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Kiran Nandivada’s Stuck Blade in a Grinder Jar Degenerative Cascade by LSTV at L5-S1

Open Journal of Orthopedics 2024年第1期14卷 12-21页

作者： Venkata Satya Kumar Kiran Nandivada Nadavinamani Shivanand Raghavendra Nandivada Nikhil Bharadwaja Moola Sohith Mahadeva Reddy Ahmed Usama Rizvi Nandivada Ortho Spine Surgeon & Rheumatologist Abu Dhabi United Arab Emirates Senior Orthopedic Surgeon & Rheumatologist Abu Dhabi United Arab Emirates General Practitioner Visakhapatnam India Department of Medicine Kamineni Institute of Medical Sciences Telangana India Department of Medicine Tbilisi State Medical University Tbilisi Georgia

Background: Mario Bertolotti, (1917) described LSTV-Lumbar spinal transitional vertebra as Bertolotti Syndrome a century ago and associated low back pain with it. Yet, it needs to be given significance in general orthopaedic practice even now, and radiologists underreport it. LSTV is a congenital anatomical anomaly that Castellvi classified into four varying types. Purpose: I titled this phenomenon “Kiran Nandivada’s stuck blade in a grinder jar degenerative cascade by LSTV at L5-S1” to clearly explain how an abnormal mega-transverse apophysis with its various variations affects the weight-bearing mechanics as the L5-S1 which is a vital junction where the maximum body weight is directed into both the sacroiliac joints and if a transitional vertebra occurs it becomes detrimental and abnormally redirects the load-bearing forces and leads to a progressive degenerative cascade both proximally and distally. As the L5 vertebral rotations and other movements of flexion, extensions, lateral flexion are stuck like a bent grinder blade, the other areas of the region are damaged progressively as the pelvis, just like the grinder motor tries to move it, resulting in overheating and maybe even a burnout results in the form of facet arthritis, disc degeneration in the normal disc above, the transitional disc at L5-S1, foraminal osteophytes causing radiculopathy, sacroiliac joint arthritis. Material and Methods: Around 200 X-rays of children and adults with this congenital anomaly have been studied between 2020 and 2023. This is a retrospective study. Results: 1) Our study showed an Increased incidence of LSTV at 15%. 2) Patients ranged from asymptomatic, atypical lumbago to classical lumbago with sciatica and claudication. Findings supported facet and sacroiliac joint arthritis and the pain, relieved with physiotherapy, posture corrections, weight reduction, and lifestyle precautions, negating the need for local steroid injections, radiofrequency ablation or surgical excision as

关键词： LSTV Bertolotti Syndrome Transitional Vertebra Facet Tropism congenital dysplasia

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Innate Immunity in the Development of Connective Tissue dysplasia: Pilot Study in Children with congenital Hip Dislocation

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Journal of Biosciences and Medicines 2022年第7期10卷 155-170页

作者： Anna Borisovna Yazykova Irina Vladimirovna Musikhina Maksim Valeryevich Vlasov Petr Stanislavovich Vvedenskiy Mikhail Yuryevich Lebedev Biochemistry Department Privolzhsky Research Medical University Nizhniy Novgorod Russian Federation Department of Children Orthopedics Privolzhsky Research Medical University Nizhniy Novgorod Russian Federation Laboratory of Immunology Privolzhsky Research Medical University Nizhniy Novgorod Russian Federation

Introduction: Observing and treatment of hip dysplasia in children have always been in the sphere of interest of modern molecular medicine. The role of molecular factors in the formation of connective tissue dysplasia in children is considered crucial for such multisystem disorders, and connective tissue dysplasia progressing involves immune system parameters and biochemical markers. The aim of this work was to establish the relationship between immune status indicators and biochemical markers of connective tissue using bioinformatics and modeling methods. Materials and Methods: 27 patients with congenital hip dislocation, admitted to the University Clinic of Privolzhsky Research Medical University, Department of children orthopedics for surgical treatment, were examined. Determination of 10 blood parameters was conducted by modern biochemical and immunological methods. Statistica 12.0 software from StatSoft was used for statistical data processing. Methods of nonparametric statistics were used since the samples in the control group partially follow the normal distribution. Correlation methods and regression modeling methods were used to evaluate the relationship of indicators. Results and Conclusion: In our investigation we have shown the presence of statistical and mathematical interactions between the parameters of innate immunity and indicators of connective tissue metabolism. The leading role of the immune system in the development of pathologies associated with connective tissue dysplasia is assumed. In further investigations it is necessary to clarify the role hypoxia in HIF-1 stimulated control of skeletal dysplasia, collagen modification, connective tissue dysplasia development.

关键词： congenital dysplasia congenital Hip Dislocation Connective Tissue Metabolism Biomarkers Immune System

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Best bone of acetabulum for cup component placement in Crowe types Ⅰto Ⅲ dysplastic hips:a computer simulation study

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Chinese Medical Journal 2019年第23期132卷 2820-2826页

作者： Lin-Li Zheng Yang-Yang Lin Xiao-Yan Zhang Qian-Hui Ling Wei-Ming Liao Pei-Hui Wu Department of Joint Surgery the First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Rehabilitation Medicine the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510655China College of Computer Science&Software Engineering Shenzhen UniversityShenzhenGuangdong 518060China Zhongshan Medical School Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Background:During cup implantation,vertical height of the cup center(V-HCC)should be precisely controlled to achieve sufficient bone-cup coverage(BCC).Our study aimed to investigate the acetabular bone stock and the quantitative relationship between V-HCC and BCC in Crowe types Ⅰto Ⅲ ***:From November 2013 to March 2016,pelvic models of 51 patients(61 hips)with hip dysplasia were retrospectively reconstructed using a computer *** height and doom thickness were measured on the mid-acetabular coronal cross section.V-HCC was defined as the vertical distance of cup rotational center to the interteardrop line(ITL).In the cup implantation simulation,the cup was placed at the initial preset position,with a V-HCC of 15 mm,and moved proximally by 3-mm *** each level,the BCC was automatically calculated by *** of variance and Kruskal-Wallis test were used to compare the differences between ***:There were no significant between-group differences in maximum thickness of the acetabular doom;however,peak bone stock values were obtained at heights of 41^3±5.14 mm(Crowe typeⅠ),47.58±4.10 mm(Crowe type Ⅱ),and 55.78±3.64 mm(Crowe type Ⅲ)above the *** 15 mm of V-HCC,median BCC was 78%(75-83%)(Crowe type Ⅰ),74%(66-71%)(Crowe type Ⅱ),and 61%(57-68%)(Crowe type Ⅲ).To achieve 80%of the BCC,the median V-HCC was 16.27(15.00-16.93)mm,18.19(15.01-21.53)mm,and 24.13(21.02-28.70)mm for Crowe typesⅠ,Ⅱ,and Ⅲ hips,***:During acetabular reconstruction,slightly superior placement with V-HCC<25 mm retained sufficient bone coverage in CroweⅠto Ⅲ hips.

关键词： Computer simulation congenital dysplasia Hip Three-dimensional image Total-hip replacement

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