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S-1 in the treatment of pancreatic cancer

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World Journal of Gastroenterology 2014年第41期20卷 15110-15118页

作者： Kentaro Sudo Kazuyoshi Nakamura Taketo Yamaguchi Department of Gastroenterology Chiba Cancer Center

S-1 is an oral 5-fluorouracil(5-FU) prodrug,which is designed to improve the antitumor activity of 5-FU by inhibiting dihydropyrimidine dehydrogenase,the key enzyme of 5-FU catabolism.Recently,two important studies on the clinical use of S-1 for pancreatic cancer have been reported from Japan.In the first study(GEST study),S-1 demonstrated non-inferiority to gemcitabine(GEM) in overall survival(OS) for metastatic or locally advanced pancreatic cancer,but combination chemotherapy with GEM and S-1 did not show superiority to GEM in OS.In the second study(JASPAC-01 study),S-1 showed superiority to adjuvant chemotherapy with GEM in OS in patients with resected pancreatic cancer.In addition to GEM,S-1 is now regarded as the key drug in the management of pancreatic cancer in Japan.To date,many studies have investigated the effectiveness of S-1 in various settings,such as first-line chemotherapy for metastatic or locally advanced pancreatic cancer,second-line chemotherapy after GEM failure,and chemoradiotherapy for locally advanced disease.In this review,we focus on recent clinical trials of S-1-based chemotherapy for advanced pancreatic cancer.

关键词： Pancreatic cancer S-1 Chemotherapy Randomized cont

Ex-factory Prices of Major Chemicals Quoted by Shanghai Zhongshan Chemical Market in February 2009

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China Chemical Reporter 2009年第7期20卷 25-26页

Investment Program of Polyacrylamides in SNF

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China Chemical Reporter 2009年第32期20卷 22-22页

Over the last 10 years SNF has emerged as a major producer of polyacrylamides with totalannual sales of more than 300 000 tons. The main applications are water treatment,mining, paper making and oil recovery.SNF has p... 详细信息

关键词： producer invested emerged progressively today cont

INSTRUCTIONS TO AUTHORS

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World Journal of Stem Cells 2014年第5期6卷 658-662页

GENERAL INFORMATION World Journal of Stem Cells(World J Stem Cells,WJSC,online ISSN1948-0210,DOI:10.4252),is a peer-reviewed open access(OA)academic journal that aims to guide clinical practice and improve diagnostic ... 详细信息

关键词： editorial reviewers citation cited http write cont

Celanese Announces Emulsions Expansion in China

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China Chemical Reporter 2009年第31期20卷 23-23页

On October 26th, Celanese Corporation (NYSE: CE) announced it is expanding itsvinyl acetate/ethylene (VAE) manufacturing facility at its Nanjing, China, integratedchemical complex. The investment will support continued growth plans for theCelanese Emulsion Polymers business throughout Asia, including China, India andSoutheast Asia and Australia. The expanded facility will double the company’s

关键词： facility Nanjing expanding expanded Australia cont

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GEOPHYSICS

Abstracts of Chinese Geological Literature 2008年第2期24卷 21-24页

20080759 Akira Yamada(Geodynamics Research Center,Ehime University,Matsuyama);Zhao Dapeng Mapping the 660 km Discontinuity under Japan Islands Using Mantle Reflected Waves(Earth Science Frontiers,ISSN1005-2321,CN11-3370,14(3),2007,p.47-56,5 illus.,1 table,38 refs.)Key words:discontinuities,reflection methods,Japan The broadb and waveform records from

关键词： waveform records beneath mantle Mapping crust cont

Silberline Strengthens Commitment in Asia with Yasida Acquisition

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China Chemical Reporter 2008年第34期19卷 7-7页

On November 24th,Silberline announced the ac-quisition of Yasida and Aesthetic Color-Tech(Jinan)Co.,Ltd.from AArbor Intemational Corp.The companies manufacture

关键词： manufacture companies Jinan Shandong consumer cont

The Current Breeding Situation and Development Strategies on High-quality Inbred Rice in Guangxi

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Asian Agricultural Research 2013年第6期5卷 27-30页

作者： Guanglin LIU Yuanmeng CHEN Chuanhua CHEN Xianbin JIANG Qunchang LUO Rice Research Institute Guangxi Academy of Agricultural Sciences Nanning Sub-center of the National Center for Rice Improvement

According to the rice quality,production and resistance of 50 high-quality inbred rice varieties bred and examined and approved in Guangxi during the period 2000-2011,we analyze the current breeding situation and existing problems concerning high-quality inbred rice va- riety in Guangxi: the rice quality has been greatly improved,but the amylose content is still low; a series of scented rice varieties with high quality and high yield have been bred,such as Zhongguangxiang No. 1,Sanxiang 628,Guixiang No. 1,Liufengxiangzhan,Jiafuxiang No. 1, Zhaoxiang No. 1; the production of high-quality inbred rice during the period 2009-2011 was significantly enhanced,annually more than 66 00 kg / ha,but the disease resistance of rice variety bred was generally poor,and disease-resistant breeding stuck in the mud. Henceforth it is necessary to be oriented by the rice market,and take the rice type with long grain,high adhesive strength,medium-low amylose content and low chalkiness degree as the breeding objectives; introduce the existing high-quality variety resources with medium amylose content at home and abroad,then directly use them or innovate upon them as hybrid strain; take the thick-and-long-grain rice type as breeding objectives,and further improve the yield per unit area of high-quality inbred rice by improving the thousand-grain weight; increase capital investment,improve breeding techniques,strengthen disease-resistant and degeneration-resistant breeding,and improve the application of modern biotechnology in the breeding of high-quality inbred rice.

关键词： High-quality inbred rice Rice quality Amylose cont

METAMORPHIC PETROLOGY

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Abstracts of Chinese Geological Literature 2010年第4期26卷 45-49页

20102292 Cao Shuyun(Geoscience Centre of the University of Gttingen,Goldschmidtstr,Go¨ttingen 337077 Germany);Liu Junlai Timing of Initiation of Left-Lateral Slip along the Ailao Shan-Red River Shear Zone:Microstructural,Texture and Thermochronological Evidence from High Temperature Mylonites in Diancangshan Mountains,SW China(Acta Geologica Sinica,ISSN0001-5717,CN11-1951/P,83(10),2009,p.

关键词： Initiation metamorphic zircon volcanic dating cont