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Retrospective Cohort Study to Investigate Pregnancy Outcomes in a Population of Advanced Maternal Age congolese women of Kinshasa: A Study Protocol

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1398-1406页

作者： Anne Kapinga Mutshiaudi Thérèse Mikoka Walumpumpu Nicodem Nkutu Kimpu Joelle Lumaya Ambis Andy Mbangama Muela Roger Mbungu Mwimba Kahindo P. Muyalalo Department of Gynecology and Obstetrics Cliniques Universitaires de Kinshasa Kinshasa Congo Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Congo

Introduction: Pregnancies at advanced maternal age (AMA) are those occurring after the age of 35 years old. They carry a high risk of maternal-fetal morbidity and mortality, thus constituting a public health problem. Several African countries have reported an upward trend in both the age of childbirth and the frequency of women with AMA over the past 20 years. In the Democratic Republic of Congo (DRC), where maternal and neonatal morbidity and mortality remain very high, data on AMA pregnancies go back more than 20 years. Objective: We propose evaluating obstetrical outcomes among women in AMA in our setting and the associated factors. Methods: This retrospective cohort study will be conducted in two healthcare facilities (ESS) in Kinshasa. The study population will consist of all women who delivered a single fetus after 28 weeks of gestation between January 2012 and December 2022 (10 years) in the selected ESS. The data collected will be analyzed using R software version 4.2.0. Quantitative variables will be summarized as means with standard deviation or medians with interquartile range. Qualitative variables will be presented as proportions (%). Multivariate logistic regression will be used to determine the main maternal-fetal complications associated with AMA and predictors of obstetric outcomes. P Discussion: The high maternal and infant mortality rates in DRC are among the highest in the world. The context of maternal age has become a topic of growing interest due to its potential implications for the health of women and newborns, it is crucial to identify the risk factors associated with obstetric outcomes by identifying obstetrical outcomes associated with advanced maternal age in the DRC. Many congolese women tend to start their maternity journey at a relatively young age. However, there is also an emerging trend towards delayed childbearing, particularly in urban areas and among women with access to education and family planning services. Conclusion: The re

关键词： Advanced Maternal Age Adverse Maternal and Perinatal Outcome congolese women Kinshasa

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Wrist circumference: A new marker for insulin resistance in African women with polycystic ovary syndrome

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World Journal of Diabetes 2020年第2期11卷 42-51页

作者： Chantal Anifa Amisi Massimo Ciccozzi Paolo Pozzilli Endocrinology and Diabetes Unit Department of MedicineUniversita Campus Bio-medico di RomeRome 00128Italy Medical Statistics and Epidemiology Unit Department of MedicineUniversita Campus Bio-medico di RomeRome 00128Italy

BACKGROUND Insulin resistance(IR)is the main complication found in 35%-80%of women with polycystic ovary syndrome(PCOS).However,there is no definite consensus regarding which marker to use for its assessment in PCOS *** has shown that hyperinsulinemia is correlated with increased bone *** that most women with PCOS are insulin resistant,which is independent from body fat and characterized by hyperinsulinemia,it could be hypothesized that there would be an increased bone mass in the patient as a ***,increased bone mass could be measured using the wrist circumference *** To assess the wrist circumference as an easy-to-detect marker of IR in congolese women with *** Seventy-two congolese women with PCOS and seventy-one controls from the same ethnic group,were enrolled in the study(mean age 24.33±5.36 years).Fasting biochemical parameters,and the Homeostasis Model Assessment of insulin resistance(HOMA-IR)and body composition were *** nondominant wrist circumference was measured manually,as was the waist circumference(WC),hip circumference,height and *** measures included evaluation of body mass index(BMI),Waist-to-Height(WHtR)and Waist-to-hip ratio(WHR).In addition,body composition was assessed by Bioelectrical Impedance Analysis using a body fat *** The non-dominant wrist circumference was more closely correlated with HOMAIR(r=0.346;P=0.003)and was the best anthropometrical marker correlated with IR(P=0.011)compared with other anthropometrical markers in women with PCOS:Dominant Wrist Circumference(r=0.315;P=0.007),Waist Circumference(WC)(r=0.259;P=0.028),BMI(r=0.285;P=0.016),WHR(r=0.216;P=0,068)and WHtR(r=0.263;P=0.027).The diagnostic accuracy of the non-dominant wrist circumference for the presence or absence of IR using Receiver-operating characteristic(ROC)curve analysis showed that the area under the ROC curve was 0.72.A cutoff value for the non-dominant wrist circumference of 16

关键词： Wrist circumference Insulin resistance Polycystic ovary syndrome congolese women Sub-Saharan African women Marker of insulin resistance Homeostasis Model Assessment of insulin resistance Easy-to-detect marker

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