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composite intestinal adenoma-microcarcinoid:An update and literature review

World Journal of Gastrointestinal Endoscopy 2021年第12期13卷 593-606页

作者： Zhi-Yan Fu Michel Kmeid Mahmoud Aldyab Stephen M Lagana Hwajeong Lee Pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew YorkNY 10032United States

composite intestinal adenoma-microcarcinoid(CIAM)is a rare intestinal lesion consisting of conventional adenoma and small,well differentiated carcinoid[microcarcinoid(MC)]at its *** incidence of CIAM is 3.8%in surgically resected colorectal *** its pathogenesis is unknown,studies support the role of Wnt/β-catenin pathway in the tumorigenesis of *** have been primarily reported in the colon wherein they present as polyps with well-defined margins,similar to conventional adenomatous *** is usually found in adenomatous polyps with high-risk features such as large size,villous architecture,or high grade ***,the MC component is often multifocal and spans 3.9 to 5.8 millimeters in *** is usually confined within the mucosa but occasional CIAM cases with MC extending to the submucosa have been *** of CIAM demonstrates bland cytology and inconspicuous proliferative *** lesional cells are positive for synaptophysin and 60%to 100%of cases show nuclearβ-catenin *** poses a diagnostic challenge with its morphologic and immunohistochemical resemblance to both benign and malignant lesions,including squamous morules/metaplasia,adenocarcinoma,squamous cell carcinoma,sporadic neuroendocrine tumor and goblet cell *** is an indolent lesion with a favorable *** removal by polypectomy is considered *** and recognition of this rare entity will help arrive at correct diagnosis and improve patient ***,CIAM is not recognized as a subtype of mixed neuroendocrine-nonneuroendocrine neoplasm by WHO.

关键词： composite Adenoma Microcarcinoid composite intestinal adenomamicrocarcinoid Wnt/β-catenin Mixed neuroendocrine-non-neuroendocrine neoplasm

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