检索结果-南通市图书馆

Neuroprotective Effect of compound anisodine in a Mouse Model with Chronic Ocular Hypertension

Chinese Medical Journal 2015年第19期128卷 2652-2657页

作者： Wen-Dong Liu Lan-Lan Chen Ce-Ying Shen Li-Bin Jiang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China

Background：compound anisodine （CA） is a compound preparation made from hydrobromide anisodine and procaine *** former is an M-choline receptor blocker with the function of regulating the vegetative nervous system,improving microcirculation,and so *** latter is an antioxidant with the activities *** study aimed to investigate the potential neuroprotection of CA,which affects the degeneration of the retinal ganglion cells （RGCs） in an animal model with chronic ocular ***：Female C57BL/6J mice （n =24） were divided randomly into four groups：Normal control group without any treatment （Group A,n =6）;CA control group with feeding the CA solution （Group B,n =6）;microbeads （MBs） control group with injecting MB into the anterior chamber （Group C,n =6）;CA study group with MB injection and with feeding the CA solution （Group D,n =6）.Intraocular pressure （IOP） was measured every 3 days after MB *** the 21st day,neurons were retrograde-labeled by Fluoro-Gold （FG）.Animals were sacrificed on the 27th *** flat mounts were stained immunohistologically by β-Ⅲ-***-retrograde-labeled RGCs,β-Ⅲ-tubulin-positive RGCs,and β-Ⅲ-tubulin-positive nerve fibers were ***：Mice of Groups C and D expressed the incidence of consistent IOP elevation,which is above the IOP level of Group A with the normal *** is no significant difference in IOP between Groups A and B （P ＞ 0.05）.On the 27th day,there were distinct loss in stained RGCs and nerve fibers from Groups C and D compared with Group A （all P ＜ 0.00l）.The quantity was significantly higher in Group D as compared to Group C （all P ＜ 0.00l） but lower than Group A （all P ＜ 0.001）.There was no significant difference in the quantity of RGCs and nerve fibers between Groups A and B （all P ＞ 0.05）.Conclusions：These findings suggest that CA plays an importantly neuroprotective role on RGCs in a mouse model with chronic ocular hypertension.

关键词： compound anisodine Glaucoma Neuroprotection Ocular Hypertension

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：