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Rhinofacial conidiobolomycosis in an immunocompetent 30-year-old male:A case report

Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 329-331,I0001页

作者： Sourav Kundu Sambudhya Chakraborty Department of Tropical Medicine School of Tropical MedicineKolkataWest BengalIndia

Rationale:Fungal rhinosinusitis is a rare entity in immunocompetent patients and is a diagnostic *** is a rare cause of fungal rhinosinusitis which happens to affect immunocompetent *** concerns:A 30-year-old male patient complained of painless progressive swelling of nose for 5 years and painless progressive swelling of upper lip for 4 years associated with nasal obstruction for 5 ***:Rhinofacial ***:Systemic anti-fungals and saturated solution of potassium ***:Swelling initially reduced but again increased eventually as he discontinued ***:Proper adherence to drugs and need for facial reconstructive surgery may need to be considered in such cases of conidiobolomycosis.

关键词： conidiobolomycosis Fungus Rhinosinusitis Tropical Rhino facial Entomophthoramycosis

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Rhinofacial Entomophthoromycosis

Rhinofacial Entomophthoromycosis

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中国菌物学会2018年学术年会

作者： Jazeer A.Khader Cunwei Cao Guangxi Medical University First Affiliated Hospital

An immunocompetent 22-year-old man from southern China presented to the dermatology clinic with a 3-month history of progressive nasal and maxillofacial swelling. He reported that during the past 3 years he had had episodes of facial swelling for which he had received multiple treatments, including glucocorticoids and antibiotics. The physical examination revealed erythema, edema, and tenderness over the nasal dorsum and forehead, extending to the soft tissue around both eyes（Panel A）, that correlated with soft-tissue thickening on computed tomography. Biopsy specimens were obtained from multiple sites, including the forehead and the nose. Histopathological examination of a specimen from inside the nose revealed granulomatous inflammation and fungal elements surrounded by eosinophilic material. A fungal culture grew Conidiobolus coronatus（Panel B）, the identity of which was confirmed by polymerase-chain-reaction *** entomophthoromycosis was diagnosed. conidiobolomycosis, a type of entomophthoromycosis, is a rare subcutaneous mycosis that can occur in immunocompetent persons in tropical and subtropical regions. It affects the upper respiratory mucosa and adjacent subcutaneous tissues. Infection probably results from the inhalation of fungal pathogens or from trauma. The patient received itraconazole, trimethoprim–sulfamethoxazole, and a 10% potassium iodide solution for 6months, and the symptoms had fully resolved without relapse after 1 year of follow-up.

关键词： conidiobolomycosis Rhinofacial entomophthoromycosis conodiobolus coronatus

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