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Clinical Efficacy and Transcriptomic Analysis of congrong shujing granules (苁蓉舒痉颗粒) in Patients with Parkinson's Disease of Shen (Kidney) Essence Deficiency Syndrome

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Chinese Journal of Integrative Medicine 2020年第6期26卷 412-419页

作者： CHEN Shi-ya XIAO Shao-jian LIN You-ning LI Xi-yu XU Qian YANG Sha-sha HUANG Lian-hong CAI Jing Geriatrics Department the Third Affiliated People's Hospital of Fujian University of Traditional Chinese MedicineFuzhou(350122)China College of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou(350122)China College of Medical Technology and Engineering Shengli Clinical Medical College of Fujian Medical UniversityFuzhou(350001)China Department of Rehabilitation Medicine Fujian Provincial HospitalFuzhou(350001)China

Objective:To evaluate the clinical efficacy and safety of congrong shujing granules(苁蓉舒痉颗粒,CSGs)in treating patients with Parkinson's disease(PD)and Chinese medicine(CM)syndrome of Shen(Kidney)essence deficiency,and to investigate the potential mechanism involving efficacy through a transcriptome sequencing ***:Eligible PD patients with syndrome of Shen essence deficiency were randomly assigned to a treatment group or a control group by a random number table,and were treated with CSGs combined with Western medicine(WM),or placebo combined with WM,*** courses of treatment lasted for 12 *** Unified Parkinson's Disease Rating Scale(UPDRS)score,the PD Question-39(PDQ-39)score,CM Syndrome Scale score,and drug usage of all patients were evaluated before and after *** was evaluated by clinical laboratory tests and *** samples from 6 patients in each group were collected before and after the trial and used for transcriptomic analysis by gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway *** expressed genes were validated using reverse transcription-polymerase chain ***:A total of 86 PD patients were selected from the Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine between January 2017 and December ***,72 patients completed the trial,including 35 in the treatment group and 37 in the control *** compared with the control group after treatment,patients in the treatment group showed significant decreases in UPDRS sub-Ⅱscore,PDQ-39 score,CM syndrome score,and Levodopa equivalent dose(P0.05).A possible mechanism of clinical efficacy was proposed that involved regulating cell metabolism-related processes and ribosome-related *** with CSGs had shown to affect relevant gene

关键词： congrong shujing granules Parkinson's disease randomized controlled trial RNA-sequencing transcriptomics Chinese medicine

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