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Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration

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Bioactive Materials 2023年第12期30卷 85-97页

作者： Pengxiang Yang Yong Peng Xiu Dai Jing Jie Deling Kong Xiaosong Gu Yumin Yang Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education Co-Innovation Center of NeuroregenerationNMPA Key Laboratory for Researchand Evaluation of Tissue Engineering Technology ProductsNantong University226001NantongPR China Institute of Cancer Prevention and Treatment Heilongjiang Academy of Medical ScienceHarbin Medical University150081HarbinPR China Department of Clinical Laboratory The Second Affiliated Hospital of Nantong University226001NantongPR China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin300071PR China

Tissue regeneration requires exogenous and endogenous signals,and there is increasing evidence that the exogenous microenvironment may play an even more dominant role in the complex process of coordinated multiple *** short-distance peripheral nerve showed a spontaneous regenerative phenomenon,which was initiated by the guiding role of ***,it cannot sufficiently restore long-distance nerve injury by *** on this principle,we firstly constructed a proinflammatory model to prove that abnormal M2 expression reduce the guidance and repair effect of long-distance ***,a bionic peptide hydrogel scaffold based on self-assembly was developed to envelop M2-derived regenerative cytokines and extracellular vesicles(EVs).The cytokines and EVs were quantified to mimic the guidance and regenerative microenvironment in a direct and mild *** bionic scaffold promoted M2 transformation in situ and led to proliferation and migration of Schwann cells,neuron growth and motor function ***,the peptide scaffold combined with CX3CL1 recruited more blood-derived M2 macrophages to promote long-distance nerve recon***,we systematically confirmed the important role of M2 in regulating and restoring the injury peripheral *** bionic peptide hydrogel scaffold mimicked and remodeled the local environment for M2 transformation and recruitment,favoring long-distance peripheral nerve *** can help to explicate regulative effect of M2 may be a cause not just a consequence in nerve repair and tissue integration,which facilitating the development of pro-regenerative biomaterials.

关键词： Bionic peptide scaffolds Peripheral nerve regeneration Macrophages conditional media Immune microenvironment

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