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Adipocytokine profile in children with Kawasaki disease at a mean follow-up period of 5.5 years: A study from North India

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World Journal of Clinical Pediatrics 2022年第4期11卷 360-368页

作者： Dibya Lochan Praharaj Amit Rawat Anju Gupta Kanika Arora Rakesh Kumar Pilania Sagar Bhattad Surjit Singh Pediatric Allergy and Immunology Unit Advanced Pediatrics CentrePost Graduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND Kawasaki disease(KD)is an acute self-limited vasculitis with a predilection for coronary *** with KD may have altered lipid metabolism and abnormal lipid profiles that may last for prolonged ***,there is a paucity of literature on the role of adipocytokines in *** To estimate the levels of adipocytokines(adiponectin,leptin and resistin)during the convalescent phase of *** Twenty children,who had KD at least three years earlier,were enrolled in this *** addition,20 healthy controls were also *** and laboratory profiles of patients were obtained from hospital *** adiponectin,leptin and resistin levels were estimated by enzyme-linked immunosorbent *** Mean age of the patients in the study group was 10.15±3 years and the male:female ratio was 1.5:*** serum resistin levels in patients with KD(27.77 ng/mL;[IQR:18.66,48.90])were decreased compared to controls(21.20 ng/mL;[IQR:14.80,27.00])(P=0.04).Median serum leptin levels in cases and controls were 1.83 ng/mL;(IQR:1.13,3.80),and 1.10 ng/mL;(IQR:0.41,2.88),respectively(P=0.09).Median serum adiponectin levels were similar in both cases(12.20μg/mL;[IQR:9.76,17.97])and controls(13.95μg/mL;[IQR:11.17,22.58]);(P=0.18).There was no significant difference in all 3 adipocytokines between children with(4/20)and without coronary artery abnormalities(16/20).CONCLUSION Serum resistin levels were significantly elevated in patients with KD during the convalescent phase compared to *** leptin levels appeared to be higher in patients with KD,although the difference was not statistically *** levels were similar in both cases and *** resistin and leptin levels may partially explain lipid perturbations observed during the convalescent phase of KD.

关键词： Adipocytokines Adiponectin Resistin Leptin Lipid metabolism Kawasaki disease convalescent phase

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Investigate Targeted Factors to Achieve Prediction Goal in Stroke Convalescence in Terms of Causal Relationships of Prediction Error

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Open Journal of Therapy and Rehabilitation 2022年第4期10卷 244-256页

作者： Takashi Kimura Department of Physical Therapy ASO Rehabilitation College Fukuoka Japan Department of Rehabilitation Medicine Saga University Hospital Saga Japan

Background and Purpose: To investigate target functional independence measure (FIM) items to achieve the prediction goal in terms of the causal relationships between prognostic prediction error and FIM among stroke patients in the convalescent phase using the structural equation modeling (SEM) analysis. Methods: A total of 2992 stroke patients registered in the Japanese Rehabilitation Database were analyzed retrospectively. The prediction error was calculated based on a prognostic prediction formula proposed in a previous study. An exploratory factor analysis (EFA) then the factor was determined using confirmatory factorial analysis (CFA). Finally, multivariate analyses were performed using SEM analysis. Results: The fitted indices of the hypothesized model estimated based on EFA were confirmed by CFA. The factors estimated by EFA were applied, and interpreted as follows: “Transferring (T-factor),” “Dressing (D-factor),” and “Cognitive function (C-factor).” The fit of the structural model based on the three factors and prediction errors was supported by the SEM analysis. The effects of the D- and C-factors yielded similar causal relationships on prediction error. Meanwhile, the effects between the prediction error and the T-factor were low. Observed FIM items were related to their domains in the structural model, except for the dressing of the upper body and memory (p < 0.01). Conclusions: Transfer, which was not heavily considered in the previous prediction formula, was found in causal relationships with prediction error. It is suggested to intervene to transfer together with positive factors to recovery for achieving the prediction goal.

关键词： Prediction Error Functional Independence Measure Stroke convalescent phase Structural Equation Modeling

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