorphous CaCO_(3)(ACC)and prevented ACC from sequent transformation into crystalline states.The amount of the anchored CaCO_(3) increased with the growth of PNaSS hair length,and reached 51 wt%(by thermalgravimetric analysis)under the optimal encapsulating temperature of 45℃.Moreover,the forming mechanism of P(St-NaSS)/CaCO_(3) coreshell nanoparticles was proposed.

关键词： core-shell nanoparticles sulfonate emulsion polymerization encapsulation amorphous calcium carbonate

Synthesis and Characterization of Dendrimer-Encapsulated Bimetallic core-shell PdPt nanoparticles

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Chinese Journal of Chemistry 2012年第3期30卷 541-546页

作者：李国平卢文婷罗运军夏敏柴春鹏王晓青 School of Chemistry and Chemical Engineering Central South UniversityChangshaHunan 410083China

Using a successive method, PAMAM dendrimer-encapsulated bimetallic PdPt nanoparticles have been successfully prepared with core-shell structures （Pd@Pt DENs）. Evidenced by UV-vis spectra, high resolution trans- mission electron microscopy, and X-ray energy dispersive spectroscopy （EDS）, the obtained Pd@Pt DENs are monodispersed and located inside the cavity of dendrimers, and they show a different structure from monometallic Pt or Pd and alloy PdPt DENs. The core-shell structure of Pd@Pt DENs is further confirmed by infrared measure- ments with carbon monoxide （IR-CO） probe. In order to prepare Pd@Pt DENs, a required Pd/Pt ratio of 1 ： 2 is de- termined for the Pt shell to cover the Pd core completely. Finally, a mechanism for the formation of Pd@Pt DENs is proposed.

关键词： poly（amidoamine）（PAMAM） dendrimer dendrimer-encapsulated nanoparticles （DENs） infrared car-bon monoxide （IR-CO） probe core-shell nanoparticles

Synthesis of Ni@Au core-shell nanoparticles and Its Applications in Ullmann Reaction as a Synergistic Catalyst

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Chinese Journal of Structural Chemistry 2011年第8期30卷 1122-1126页

作者：祁刚张银华 Department of Chemistry and Biology Yancheng Institute of Technology Yancheng Huaye Pharmaceutical and Chemical Company

The Ni@Au core-shell nanoparticles had been successfully synthesized from aqueous solution by one-step route at room temperature. The Ni@Au nanoparticles can be an excellent catalyst for Ullmann reaction. The advantage of Ni@Au is that the catalyst does not need additional reducing agents. The Au shell can effectively protect the Ni core from oxidation. The Ni core and Au shell have both composited in structure and cooperated in function.

关键词： Ni@Au core-shell nanoparticles Ullmann reaction catalyst

Improvement effect of reversible solid solutions Mg_(2)Ni(Cu)/Mg_(2)Ni(Cu)H_(4)on hydrogen storage performance of MgH_(2)

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Journal of Magnesium and Alloys 2024年第1期12卷 197-208页

作者： Yingyan Zhao Zhibing Liu Jiangchuan Liu Yunfeng Zhu Jiguang Zhang Yana Liu Xiaohui Hu Liquan Li College of Materials Science and Engineering Nanjing Tech University30 South Puzhu RoadNanjing211816PR China Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function Composites Nanjing Tech UniversityNanjing211816PR China

The hydrogen absorption/desorption kinetic properties of MgH_(2)can be effectively enhanced by doping specific catalysts.In this work,MOFs-derived NiCu@C nanoparticles(~15 nm)with regular core-shell structure were successfully prepared and introduced into MgH_(2)(denoted as MgH_(2)-NiCu@C).The onset and peak temperatures of hydrogen desorption of MgH_(2)-11 wt.%NiCu@C are 175.0℃and282.2℃,respectively.The apparent activation energy of dehydrogenated reaction is 77.2±4.5 kJ/mol for MgH_(2)-11 wt.%NiCu@C,which is lower than half of that of the as-milled MgH_(2).Moreover,MgH_(2)-11 wt.%NiCu@C displays great cyclic stability.The strengthening"hydrogen pumping"effect of reversible solid solutions Mg_(2)Ni(Cu)/Mg_(2)Ni(Cu)H_(4)is proposed to explain the remarkable improvement in hydrogen absorption/desorption kinetic properties of MgH_(2).This work offers a novel perspective for the design of bimetallic nanoparticles and beyond for application in hydrogen storage and other energy related fields.

关键词： Magnesium hydride Reversible solid solution core-shell nanoparticles Hydrogen storage performance

Exploring luminescence quenching on lanthanide-doped nanoparticles through changing the spatial distribution of sensitizer and activator

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Nano Research 2024年第5期17卷 4517-4524页

作者： Jiwei Li Yao Xie Renrui Sun Junxun Zhou Lining Sun Department of Chemistry College of SciencesShanghai UniversityShanghai 200444China Department of Physics College of SciencesShanghai UniversityShanghai 200444China School of Medicine Shanghai UniversityShanghai 200444China

Luminescence quench is common in overdoped upconversion nanoparticles.Various methods have been proposed to counteract the adverse effects of concentration quenching on luminescence,but in upconversion nanoparticles that are highly doped with both sensitizers and activators,the factors that contribute to the diminishing of the emission cannot be summarized by a single cause.Herein,a core-shell design is used to spatially separate the sensitizer(Yb^(3+))and activator(Er^(3+))and to modulate the emission by changes in the distribution position as well as the concentration of the dopant ions in order to probe the factors affecting the luminescence.When the sensitizer ions are located in the core,the luminescence intensity of the nanoparticles is significantly weaker than that of the other distribution,which implies that the effect of sensitizer and activator on luminescence in the highly doped state has a different and more complex mechanism.The intensity of the emission is more affected by Yb^(3+)than Er^(3+),which includes not only the self-quenching of Yb^(3+),but also the dominance in the Yb^(3+)-Er^(3+)cross-relaxation.In this finding may provide new ideas for revealing the reasons for the diminished luminescence of highly doped upconversion nanoparticles and thus for enhancing luminescence.

关键词： upconversion luminescence lanthanide ion core-shell nanoparticles concentration quenching cross-relaxation

Manufacturing of Surface Nanostructured Fibers Featuring an Antibacterial Effect by Magnetic Field Transportation of Magnetite@Silver core-shell nanoparticles

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Journal of Materials Science and Chemical Engineering 2017年第12期5卷 1-16页

作者： Roy Buschbeck Franziska Lüttich Sebastian Spange Ronny Kocher Michael Roder Andreas Heft Bernd Grünler Arnd Schimanski Heinrich Lang Surface Engineering Innovent e.V.Technology DevelopmentJenaGermany Inorganic Chemistry Institute of ChemistryTechnischeUniversität ChemnitzChemnitzGermany

Magnetic core-shell nanoparticles of type Fe3O4@Ag were synthesized in gram scale following a combined co-precipitation phase-transfer method and afterwards, processed to nanoparticle polymer (polypropylene and polyamide) composites. These composites were used as sheath material for the fabrication of core-sheath fibers. During the melt spinning process, a magnetic field was applied around the roving, whereby the particles move in the still liquid sheath polymer towards the surface. The produced fiber materials were investigated by AFM showing a nanostructuring of the surface, which was indirectly confirmed by determination of a slight surface tension lowering. Nanoparticle movement was shown by cross-section SEM and EDX measurements. The antibacterial activity of the spun fibers was proven by contacting them with Escherichia coli. A long-term stability of this effect was observable by carrying out a standard washability test. In contrast to previous works this new approach uses no deposition technique to introduce surface changes. It rather applies a magnetic force to move appropriately equipped nanoparticles from the inside of the fiber to the surface. This leads in only one step to a strong superficial anchoring of the particles resulting in a unique combination of long-term stable antibacterial and improved anti-soiling effects.

关键词： Nanocomposites Polymer Fibers core-shell nanoparticles Magnetic Field Treatment Nanostructured Surface

Creating “Hot” Reporter-embedded Hybrid core-shell nanoparticles as SERS-labels

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Creating “Hot” Reporter-embedded Hybrid Core-Shell Nanopar...

Non-cytotoxic nanoparticles re-educating macrophages achieving both innate and adaptive immune responses for tumor therapy

第二十届全国光散射学术会议（CNCLS20）

作者： Enzhong Tan Institute of nano-photoelectronics and high energy physics Department of Mathematics and PhysicsBeijing Institute of Petrochemical Technology

Monodispersed,biocompatible,and readily-functionalized hybrid reporter-embedded triplex core-shell nanoparticles have been prepared in a simple route,each one comprising of a silver nanoparticle（AgNP） core for Raman enhancement,reporter molecules adsorbed on AgNP surface for SERS signature,a carbon（C） shell for protection and isolation,a submonolayer of Au nanoparticles（AuNPs） immobilized atop C layer for further optical enhancement.The electromagnetic field is enhanced remarkably in the intermediary region between inner AgNP and outer AuNPs due to the electromagnetic coupling between the metal NPs,which forms an enhancement ’hot zone’ and is the main contributor for enhanced Raman signals of labeling molecules.The results were proved by the three-dimensional finite-difference time domain（FDTD） simulation.This composite offers a potential platform for immunochemical detection using surface-enhanced Raman scattering（SERS） due to their high sensitivity,good stability and biocompatiblity.This also provides a new platform for insight into SERS enhancement mechanism.

关键词： core-shell nanoparticles optical properties surface enhanced Raman scattering label

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Asian Journal of Pharmaceutical Sciences 2022年第4期17卷 557-570页

作者： Shengmei Wang Xuanjun Liu Minghua Yang Linqi Ouyang Jinsong Ding Shengfeng Wang Wenhu Zhou Department of Pharmacy The Third Xiangya HospitalCentral South UniversityChangshaHunan410013China Xiangya School of Pharmaceutical Sciences Central South UniversityChangshaHunan410013China Postdoctoral Research Station of Clinical Medicine and Department of Pediatrics The Third Xiangya HospitalCentral South UniversityChangshaHunan410013China The First Hospital of Hunan University of Chinese Medicine ChangshaHunan410007China

Macrophages are important antigen-presenting cells to combat tumor via both innate and adaptive immunity,while they are programmed toM2 phenotype in established tumors and instead promote cancer development and metastasis.Here,we develop a nanomedicine that can re-educate M2 polarized macrophages to restore their anti-tumor activities.The nanomedicine has a core-shell structure to co-load IPI549,a PI3Kγinhibitor,and CpG,a Toll-like receptor 9 agonist.Specifically,the hydrophobic IPI549 is self-assembled into a pure drug nano-core,while MOF shell layer is coated for CpG encapsulation,achieving extra-high total drugs loading of 44%.Such nanosystem could facilitate intracellular delivery of the payloads but without any cytotoxicity,displaying excellent biocompatibility.After entering macrophages,the released IPI549 and CpG exert a synergistic effect to switch macrophages from M2 to M1 phenotype,which enables anti-tumor activities via directly engulfing tumor cells or excreting tumor killing cytokines.Moreover,tumor antigens released from the dying tumor cells could be effectively presented by the re-educated macrophages owing to the up-regulation of various antigen presenting mediators,resulting in infiltration and activation of cytotoxic T lymphocytes.As a result,the nanosystem triggers a robust antitumor immune response in combination with PD-L1 antibody to inhibit tumor growth and metastasis.This work provides a non-cytotoxic nanomedicine to modulate tumor immune microenvironment by reprograming macrophages.

关键词： core-shell nanoparticles Metal-organic-framework CpG IPI549 Tumor immunotherapy