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Prognostic value of controlling nutritional status score for postoperative complications and biochemical recurrence in prostate cancer patients undergoing laparoscopic radical prostatectomy

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Current Urology 2024年第1期18卷 43-48页

作者： Tianyu Xiong Xiaobo Ye Guangyi Zhu Fang Cao Yun Cui Liming Song Mingshuai Wang Wahafu Wasilijiang Nianzeng Xing Yinong Niu Department of Urology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Urology Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Urology Cancer Hospital Chinese Academy of Medical SciencesBeijingChina

Background:controlling nutritional status(CONUT)score was used for screening the preoperative nutritional *** correlation between the CONUT score and the prognosis of patients with prostate cancer(PCa)has yet to be ***,we analyzed the prognostic value of CONUT scores in patients with PCa who underwent laparoscopic radical *** and methods:Data of 244 patients were retrospectively *** variables and follow-up data were *** patients were categorized into 2 groups according to their preoperative CONUT *** complication and incontinence rates were also *** Kaplan-Meier method was used to estimate the median biochemical recurrence-free survival(BCRFS)between the 2 *** and multivariate Cox regression analyses were performed to identify the potential prognostic factors for ***:Patients were categorized into the low-CONUT group(CONUT scorescore≥3,n=37).The high-CONUT group had a higher overall complication rate(40.5%vs.19.3%,p=0.004),a higher major complication rate(10.8%vs.3.9%,p=0.013),and longer postoperative length of stay(8 days vs.7 days,p=0.017).More fever,urinary infection,abdominal infection,scrotal edema,rash,and hemorrhagic events(all p valuesscore≥3 was an independent risk factor for a shorter BCRFS(hazards ratio,1.842;p=0.026).Conclusions:The CONUT score is a useful predictive tool for higher postoperative complication rates and shorter BCRFS in patients with PCa who undergo laparoscopic radical prostatectomy.

关键词： controlling nutritional status score Prostate cancer Laparoscopic radical prostatectomy Complication Biochemical recurrence

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Value of the controlling nutritional status score and psoas muscle thickness per height in predicting prognosis in liver transplantation

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World Journal of Clinical Cases 2021年第35期9卷 10871-10883页

作者： Xing Dai Ben Gao Xin-Xin Zhang Jiang Li Wen-Tao Jiang Department of Liver Transplant The First Central College of Tianjin Medical UniversityTianjin 300110China Department of Endocrinology Tianjin Medical University Chu Hsien-I Memorial HospitalTianjin 300134China Department of Liver Transplant Tianjin First Central HospitalTianjin 300110China

BACKGROUND Patients with end-stage liver disease usually have varying degrees of malnutrition,and severe malnutrition may affect the prognosis of patients after liver transplantation(LT).However,there is no recommended standard for the nutrition assessment of patients waiting for LT,and it is unknown whether malnutrition has an impact on the occurrence of postoperative *** The study aim was to investigate the value of the controlling nutritional status(CONUT)score and psoas muscle thickness per height(PMTH)in predicting prognosis in *** We retrospectively analyzed the clinical data of 313 patients who underwent classic orthotopic LT from January 2016 to December 2018 in Tianjin First Central Hospital affiliated with Tianjin Medical *** CONUT score is derived from the preoperative serum albumin and total cholesterol levels,and total lymphocyte *** were divided into low(≤4),medium(5–8),and high(9–12)CONUT score groups perioperative characteristics,Clavien-Dindo grade III/IV/V postoperative complications,graft loss and infection,and cumulative postoperative survival in the three groups were compared 3 mo after *** was calculated as the ratio of the transverse thickness of the psoas muscle in the umbilical plane to the height of the *** cutoff values of receiver operating characteristic curves were determined separately for men and *** values were 14.1 cm/m2 for women and 17.9 cm/m2 for *** patients were then divided into low and high PMTH groups by the cutoff *** comparison of data between the two groups was the same as *** Patients with medium and high CONUT scores had lower preoperative serum hemoglobin,more intraoperative red blood cell(RBC)transfusions,longer postoperative intensive care unit stay and hospital stays,higher 7 and 14 preoperative-day serum bilirubin levels,and a higher incidence of postoperative grade III/IV complications and infections than patients with low CONUT scor

关键词： Liver transplantation controlling nutritional status score Psoas muscle thickness per height Nutrition assessment Complications Prognosis

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Prognostic significance of a combined and controlled nutritional status score and EBV-DNA in patients with advanced nasopharyngeal carcinoma:a long-term follow-up study

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Cancer Biology & Medicine 2022年第4期19卷 551-564页

作者： Hui Lu Shanshan Guo Liting Liu Qiuyan Chen Yujing Liang Sailan Liu Xuesong Sun QingnanTang Xiaoyun Li Ling Guo Haoyuan Mo Linquan Tang Haiqiang Mai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060China Department of Radiation Oncology Guangzhou Concord Cancer CenterGuangzhou 510045China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterGuangzhou 510060China

Objective:Several studies have reported that the controlling nutritional status(CONUT)score is a prognostic predictor for survival among patients with different types of *** assessed the prognostic value of changes in the CONUT score during treatment and theΔCONUT-EBV DNA score in patients with advanced nasopharyngeal carcinoma(NPC).Methods:We retrospectively analyzed 433 patients with advanced NPC having no evidence of metastasis from January 2007 to June 2011;the patients underwent radical concurrent chemoradiotherapy(CCRT)at Sun Yat-sen University Cancer Center and were grouped based on theirΔCONUT andΔCONUT-EBV DNA ***-Meier curves were used to compare the patient outcomes according to the cut-offΔCONUT score and theΔCONUT-EBV DNA scoring ***:Among all patients,overall survival(OS)was independently predicted by a highΔCONUT score(P=0.031)and high EBV DNA(Pscore[OS area under the curve(AUC)=0.621;progression free survival(PFS)-AUC=0.612;distant metastasis-free survival(DMFS)-AUC=0.622]was more predictive of OS,PFS,and DMFS in patients with advanced NPC than theΔCONUT score(OS-AUC=0.547;PFS-AUC=0.533;DMFS-AUC=0.522)and pretreatment plasma EBV DNA levels alone(OS-AUC=0.600;PFS-AUC=0.591,DMFS-AUC=0.610).TheΔCONUT-EBV DNA score was significantly correlated with OS,PFS,and DMFS in patients with advanced NPC treated with ***:TheΔCONUT-EBV DNA score may be useful in clinical practice as a convenient biomarker for predicting the outcomes in patients with advanced NPC treated with CCRT.

关键词： controlling nutritional status score Epstein-Barr virus deoxyribonucleic acid nasopharyngeal carcinoma prognosis predictive factor

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