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Plant profile,phytochemistry and pharmacology of cordia dichotoma(Indian cherry):A review

Asian Pacific Journal of Tropical Biomedicine 2013年第12期3卷 1009-1016页

作者： Prasad G.Jamkhande Sonal R.Barde Shailesh L.Patwekar Priti S.Tidke Department of Pharmacology School of PharmacyS.R.T.M.University Department of Pharmacology R.C.Patel Institute of Pharmaceutical Education & Research

More than half of the world's population relies on the traditional medicine and major role of the traditional medicine including the use of plant extract and their active *** them,cordia dichotoma Forst.,a small to moderate size plant of family *** called bhokar,lasura,gonda,Indian cherry and *** parts such as leaves,fruit,bark and seed have been reported for possessing antidiabetic,antiulcer,anti-inflammatory,immune-modulator and analgesic *** of fruit,leaves and seed shows the presence of pyrrolizidine alkaloids,coumarins,flavonoids,saponins,lerpenes and *** review focuses on details of geographical distribution,physicochemical parameters,phytoconstituents and pharmacological properties of cordia dichotoma reported so far.

关键词： cordia dichotoma Cytotoxic β-sitosterol Indian cherry Diabetes Pharmacology

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Quinones from cordia species from 1972 to 2023:isolation,structural diversity and pharmacological activities

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Natural Products and Bioprospecting 2023年第1期13卷 93-116页

作者： Rostanie Dongmo Zeukang Jarmo-Charles Kalinski Babalwa Tembeni Eleonora D.Goosen Jacqueline Tembu Turibio Tabopda Kuiate Dominique Serge Ngono Bikobo Maurice Tagatsing Fotsing Alex de Théodore Atchadé Xavier Siwe-Noundou Department of Organic Chemistry Faculty of ScienceUniversity of Yaounde IPO Box 812YaoundeCameroon Department of Biochemistry and Microbiology Faculty of ScienceRhodes UniversityPO Box 94Makhanda 6140South Africa Department of Pharmaceutical Sciences School of PharmacySefako Makgatho Health Sciences UniversityMedunsaPO Box 218Pretoria 0204South Africa Division of Pharmaceutical Chemistry Faculty of PharmacyRhodes UniversityPO Box 94Makhanda 6140South Africa Department of Chemistry Tshwane University of TechnologyPrivate Bag X680Pretoria 0001South Africa

Plants of the genus cordia(Boraginaceae family)are widely distributed in the tropical regions of America,Africa,and *** are extensively used in folk medicine due to their rich medicinal *** review presents a comprehensive analysis of the isolation,structure,biogenesis,and biological properties of quinones from cordia species reported from 1972 to *** were identified as the major quinones in most cordia species and are reported as a chemotaxonomic markers of the *** addition to this property,quinones are reported to display a wider and broader spectrum of activities,are efficient scaffold in biological activity,compared to other classes of compounds reported in cordia,hence our focus on the study of quinones reported from cordia *** 70 types of quinones have been isolated,while others have been identified by phytochemical screening or gas *** the biosynthesis of quinones from cordia species is not yet fully understood,previous reports suggest that they may be derived from geranyl pyrophosphate and an aromatic precursor unit,followed by oxidative cyclization of the allylic methyl *** have demonstrated that quinones from this genus exhibit antifungal,larvicidal,antileishmanial,anti-inflammatory,antibiofilm,antimycobacterial,antioxidant,antimalarial,neuroinhibitory,and hemolytic *** addition,they have been shown to exhibit remarkable cytotoxic effects against several cancer cell lines which is likely related to their ability to inhibit electron transport as well as oxidative phosphorylation,and generate reactive oxygen species(ROS).Their biological activities indicate potential utility in the development of new drugs,especially as active components in drug-carrier systems,against a broad spectrum of pathogens and ailments.

关键词： cordia Boraginaceae Quinones Meroterpenoids Biogenesis Pharmacological activities

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