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Successful hepatic resection for recurrent hepatocellular carcinoma after lenvatinib treatment:A case report

World Journal of Hepatology 2020年第12期12卷 1349-1357页

作者： Hideki Yokoo Hiroyuki Takahashi Masahiro Hagiwara Hiroyoshi Iwata Koji Imai Yoshinori Saito NaotoMatsuno Hiroyuki Furukawa Division of Hepato-Biliary-Pancreatic surgery and Transplant surgery Department of SurgeryAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Department of Gastroenterology Asahikawa-Kosei General HospitalAsahikawa 078-8211HokkaidoJapan

BACKGROUND Lenvatinib has been shown to be noninferior to sorafenib regarding prognosis and recurrence rate in patients with unresectable hepatocellular carcinoma(HCC)who have not received prior systemic *** patients treated with lenvatinib,40%of cases achieved sufficient tumor reduction to make potential surgery ***,the outcomes of such surgery are *** report a successful case of hepatic resection for recurrent HCC after lenvatinib *** SUMMARY A 69-year-old man underwent right anterior sectionectomy for HCC in segment 8 of the *** months later,he was found to have an intrahepatic HCC recurrence that grew rapidly to 10 cm in diameter with sternal bone *** confirming partial response to lenvatinib administration for 2 mo,a second hepatectomy was *** examination showed that 80%of the tumor was *** patient did not develop any adverse effects under lenvatinib *** was discharged at 25 d after *** therapy for bone metastases continued to be given under lenvatinib,and the patient has remained alive for 1 year after the second *** The prognosis of patients with recurrent HCC may be improved by liver resection combined with prior lenvatinib therapy.

关键词： conversion to surgery Lenvatinib Recurrent hepatocellular carcinoma Case report Neoadjuvant therapy Molecular targeted therapy

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